Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Sarah Lever"'
Autor:
Roine I. Olsson, Rikard Pehrson, Rongfeng Chen, Jesper Malmberg, Anna Malmberg, Nafizal Hossain, Hanna Grindebacke, Mia Collins, Matti Lepistö, Yao Xiong, Nina Krutrök, Antonio Llinas, Thomas Hansson, Eva L. Hansson, Elisabeth Bäck, Anna Aagaard, Jane McPheat, Linda Thunberg, Sarah Lever, Agnes Leffler, Yafeng Xue, Stefan von Berg, Petter Svanberg, Frank Narjes, Marie Ramnegård, Glyn Hughes, Johan Jirholt
Publikováno v:
Journal of medicinal chemistry. 64(18)
Inverse agonists of the nuclear receptor RORC2 have been widely pursued as a potential treatment for a variety of autoimmune diseases. We have discovered a novel series of isoindoline-based inverse agonists of the nuclear receptor RORC2, derived from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5abd65b9c67744ef1cfe77ef55392ba
https://pubmed.ncbi.nlm.nih.gov/34464130
https://pubmed.ncbi.nlm.nih.gov/34464130
Autor:
Christian Tyrchan, Anna-Pia Palmgren, Hui-Fang Amy Chang, Yunhua Chen, Victoria Ullah, Karin Björhall, Annika Westin Eriksson, Rebecca Fransson, Mickael Mogemark, Tiiu Wennberg, Shuchun Zhao, Bold Peter, Linda Fredlund, Matthew Thomas, Eva Lamm Bergström, Nils Pemberton, Ulf Börjesson, Reed W. Smith, Mikael Brűlls, Johan Carlsson, Britt-Marie Fihn, Linda Öster, Mio Rodrigo Blomqvist, Hongbin Ge, Antonios Nikitidis, Wenzhen Yang, Anders Eriksson, Haijuan Huang, Sarah Lever, Perry Matthew, Kostas Karabelas, Helena Lindmark, Jens Petersen
Publikováno v:
Journal of medicinal chemistry. 64(12)
Starting from our previously described PI3Kγ inhibitors, we describe the exploration of structure-activity relationships that led to the discovery of highly potent dual PI3Kγδ inhibitors. We explored changes in two positions of the molecules, incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f1afe7cc480e1edf37ab207774eb9ff
https://pubmed.ncbi.nlm.nih.gov/34080862
https://pubmed.ncbi.nlm.nih.gov/34080862
Autor:
Emma Evertsson, Mickael Mogemark, Katerina Pardali, Anette Welinder, Ulf Hedström, Sarah Lever, Magnus Munck af Rosenschöld, Pia Berntsson, Andrew M. Davis, Arjan Snijder, Ulf Andersson, Johan Karlsson, Johanna Vinblad, Bold Peter, Monica Norberg, Hans Lönn, Helena Käck, Jianming Liu
Publikováno v:
ChemMedChem. 14:1701-1709
The mitogen-activated protein kinase p38α pathway has been an attractive target for the treatment of inflammatory conditions such as rheumatoid arthritis. While a number of p38α inhibitors have been taken to the clinic, they have been limited by th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f39c0296215a83fa0c9ad2994f9fa1
https://doi.org/10.1002/cmdc.201900303
https://doi.org/10.1002/cmdc.201900303
Autor:
Nils Pemberton, Cristina Gardelli, Jens Petersen, Neil S. Holden, Helena Lindmark, Pavol Zlatoidsky, Sandra Rodrigo Blomqvist, Annika Westin Eriksson, Rhona J. Cox, Linda Öster, Christian Tyrchan, Susanne Arlbrandt, Sarah Lever, Perry Matthew, Bold Peter, Mickael Mogemark, Matthew F. Thomas, A. Monica Norberg, Kostas Karabelas, Johan Karlsson, Xueshan Li
Publikováno v:
'Journal of Medicinal Chemistry ', vol: 61, pages: 5435-5441 (2018)
In this paper, we describe the discovery and optimization of a new chemotype of isoform selective PI3Kγ inhibitors. Starting from an HTS hit, potency and physicochemical properties could be improved to give compounds such as 15, which is a potent an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::522cd582a4e8dd33b4cac2f260c043ff
https://pubmed.ncbi.nlm.nih.gov/29852070
https://pubmed.ncbi.nlm.nih.gov/29852070
Autor:
Richard J. Lewis, Andrew David Morley, Mark C. Wenlock, Bryan Roberts, Malbinder Fagura, Cathy MacDonald, Richard J. Weaver, Timothy Phillips, Sarah Lever, Sarah King, John Unitt, Andrew Cook
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6456-6460
A series of pyrazole inhibitors of the human FPR1 receptor have been identified from high throughput screening. The compounds demonstrate potent inhibition in human neutrophils and attractive physicochemical and in vitro DMPK profiles to be of furthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2cef861bc0abe62efe9a76db820896b
https://doi.org/10.1016/j.bmcl.2011.08.085
https://doi.org/10.1016/j.bmcl.2011.08.085
Publikováno v:
Perspectives on Augmentative and Alternative Communication. 19:32-40
Increasingly, parents of students with complex communication needs have high expectations for life after school. To respond to these high expectations, professionals must ensure that, among other skills, these students have three key supports: (a) ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f15f53afd168b6c4cb8fc5983ecfa3d9
https://doi.org/10.1044/aac19.2.32
https://doi.org/10.1044/aac19.2.32