Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Sarah Legraie"'
Autor:
Víctor Faundes, Martin D. Jennings, Siobhan Crilly, Sarah Legraie, Sarah E. Withers, Sara Cuvertino, Sally J. Davies, Andrew G. L. Douglas, Andrew E. Fry, Victoria Harrison, Jeanne Amiel, Daphné Lehalle, William G. Newman, Patricia Newkirk, Judith Ranells, Miranda Splitt, Laura A. Cross, Carol J. Saunders, Bonnie R. Sullivan, Jorge L. Granadillo, Christopher T. Gordon, Paul R. Kasher, Graham D. Pavitt, Siddharth Banka
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
eIF5A is critical for protein synthesis but has not yet been associated with congenital human disease. Here, the authors show that EIF5A variants cause a Mendelian disorder via reduced eIF5A-ribosome interactions and this phenotype is partially corre
Externí odkaz:
https://doaj.org/article/e484f6bf742d4dfaa468f76258820800
Autor:
Siddharth Banka, Sarah E. Withers, Siobhan Crilly, Daphné Lehalle, Andrew G. L. Douglas, Jorge L. Granadillo, Martin D. Jennings, Sara Cuvertino, William G. Newman, Miranda Splitt, Graham D. Pavitt, Carol J Saunders, Judith D. Ranells, Jeanne Amiel, Sally J. Davies, Sarah Legraie, Patricia Newkirk, Paul R. Kasher, Andrew E. Fry, Víctor Faundes, Laura A Cross, Victoria Harrison, Christopher T. Gordon, Bonnie Sullivan
Publikováno v:
Faundes, V, Jennings, M D, Crilly, S, Legraie, S, Withers, S E, Cuvertino, S, Davies, S J, Douglas, A G L, Fry, A E, Harrison, V, Amiel, J, Lehalle, D, Newman, W G, Newkirk, P, Ranells, J, Splitt, M, Cross, L A, Saunders, C J, Sullivan, B R, Granadillo, J L, Gordon, C T, Kasher, P R, Pavitt, G D & Banka, S 2021, ' Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine ', Nature Communications, vol. 12, no. 1, 833 . https://doi.org/10.1038/s41467-021-21053-2
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Cell Stress
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Cell Stress
The structure of proline prevents it from adopting an optimal position for rapid protein synthesis. Poly-proline-tract (PPT) associated ribosomal stalling is resolved by highly conserved eIF5A, the only protein to contain the amino acid hypusine. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbfd72bfccd4648e9762fd4874387da0
https://www.research.manchester.ac.uk/portal/en/publications/impaired-eif5a-function-causes-a-mendelian-disorder-that-is-partially-rescued-in-model-systems-by-spermidine(d9e95576-9e14-4ca9-8720-4d502339c8cd).html
https://www.research.manchester.ac.uk/portal/en/publications/impaired-eif5a-function-causes-a-mendelian-disorder-that-is-partially-rescued-in-model-systems-by-spermidine(d9e95576-9e14-4ca9-8720-4d502339c8cd).html
