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pro vyhledávání: '"Sarah Lackie"'
Autor:
Peter William Rodney Caulkett, Scott Boyd, Clifford David Jones, Gordon S. Currie, Sarah Lackie, Emma Grange, Craig Johnstone, Barry R. Hayter, Harold Gaskin, Christopher D. Davies, Darren Mckerrecher, Rod B. Hargreaves, Mark L. Fenwick, Roger James, Rayner John Wall, Keith M. Johnson, Joanne V. Allen, Rolf Peter Walker, Suzanne S. Bowker
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:2103-2106
The identification, synthesis and SAR of a novel series of glucokinase activators is described. The interplay between lipophilicity, potency and physical properties is discussed, and compound 22 highlighted as having a suitable balance. In vivo pharm