Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Sarah L. Scarth"'
Autor:
Suet-Mien Tan, S. K. A. Law, L. A. Boxer, Sarah L. Scarth, Dirk Roos, D. L. Simmons, Christopher D. Buckley, S. M. Nolan, Jacqueline Shaw, Nigel Klein, Aymen Al-Shamkhani, Irene Roberts, A. W. Dodds
Publikováno v:
Clinical and Experimental Immunology. 126:311-318
SummaryLeucocyte adhesion deficiency (LAD) is a hereditary disorder caused by mutations in the CD18 (β2 integrin) gene. Four missense mutations have been identified in three patients. CD18(A270V) supports, at a diminished level, CD11b/CD18 (Mac-1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d114b863c26909994ba529b3ecd3afc1
https://doi.org/10.1046/j.1365-2249.2001.01661.x
https://doi.org/10.1046/j.1365-2249.2001.01661.x
Publikováno v:
FEBS Letters. 486:89-92
Of the 56 cysteines in the extracellular domain of the CD18 antigen (beta2 integrin subunit), corresponding ones are not found in 12 positions in the beta4, beta7, or beta8 integrin subunits. These 12 cysteines were mutated to alanines, either singly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b4908f0c4f00547730d4b73542050d7
https://doi.org/10.1016/s0014-5793(00)02247-x
https://doi.org/10.1016/s0014-5793(00)02247-x
Autor:
S. K. Alex Law, Nigel Klein, Mairi P. Stewart, Rebecca Newton, Sarah L. Scarth, Nancy Hogg, Jacqueline Shaw
Publikováno v:
The Journal of clinical investigation. 103(1)
In the leukocyte adhesion deficiency (LAD)-1 syndrome, there is diminished expression of beta2(CD18) integrins. This is caused by lesions in the beta2-subunit gene and gives rise to recurrent bacterial infections, impaired pus formation, and poor wou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eee842bda1251e43ebb646c6b9117c92
https://pubmed.ncbi.nlm.nih.gov/9884339
https://pubmed.ncbi.nlm.nih.gov/9884339
Autor:
S. K. Alex Law, Sarah L. Scarth, Robert H. Hyland, Christopher D. Buckley, Jacqueline Shaw, David Simmons, Wendy A. Douglass, Aymen Al-Shamkhani
Publikováno v:
FEBS Letters. (3):414-418
The cysteine-rich region (CRR) of the beta2 integrin subunit was replaced by that of beta1 to give the chimera beta2NV1. Beta2NV1 can combine with alphaL to form a variant leukocyte-function-associated antigen (LFA)-1 on COS cell surface, suggesting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd263ce3ea7ae20d2e7ba6f67d13c827