Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Sarah L. Rea"'
Autor:
Melanie A. Sultana, Carmel Cluning, Wai-Sin Kwong, Nicole Polain, Nathan J. Pavlos, Thomas Ratajczak, John P. Walsh, Jiake Xu, Sarah L. Rea
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
The LIM-domain containing protein Ajuba and the scaffold protein SQSTM1/p62 regulate signalling of NF-κB, a transcription factor involved in osteoclast differentiation and survival. The ubiquitin-associated domain of SQSTM1/p62 is frequently mutated
Externí odkaz:
https://doaj.org/article/ce95db131b1e48aea8e11c033670fb12
Autor:
Nicole Polain, Wai Sin Kwong, Thomas Ratajczak, Sarah L. Rea, John P. Walsh, Carmel Cluning, Melanie A. Sultana, Jiake Xu, Nathan J. Pavlos
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 11, p e0259556 (2021)
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE, Vol 16, Iss 11, p e0259556 (2021)
PLoS ONE, Vol 16, Iss 11 (2021)
The LIM-domain containing protein Ajuba and the scaffold protein SQSTM1/p62 regulate signalling of NF-κB, a transcription factor involved in osteoclast differentiation and survival. The ubiquitin-associated domain of SQSTM1/p62 is frequently mutated
Autor:
Andrew J. Lee, Justin J. Yerbury, C. Cluning, Sarah L. Rea, P.A. Akkari, Jennilee M. Davidson, R. Mejzini, A. D. Foster, Flora Cheng, N. Polain, Loren L. Flynn, Natalie E. Farrawell, Robert Layfield
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) that exist on a spectrum of neurodegenerative disease. A hallmark of pathology is cytoplasmic TDP-43 aggregates within neurons, observed in 97% of ALS cases and ~ 50% of
Publikováno v:
Molecular and Cellular Neuroscience. 98:32-45
Elevated oxidative stress has been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD). In response to oxidative stress, the Nrf2 transcription factor activates protective antioxidant gen
Autor:
Prashant Bharadwaj, Ralph N. Martins, Dona P.W. Jayatunga, Yasaswi Shrestha, Sarah L. Rea, Sharmeelavathi Krishnan
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 6739, p 6739 (2020)
International Journal of Molecular Sciences, Vol 21, Iss 6739, p 6739 (2020)
Neurodegenerative diseases result in a range of conditions depending on the type of proteinopathy, genes affected or the location of the degeneration in the brain. Proteinopathies such as senile plaques and neurofibrillary tangles in the brain are pr
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4705, p 4705 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are neurodegenerative disorders that exist on a disease spectrum due to pathological, clinical and genetic overlap. In up to 97% of ALS cases and ~50% of FTLD cases, the
Publikováno v:
Molecular and Cellular Neurosciences
The transcription factor Nrf2 and its repressor protein Keap1 play key roles in the regulation of antioxidant stress responses and both Keap1-Nrf2 signalling and oxidative stress have been implicated in the pathogenesis of the ALS-FTLD spectrum of ne
Publikováno v:
Bone Reports, Vol 10, Iss, Pp-(2019)
Bone Reports
Bone Reports
Paget's disease of bone (PDB) has a strong genetic component. Variants in SQSTM1 are found in up to 40% of patients with a family history of the disease, where a pattern of autosomal dominance with incomplete penetrance is apparent. By contrast, SQST
Publikováno v:
Molecular and Cellular Neuroscience. 108:103539
Mutations affecting SQSTM1 coding for p62 and TANK-Binding Kinase 1 (TBK1) have been implicated in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). TBK1 is a serine-threonine kinase that regulates p62's activity as an
Autor:
Jennifer Tickner, Haotian Feng, Taksum Cheng, Thomas Ratajczak, Nathan J. Pavlos, Huazi Xu, Sipin Zhu, John P. Walsh, Jiake Xu, Sarah L. Rea
Publikováno v:
Journal of Cellular Biochemistry. 117:1464-1470
Vacuolar proton pump H(+)-adenosine triphosphatases (V-ATPases) play an important role in osteoclast function. Further understanding of the cellular and molecular mechanisms of V-ATPase inhibition is vital for the development of anti-resorptive drugs