Data from Evaluation of CDK12 Protein Expression as a Potential Novel Biomarker for DNA Damage Response–Targeted Therapies in Breast Cancer

Autor: Rachael Natrajan, Andrew R. Green, Yinyin Yuan, Christopher J. Lord, Ian O. Ellis, Emad A. Rhaka, Srinivasan Madhusudan, Stephen Y.T. Chan, Tarek M.A. Abdel-Fatah, Paul M. Moseley, Andrew Tutt, Anita Grigoriadis, Hasan Mirza, James Campbell, Divya Kriplani, Syed Haider, Frances Daley, Sarah L. Maguire, Patty T. Wai, Kalnisha Naidoo

Disruption of Cyclin-Dependent Kinase 12 (CDK12) is known to lead to defects in DNA repair and sensitivity to platinum salts and PARP1/2 inhibitors. However, CDK12 has also been proposed as an oncogene in breast cancer. We therefore aimed to assess t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228fc5e822851794fd6455a376e7856b
https://doi.org/10.1158/1535-7163.c.6539677.v1

Data from 3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer

Autor: Rachael Natrajan, Andrew N. Tutt, Syed Haider, Jyoti S. Choudhary, Fredrik Wallberg, Frances Daley, Paul Huang, Lukas Krasny, Simon McDade, Gerard Quinn, Sophie Postel-Vinay, Farzana Noor, Maggie C.U. Cheang, Erle M. Holgersen, Lesley-Ann Martin, Sunil Pancholi, Ioannis Roxanis, Patrycja Gazinska, Kalnisha Naidoo, Natasa Medic Milijic, Snezana Susnjar, Daniela Kolarevic, Naomi Guppy, Eleanor Knight, Daniela Novo, Rebecca Marlow, Richard Buus, Gillian Farnie, Keith Brennan, Giulia Falgari, Amy Gibson, Lu Yu, Divya Kriplani, Eamonn Morrison, Holly E. Barker, Sarah L. Maguire, Patty T. Wai, Hannah Cottom, Gareth Muirhead, Ioanna Mavrommati, Philip Bland, Barrie Peck

Triple-negative breast cancers (TNBC) are resistant to standard-of-care chemotherapy and lack known targetable driver gene alterations. Identification of novel drivers could aid the discovery of new treatment strategies for this hard-to-treat patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f47c62b476b5b1eb748b5362d5aeca
https://doi.org/10.1158/0008-5472.c.6512466.v1

Supplementary Methods from 3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer

Autor: Rachael Natrajan, Andrew N. Tutt, Syed Haider, Jyoti S. Choudhary, Fredrik Wallberg, Frances Daley, Paul Huang, Lukas Krasny, Simon McDade, Gerard Quinn, Sophie Postel-Vinay, Farzana Noor, Maggie C.U. Cheang, Erle M. Holgersen, Lesley-Ann Martin, Sunil Pancholi, Ioannis Roxanis, Patrycja Gazinska, Kalnisha Naidoo, Natasa Medic Milijic, Snezana Susnjar, Daniela Kolarevic, Naomi Guppy, Eleanor Knight, Daniela Novo, Rebecca Marlow, Richard Buus, Gillian Farnie, Keith Brennan, Giulia Falgari, Amy Gibson, Lu Yu, Divya Kriplani, Eamonn Morrison, Holly E. Barker, Sarah L. Maguire, Patty T. Wai, Hannah Cottom, Gareth Muirhead, Ioanna Mavrommati, Philip Bland, Barrie Peck

Supplementary Materials and Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03c4effcc5998d9f682e738dbf181bdc
https://doi.org/10.1158/0008-5472.22426845

Exploring the clinical and genetic associations of adult weight trajectories using electronic health records in a racially diverse biobank: a phenome-wide and polygenic risk study

Autor: Jiayi Xu, Jessica S Johnson, Rebecca Signer, Andreas Birgegård, Jennifer Jordan, Martin A Kennedy, Mikael Landén, Sarah L Maguire, Nicholas G Martin, Preben Bo Mortensen, Liselotte V Petersen, Laura M Thornton, Cynthia M Bulik, Laura M Huckins

Publikováno v: Xu, J, Johnson, J S, Signer, R, Eating Disorders Working Group of the Psychiatric Genomics Consortium, Birgegård, A, Jordan, J, Kennedy, M A, Landén, M, Maguire, S L, Martin, N G, Mortensen, P B, Petersen, L V, Thornton, L M, Bulik, C M & Huckins, L M 2022, ' Exploring the clinical and genetic associations of adult weight trajectories using electronic health records in a racially diverse biobank : a phenome-wide and polygenic risk study ', The Lancet. Digital health, vol. 4, no. 8, pp. e604-e614 . https://doi.org/10.1016/S2589-7500(22)00099-1

BACKGROUND: Weight trajectories might reflect individual health status. In this study, we aimed to examine the clinical and genetic associations of adult weight trajectories using electronic health records (EHRs) in the BioMe Biobank.METHODS: We cons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1cd78101b8f8fc552c994adce836023
https://pubmed.ncbi.nlm.nih.gov/35780037

Conserved and divergent roles of Bcr1 and CFEM proteins in Candida parapsilosis and Candida albicans.

Autor: Chen Ding, Genevieve M Vidanes, Sarah L Maguire, Alessandro Guida, John M Synnott, David R Andes, Geraldine Butler

Publikováno v: PLoS ONE, Vol 6, Iss 12, p e28151 (2011)

Candida parapsilosis is a pathogenic fungus that is major cause of hospital-acquired infection, predominantly due to growth as biofilms on indwelling medical devices. It is related to Candida albicans, which remains the most common cause of candidias

Externí odkaz: https://doaj.org/article/3f2e593a1db246a281b806796846c953