Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Sarah L. Hunt"'
Autor:
Claudine Tardy, Kathryn Newton, Marcos Malumbres, Antonio Cerqueira, Javier F. Cáceres, David Santamaría, Cédric Barrière, Mariano Barbacid, Pierre Dubus, Sarah L. Hunt
Publikováno v:
Nature. 448:811-815
Unicellular organisms such as yeasts require a single cyclin-dependent kinase, Cdk1, to drive cell division. In contrast, mammalian cells are thought to require the sequential activation of at least four different cyclin-dependent kinases, Cdk2, Cdk3
Autor:
Sagrario Ortega, Albert F. Parlow, Pierre Dubus, Rocio Sotillo, Mariano Barbacid, Fanny Nehmé-Pelluard, Marcos Malumbres, Mark A. Magnuson, Javier Martín, Sarah L. Hunt
Publikováno v:
Oncogene. 22:5261-5269
Lack of Cdk4 expression in mice leads to insulin-deficient diabetes and female infertility owing to a reduced number of pancreatic beta cells and prolactin-producing pituitary lactotrophs, respectively. Cdk4 null mice display also reduced body and or
Publikováno v:
Pediatric Neurology. 23:160-163
The effectiveness of lamotrigine as a monotherapeutic agent for a variety of pediatric epilepsies was reviewed retrospectively. Children were categorized as having focal vs generalized epilepsy and according to whether they were antiepileptic drug na
Publikováno v:
Genes & Development. 13:437-448
Initiation of translation of the animal picornavirus RNAs occurs via a mechanism of direct ribosome entry, which requires a segment of the 5' UTR of the RNA, known as the internal ribosome entry site (IRES). In addition, translation of the enteroviru
Publikováno v:
Future Oncology. 11:35-36
ABSTRACT Pulmonary metastasectomy has become an established mode of therapy in the management of certain patients with metastatic colorectal cancer. All patients undergoing pulmonary resection for metastatic colorectal cancer between March 2008 and F
Autor:
Todd F. Barron, Sarah L. Hunt
Publikováno v:
Clinical Pediatrics. 36:513-521
Since 1994, three new antiepileptic drugs, felbamate, lamotrigene, and gabapentin, have been released for the treatment of epilepsy. The present paper provides an overview of these three drugs and reviews their potential uses in pediatric epilepsy ev
Publikováno v:
Virology. 197:801-807
Since internal initiation of translation of cardiovirus RNAs requires the approximately 450-nt segment of the viral genome immediately upstream of the authentic initiation codon for viral polyprotein synthesis, the question arises as to whether the i
Publikováno v:
The Journal of general virology. 88(Pt 11)
Internal initiation of translation from the human rhinovirus-2 (HRV-2) internal ribosome entry site (IRES) is dependent upon host cell trans-acting factors. The multiple cold shock domain protein Unr and the polypyrimidine tract-binding protein have
Autor:
Marcos, Malumbres, Sarah L, Hunt, Rocío, Sotillo, Javier, Martín, Jun, Odajima, Alberto, Martín, Pierre, Dubus, Sagrario, Ortega, Mariano, Barbacid
Publikováno v:
Advances in experimental medicine and biology. 532
Cell cycle progression requires the co-ordinated activation of several kinases, some of which are activated upon the binding of a cyclin subunit. At least four of these so-called cyclin-dependent kinases, namely Cdk4, Cdk6, Cdk2 and Cdk1, have specif
Autor:
Marcos Malumbres, Pierre Dubus, Sagrario Ortega, Jun Odajima, Javier Martín, Sarah L. Hunt, Alberto Martín, Rocio Sotillo, Mariano Barbacid
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9780306477621
ResearcherID
ResearcherID
Cell cycle progression requires the co-ordinated activation of several kinases, some of which are activated upon the binding of a cyclin subunit. At least four of these so-called cyclin-dependent kinases, namely Cdk4, Cdk6, Cdk2 and Cdk1, have specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf714e0fd177ffb8c72281057754741
https://doi.org/10.1007/978-1-4615-0081-0_1
https://doi.org/10.1007/978-1-4615-0081-0_1