Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sarah L. Griner"'
Autor:
Einav Tayeb-Fligelman, Jeannette T. Bowler, Christen E. Tai, Michael R. Sawaya, Yi Xiao Jiang, Gustavo Garcia, Sarah L. Griner, Xinyi Cheng, Lukasz Salwinski, Liisa Lutter, Paul M. Seidler, Jiahui Lu, Gregory M. Rosenberg, Ke Hou, Romany Abskharon, Hope Pan, Chih-Te Zee, David R. Boyer, Yan Li, Daniel H. Anderson, Kevin A. Murray, Genesis Falcon, Duilio Cascio, Lorena Saelices, Robert Damoiseaux, Vaithilingaraja Arumugaswami, Feng Guo, David S. Eisenberg
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The self-assembly of the Nucleocapsid protein (NCAP) of SARS-CoV-2 is crucial for its function. Computational analysis of the amino acid sequence of NCAP reveals low-complexity domains (LCDs) akin to LCDs in other proteins known to self-asse
Externí odkaz:
https://doaj.org/article/afcfb5ca25ff4981a1a88a2f530c23e4
Autor:
Sarah L Griner, Paul Seidler, Jeannette Bowler, Kevin A Murray, Tianxiao Peter Yang, Shruti Sahay, Michael R Sawaya, Duilio Cascio, Jose A Rodriguez, Stephan Philipp, Justyna Sosna, Charles G Glabe, Tamir Gonen, David S Eisenberg
Publikováno v:
eLife, Vol 8 (2019)
Alzheimer’s disease (AD) pathology is characterized by plaques of amyloid beta (Aβ) and neurofibrillary tangles of tau. Aβ aggregation is thought to occur at early stages of the disease, and ultimately gives way to the formation of tau tangles wh
Externí odkaz:
https://doaj.org/article/b2be6583aeff446ab32b99c277fc5857
Autor:
Kevin A. Murray, Carolyn J. Hu, Sarah L. Griner, Hope Pan, Jeannette T. Bowler, Romany Abskharon, Gregory M. Rosenberg, Xinyi Cheng, Paul M. Seidler, David S. Eisenberg
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 34
Neurodegenerative diseases are characterized by the pathologic accumulation of aggregated proteins. Known as amyloid, these fibrillar aggregates include proteins such as tau and amyloid-β (Aβ) in Alzheimer’s disease (AD) and alpha-synuclein (αSy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e65fcad4018162bc9dd405fdedae227
https://doi.org/10.1073/pnas.2206240119
https://doi.org/10.1073/pnas.2206240119
Autor:
Janet Finer-Moore, Oliv Eidam, Sarah L. Griner, Joseph D. O'Connell, Anna Tochowicz, Sean Mark Dalziel, Robert M. Stroud
Publikováno v:
Journal of Medicinal Chemistry. 56:5446-5455
N-[4-[2-Propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-d-glutamic acid 1 (BGC 945, now known as ONX 0801), is a small molecule thymidylate synthase (TS) inhibitor discovered at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4af04022691ba1464976b2feb6c4cc18
https://doi.org/10.1021/jm400490e
https://doi.org/10.1021/jm400490e
Autor:
Moshe Kotler, Meytal Galilee, Elena Britan-Rosich, Akram Alian, Don C. Lamb, Robert M. Stroud, Anthony A. Kossiakoff, Serdar Uysal, Viola Baumgärtel, Sarah L. Griner, Ailie Marx
HIV-1 integrase (IN) catalyzes viral DNA integration into the host genome and facilitates multifunctional steps including virus particle maturation. Competency of IN to form multimeric assemblies is functionally critical, presenting an approach for a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f337693bbf0f824149a69743288c5acf
https://openaccess.bezmialem.edu.tr/handle/20.500.12645/13453
https://openaccess.bezmialem.edu.tr/handle/20.500.12645/13453
Autor:
Romas Geleziunas, Gabriel Birkus, Andrew D. Leavitt, Robert M. Stroud, Sarah L. Griner, Akram Alian, Gregg S. Jones, Vicki Chiang, Manuel Tsiang
HIV-1 integration into the host cell genome is a multistep process catalyzed by the virally-encoded integrase (IN) protein. In view of the difficulty of obtaining a stable DNA-bound IN at high concentration as required for structure determination, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7258be5626bff26a91ad8419ebb1fc
https://europepmc.org/articles/PMC2688900/
https://europepmc.org/articles/PMC2688900/
Publikováno v:
Journal of molecular biology. 388(4)
Escherichia coli pseudouridine synthase RluF is dedicated to modifying U2604 in a stem–loop of 23S RNA, while a homologue, RluB, modifies the adjacent base, U2605. Both uridines are in the same RNA stem, separated by ∼ 4 A. The 3.0 A X-ray crysta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d125d4d8592d8a44ad1e008cdd1783f
https://pubmed.ncbi.nlm.nih.gov/19298824
https://pubmed.ncbi.nlm.nih.gov/19298824
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 105(19)
TrmA catalyzes S -adenosylmethionine (AdoMet)-dependent methylation of U54 in most tRNAs. We solved the structure of the Escherichia coli 5-methyluridine (m 5 U) 54 tRNA methyltransferase (MTase) TrmA in a covalent complex with a 19-nt T arm analog t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c765fcd351b9b657ce380be1b7adf62
https://pubmed.ncbi.nlm.nih.gov/18451029
https://pubmed.ncbi.nlm.nih.gov/18451029
Autor:
Agustin Avila-Sakar, Sarah L. Griner, Pavel Strop, Robert M. Stroud, Shenping Wu, Akram Alian, Charles S. Craik, Yadong Yu, Javier Chaparro-Riggers, Maofu Liao, Claudia M. Mergel, Narinobu Juge, Robert Tampé, Yifan Cheng, Xueming Li, JungMin Kim, Andrea Rossi, David S. Booth, Robert H. Edwards, Charles H. Greenberg
Publikováno v:
Structure. (4):582-592
SummaryIn spite of its recent achievements, the technique of single particle electron cryomicroscopy (cryoEM) has not been widely used to study proteins smaller than 100 kDa, although it is a highly desirable application of this technique. One fundam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33bf687efda9006ce0bcc58a2d8db1ac