Výsledky vyhledávání - "Sarah L. Cockerill"

Engagement of the EP2 prostanoid receptor closes the K+ channel KCa3.1 in human lung mast cells and attenuates their migration

Autor: Peter Bradding, Sarah L. Cockerill, S. Mark Duffy, Christopher E. Brightling, Glenn Cruse

Publikováno v: European Journal of Immunology

Human lung mast cells (HLMC) express the Ca(2+)-activated K(+) channel K(Ca)3.1, which plays a crucial role in their migration to a variety of diverse chemotactic stimuli. K(Ca)3.1 activation is attenuated by the beta(2)-adrenoceptor and the adenosin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ca305e203b6f1e4540bd6874125771
https://doi.org/10.1002/eji.200738106

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Modulation of hERG potassium currents in HEK-293 cells by protein kinase C. Evidence for direct phosphorylation of pore forming subunits

Autor: N. B. Standen, John S. Mitcheson, Sarah L. Cockerill, Gary B. Willars, Ignacio Torrecilla, Andrew B. Tobin

Publikováno v: The Journal of Physiology. 581:479-493

The human ether-a-go-go related gene (hERG) potassium channel is expressed in a variety of tissues including the heart, neurons and some cancer cells. hERG channels are modulated by several intracellular signalling pathways and these provide importan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf50cd1482e6c949fb4e5577a031855f
https://doi.org/10.1113/jphysiol.2006.123414

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Direct block of human ether-a-go-go-related gene potassium channels by caffeine

Autor: John S. Mitcheson, Sarah L. Cockerill

Publikováno v: The Journal of pharmacology and experimental therapeutics. 316(2)

The human ether-a-go-go-related gene (hERG) potassium channel is expressed in a variety of cell types, including neurons, tumor cells, and cardiac myocytes. In the heart, it is important for repolarization of the cardiac action potential. Attenuation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e3b8358785d504012b514158e07e3fb
https://pubmed.ncbi.nlm.nih.gov/16227470

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IgE alone promotes human lung mast cell survival through the autocrine production of IL-6

Autor: Peter Bradding, Sarah L. Cockerill, Glenn Cruse

Publikováno v: BMC Immunology
BMC Immunology, Vol 9, Iss 1, p 2 (2008)

Background Mast cells play a key role in asthma and recent evidence indicates that their ongoing activation in this disease is mediated, in part, via IgE in the absence of antigen. In this study we have examined whether IgE alone enhances human lung

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad23072eca8b5ade95a05d1568fd2581
https://doi.org/10.1186/1471-2172-9-2

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