Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Sarah L. Bray"'
Autor:
Shahid Abbas, Nicole Soranzo, Nabi Shah, Muhammed Murtaza, Nadeem Hayat Mallick, Jawaid Hassan Niazi, Muhammad Salman Daood, Sarah L. Bray, Kishore Kumar, Stephen Kaptoge, Tanja B. Grammer, Ralph McGinnis, Adam S. Butterworth, Muhammad Azhar, Marcus E. Kleber, Syed Saadat Ali, Faisal Shahid, Willem H. Ouwehand, Moazzam Zaidi, Muhammad Ishaq, Simon C. Potter, Frank Dudbridge, Mustafa Hussain, Danish Saleheen, Shahzad Majeed Bhatti, Gurdeep S. Sagoo, Hubert Scharnagl, Kerstin Koch, Zia Yaqoob, Wilfried Renner, Simon G. Thompson, Abdus Samad, Aftab Alam Gul, Abdul Hakeem, Michael M. Hoffmann, Suzanna Bumpstead, Maria Samuel, Asim Saleem, Asif Rasheed, Usman Ahmad, Nasir Sheikh, Alexander M. W. Cargill Thompson, Myriam Alexander, Emanuele Di Angelantonio, Fazal-ur Rehman, Ali Raza Gardezi, Reeta Gobin, Nadeem Sarwar, Rashid Jooma, J. Stephens, Assadullah Kundi, Philippe M. Frossard, Khan Shah Zaman, Winfried März, Kishwar Kumar, Michael Inouye, Shajjia Razi Haider, Sarah E. Hunt, Nadeem Qamar, Fahim Muhammad, Panos Deloukas, Liaquat Ali Cheema, Anthony Attwood, Azhar Faruqui, Junaid Zafar, Syed Zahed Rasheed, Abdul Ghaffar, Bernhard O. Boehm, Rhian Gwilliam, Bernhard R. Winkelmann, John Danesh, Philip Haycock, Nazir Ahmed Memon
Publikováno v:
Circulation: Cardiovascular Genetics. 3:348-357
Background— Evidence is sparse about the genetic determinants of major lipids in Pakistanis. Methods and Results— Variants (n=45 000) across 2000 genes were assessed in 3200 Pakistanis and compared with 2450 Germans using the same gene array and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a91bd21777dd78b72df83a497c204c1a
https://doi.org/10.1161/circgenetics.109.906180
https://doi.org/10.1161/circgenetics.109.906180
Publikováno v:
Human Heredity. 70:167-176
Genome-wide association studies (GWASs) aim to genotype enough single nucleotide polymorphisms (SNPs) to effectively capture common genetic variants across the genome. Even though the number of SNPs genotyped in such studies can exceed a million, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fe11bbca9a5f52bbf87ea68d814c68f
https://doi.org/10.1159/000308456
https://doi.org/10.1159/000308456
Autor:
Willem H. Ouwehand, Nilesh J. Samani, Panos Deloukas, Frank Dudbridge, Jan-Willem N. Akkerman, Sarah L. Bray, Alison J. Coffey, Michael Steward, Marc Hoylaerts, Jonathan Stephens, Catherine M. Rice, Angela Rankin, Alison H. Goodall, Nicholas A. Watkins, Stephen F. Garner, Adam Walker, Philippa Burns, David Bentley, Jane Rogers, Richard W. Farndale, Chris I. Jones, Mark E. Earthrowl, W. Angenent, Kerstin Koch, Bernard de Bono
Publikováno v:
Blood. 114:1405-1416
Platelet response to activation varies widely between individuals but shows interindividual consistency and strong heritability. The genetic basis of this variation has not been properly explored. We therefore systematically measured the effect on fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754778b171d8f70653c2447c3cd566aa
https://doi.org/10.1182/blood-2009-02-202614
https://doi.org/10.1182/blood-2009-02-202614
Autor:
Mieke D. Trip, Hans Deckmyn, Patricia B. Maguire, Nilesh J. Samani, Derek L. Stemple, Arief Gusnanto, Philippa Burns, Frank Dudbridge, Marie N. O'Connor, Cordelia Langford, Nicholas A. Watkins, Desmond J. Fitzgerald, Sarah L. Bray, Bernard de Bono, Alison H. Goodall, Iain C. Macaulay, Diego Ardissino, Willem H. Ouwehand, Kerstin Koch, Stephen F. Garner, Catherine M. Rice, Jaap-Jan Zwaginga, Chris I. Jones, Isabelle I. Salles, Jonathan Stephens
Publikováno v:
Blood, 116(22), 4646-4656. American Society of Hematology
Within the healthy population, there is substantial, heritable, and interindividual variability in the platelet response. We explored whether a proportion of this variability could be accounted for by interindividual variation in gene expression. Thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::910a2476e4c6003f7513b6b6edcce7f3
https://pubmed.ncbi.nlm.nih.gov/20833976
https://pubmed.ncbi.nlm.nih.gov/20833976
Autor:
Jaap-Jan Zwaginga, Chris I. Jones, Derek L. Stemple, Marie N. O'Connor, Ana Cvejic, Hans Deckmyn, Frank Dudbridge, Iain C. Macaulay, Nicholas A. Watkins, Isabelle I. Salles, Alison H. Goodall, Sarah L. Bray, Adam Walker, Bernard de Bono, Michael Steward, Willem H. Ouwehand, Stephen F. Garner
Publikováno v:
Blood
In this study, we demonstrate the suitability of the vertebrate Danio rerio (zebrafish) for functional screening of novel platelet genes in vivo by reverse genetics. Comparative transcript analysis of platelets and their precursor cell, the megakaryo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24bb4bf10b774a8448607b0e292c321a
http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=19109564
http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=19109564
Autor:
Holger Prokisch, Angela Döring, Nilesh J. Samani, Christa Meisinger, Simon C. Potter, Jeanette Erdmann, Wendy N. Erber, Angela Rankin, Nicole Soranzo, Jennifer Jolley, John Bradley, Swee Lay Thein, Stephen F. Garner, Willem H. Ouwehand, Panos Deloukas, Stephan Menzel, Heribert Schunkert, Mario Falchi, Nicholas A. Watkins, Christian Gieger, Augusto Rendon, Philippa Burns, Alison H. Goodall, Jonathan Stephens, Chris I. Jones, Tim D. Spector, Brigitte Kühnel, Sarah L. Bray, Thomas Illig
Publikováno v:
Blood. 113(16)
Mean platelet volume (MPV) and platelet count (PLT) are highly heritable and tightly regulated traits. We performed a genome-wide association study for MPV and identified one SNP, rs342293, as having highly significant and reproducible association wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3683b84e398e77ac94daa737d7beff1
https://pubmed.ncbi.nlm.nih.gov/19221038
https://pubmed.ncbi.nlm.nih.gov/19221038
Autor:
Jonathan Stephens, W. Angenent, Nicholas A. Watkins, Panos Deloukas, Bernard de Bono, Sarah L. Bray, Willem H. Ouwehand, Chris I. Jones, Catherine M. Rice, Alison H. Goodall, Frank Dudbridge, Stephen F. Garner, Philippa Burns, Richard W. Farndale
Publikováno v:
Blood. 112:1844-1844
The extent of platelet response to agonists varies between individuals and is to a large extent genetically controlled. Here we present the results of a systems biology study designed to define the association between sequence variation and platelet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0db6207eaef42f29805658da37f6bad
https://doi.org/10.1182/blood.v112.11.1844.1844
https://doi.org/10.1182/blood.v112.11.1844.1844