Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Sarah L Noton"'
Autor:
Tessa N Cressey, Afzaal M Shareef, Victoria A Kleiner, Sarah L Noton, Patrick O Byrne, Jason S McLellan, Elke Mühlberger, Rachel Fearns
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010451 (2022)
De novo initiation by viral RNA-dependent RNA polymerases often requires a polymerase priming residue, located within a priming loop, to stabilize the initiating NTPs. Polymerase structures from three different non-segmented negative strand RNA virus
Externí odkaz:
https://doaj.org/article/0a13506617e34b1f876b02efa62ecf13
Autor:
Molly R Braun, Sarah L Noton, Emmeline L Blanchard, Afzaal Shareef, Philip J Santangelo, W Evan Johnson, Rachel Fearns
Publikováno v:
PLoS Pathogens, Vol 17, Iss 5, p e1009589 (2021)
Respiratory syncytial virus (RSV) is a major cause of respiratory disease in infants and the elderly. RSV is a non-segmented negative strand RNA virus. The viral M2-1 protein plays a key role in viral transcription, serving as an elongation factor to
Externí odkaz:
https://doaj.org/article/c6569cf61bf349b3955629b22207088c
Autor:
Michael H J Rhodin, Nicole V McAllister, Jonathan Castillo, Sarah L Noton, Rachel Fearns, In Jong Kim, Jianming Yu, Thomas P Blaisdell, Joseph Panarese, Brian C Shook, Yat Sun Or, Bryan Goodwin, Kai Lin
Publikováno v:
PLoS Pathogens, Vol 17, Iss 3, p e1009428 (2021)
EDP-938 is a novel non-fusion replication inhibitor of respiratory syncytial virus (RSV). It is highly active against all RSV-A and B laboratory strains and clinical isolates tested in vitro in various cell lines and assays, with half-maximal effecti
Externí odkaz:
https://doaj.org/article/4812af9d50bd47be8b478ee841cb733f
Autor:
Emmeline L Blanchard, Molly R Braun, Aaron W Lifland, Barbara Ludeke, Sarah L Noton, Daryll Vanover, Chiara Zurla, Rachel Fearns, Philip J Santangelo
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1008987 (2020)
The ribonucleocapsid complex of respiratory syncytial virus (RSV) is responsible for both viral mRNA transcription and viral replication during infection, though little is known about how this dual function is achieved. Here, we report the use of a r
Externí odkaz:
https://doaj.org/article/bd22234259b348fcbf5df7b236decc41
Publikováno v:
PLoS Pathogens, Vol 15, Iss 2, p e1007548 (2019)
Externí odkaz:
https://doaj.org/article/f629503bcadf4084a1e27f7bf2fd5615
Autor:
Molly R Braun, Laure R Deflubé, Sarah L Noton, Michael E Mawhorter, Chadene Z Tremaglio, Rachel Fearns
Publikováno v:
PLoS Pathogens, Vol 13, Iss 12, p e1006803 (2017)
The large polymerase subunit (L) of non-segmented negative strand RNA viruses transcribes viral mRNAs and replicates the viral genome. Studies with VSV have shown that conserved region V (CRV) of the L protein is part of the capping domain. However,
Externí odkaz:
https://doaj.org/article/a01796760bfd4f14b8ef7c9f4a1b1da0
Autor:
Tessa N. Cressey, Afzaal M. Shareef, Victoria A. Kleiner, Sarah L. Noton, Patrick O. Byrne, Jason S. McLellan, Elke Mühlberger, Rachel Fearns
De novo initiation by viral RNA-dependent RNA polymerases often requires a polymerase priming residue, located within a priming loop, to stabilize the initiating NTPs. Polymerase structures from three different non-segmented negative strand RNA virus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa55a115356ff51185fdaa1e2b7fa11
https://doi.org/10.1101/2022.03.18.484858
https://doi.org/10.1101/2022.03.18.484858
Autor:
Sarah L. Noton, Junhua Pan, Simon Lattmann, Tiong Han Yeo, Rachel Fearns, Tessa N. Cressey, Xinlei Qian, Abbas El Sahili, Julien Lescar, Huan Jia, Marian Kalocsay, Barbara Ludeke
Publikováno v:
Nature
Respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) cause severe respiratory diseases in infants and elderly adults1. No vaccine or effective antiviral therapy currently exists to control RSV or HMPV infections. During viral genome rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef44955d71cbfe4f2336a624ef0029c6
https://doi.org/10.1038/s41586-019-1759-1
https://doi.org/10.1038/s41586-019-1759-1
Autor:
Jianming Yu, Jonathan Patrick Castillo, Michael H. J. Rhodin, Shook Brian C, Yat Sun Or, Nicole McAllister, Blaisdell Thomas P, Bryan Goodwin, In Jong Kim, Rachel Fearns, Kai Lin, Joseph D. Panarese, Sarah L. Noton
Publikováno v:
PLoS Pathogens, Vol 17, Iss 3, p e1009428 (2021)
PLoS Pathogens
PLoS Pathogens
EDP-938 is a novel non-fusion replication inhibitor of respiratory syncytial virus (RSV). It is highly active against all RSV-A and B laboratory strains and clinical isolates tested in vitro in various cell lines and assays, with half-maximal effecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0a6592e56b65574881708ca316abf3f
https://doaj.org/article/4812af9d50bd47be8b478ee841cb733f
https://doaj.org/article/4812af9d50bd47be8b478ee841cb733f
Publikováno v:
PLoS Pathogens, Vol 8, Iss 10, p e1002980 (2012)
Respiratory syncytial virus (RSV) is an RNA virus in the Family Paramyxoviridae. Here, the activities performed by the RSV polymerase when it encounters the viral antigenomic promoter were examined. RSV RNA synthesis was reconstituted in vitro using
Externí odkaz:
https://doaj.org/article/f19f1f903efd4d5a8c40fd183725bc5b