Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Sarah L Ellis"'
Autor:
Sharon Tran, Juliani Juliani, Tiffany J. Harris, Marco Evangelista, Julian Ratcliffe, Sarah L. Ellis, David Baloyan, Camilla M. Reehorst, Rebecca Nightingale, Ian Y. Luk, Laura J. Jenkins, Sonia Ghilas, Marina H. Yakou, Chantelle Inguanti, Chad Johnson, Michael Buchert, James C. Lee, Peter De Cruz, Kinga Duszyc, Paul A. Gleeson, Benjamin T. Kile, Lisa A. Mielke, Alpha S. Yap, John M. Mariadason, W. Douglas Fairlie, Erinna F. Lee
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Autophagy-related genes have been closely associated with intestinal homeostasis. BECLIN1 is a component of Class III phosphatidylinositol 3-kinase complexes that orchestrate autophagy initiation and endocytic trafficking. Here we show intes
Externí odkaz:
https://doaj.org/article/fc863b699bb647f5926120d1c9e15000
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52351 (2012)
Heat induces Hsp70.1 (HSPA1) and Hsc70 (HSPA8) to form complex detergent insoluble cytoplasmic and nuclear structures that are distinct from the cytoskeleton and internal cell membranes. These novel structures have not been observed by earlier immuno
Externí odkaz:
https://doaj.org/article/fab2197f28084ae199163cf76363557e
Autor:
Tirta M. Djajawi, Lizzy Pijpers, Akash Srivaths, David Chisanga, Kok Fei Chan, Simon J. Hogg, Liam Neil, Sarahi Mendoza Rivera, Nenad Bartonicek, Sarah L. Ellis, Terry C.C. Lim Kam Sian, Pouya Faridi, Yang Liao, Bhupinder Pal, Andreas Behren, Wei Shi, Stephin J. Vervoort, Ricky W. Johnstone, Conor J. Kearney
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113831- (2024)
Summary: Cancer immunotherapies have demonstrated remarkable success; however, the majority of patients do not respond or develop resistance. Here, we conduct epigenetic gene-targeted CRISPR-Cas9 screens to identify epigenomic factors that limit CD8+
Externí odkaz:
https://doaj.org/article/f34b9312d8234fce939c7254165dac3d
Autor:
Shen Y. Heazlewood, Tanveer Ahmad, Benjamin Cao, Huimin Cao, Melanie Domingues, Xuan Sun, Chad K. Heazlewood, Songhui Li, Brenda Williams, Madeline Fulton, Jacinta F. White, Tom Nebl, Christian M. Nefzger, Jose M. Polo, Benjamin T. Kile, Felix Kraus, Michael T. Ryan, Yu B. Sun, Peter F. M. Choong, Sarah L. Ellis, Minna-Liisa Anko, Susan K. Nilsson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Megakaryocytes (MK) generate platelets. Recently, we and others, have reported MK also regulate hematopoietic stem cells (HSC). Here we show high ploidy large cytoplasmic megakaryocytes (LCM) are critical negative regulators of HSC and criti
Externí odkaz:
https://doaj.org/article/7defb2ab48b547d0b668ad9675392191
Publikováno v:
Metabolism. 40:146-149
Several recent studies suggest that vitamin C (ascorbic acid [AA]) status may be altered in insulin-dependent diabetes mellitus (IDDM). We measured the AA content of mononuclear leukocytes (MN-AA) as an indicator of tissue vitamin C status in adults
Publikováno v:
European journal of biochemistry. 256(1)
A heterozygous deletion of a single base (A4704) from exon 37 of the fibrillin-1 gene was defined in a patient with Marfan syndrome and subsequently in his previously undiagnosed father. The deletion created a cryptic 5' splice site in exon 37 which