Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sarah L Christensen"'
Autor:
Charlotte Ernstsen, Sarah L Christensen, Rikke H Rasmussen, Brian S Nielsen, Inger Jansen-Olesen, Jes Olesen, David M Kristensen
Publikováno v:
Brain. 145:2450-2460
Calcitonin gene-related peptide (CGRP)-antagonizing drugs represent a major advance in migraine treatment. However, up to 50% of patients do not benefit from monoclonal antibodies against CGRP or its receptor. Here, we test the hypothesis that a clos
Publikováno v:
Journal of visualized experiments : JoVE. (183)
Calcitonin gene-related peptide (CGRP) was first discovered in the 1980s as a splice variant from the calcitonin gene. Since its discovery, its role in migraine pathophysiology has been well established, first by its potent vasodilator properties and
Publikováno v:
Journal of Visualized Experiments.
Autor:
Gordon Munro, Inger Jansen-Olesen, David Møbjerg Kristensen, Steffen E. Petersen, Anmool Shabir, Sarah L Christensen, Jes Olesen
Publikováno v:
Cephalalgia. 40:650-664
Background Recently, the adenosine triphosphate (ATP) sensitive potassium channel opener levcromakalim was shown to induce migraine attacks with a far higher incidence than any previous provoking agent such as calcitonin gene-related peptide. Here, w
Von Frey testing revisited: Provision of an online algorithm for improved accuracy of 50% thresholds
Autor:
Thomas Hansen, Jes Olesen, Mikkel Ammentorp Storm, Rie Bager Hansen, Michael H. Ossipov, David Møbjerg Kristensen, Frank Porreca, Sarah L Christensen, Jose M. G. Izarzugaza
Publikováno v:
Christensen, S L, Hansen, R B, Storm, M A, Olesen, J, Hansen, T F, Ossipov, M, Izarzugaza, J M G, Porreca, F & Kristensen, D M 2020, ' Von Frey testing revisited: Provision of an online algorithm for improved accuracy of 50% thresholds ', European Journal of Pain, vol. 24, no. 4, pp. 783-790 . https://doi.org/10.1002/ejp.1528
Christensen, S L, Hansen, R B, Storm, M A, Olesen, J, Hansen, T F, Ossipov, M, Izarzugaza, J M G, Porreca, F & Kristensen, D M 2020, ' Von Frey testing revisited: Provision of an online algorithm for improved accuracy of 50% thresholds ', European Journal of Pain, vol. 24, pp. 783–790 . https://doi.org/10.1002/ejp.1528
Christensen, S L, Hansen, R B, Storm, M A, Olesen, J, Hansen, T F, Ossipov, M, Izarzugaza, J M G, Porreca, F & Kristensen, D M 2020, ' Von Frey testing revisited: Provision of an online algorithm for improved accuracy of 50% thresholds ', European Journal of Pain, vol. 24, pp. 783–790 . https://doi.org/10.1002/ejp.1528
Background: In the pain field, it is essential to quantify nociceptive responses. The response to the application of von Frey filaments to the skin measures tactile sensitivity and is a surrogate marker of allodynia in states of peripheral and/or cen
Autor:
Rikke H Rasmussen, Søren T. Christensen, Jes Olesen, Sanne La Cour, Jade Chaker, Sarah L Christensen, Kristian Agmund Haanes, David Møbjerg Kristensen, Charlotte Ernstsen, Arthur David
Publikováno v:
Cephalalgia
Cephalalgia, SAGE Publications, 2021, pp.033310242110388. ⟨10.1177/03331024211038884⟩
Cephalalgia, 2021, 41 (14), pp.1413-1426. ⟨10.1177/03331024211038884⟩
Cephalalgia, SAGE Publications, 2021, pp.033310242110388. ⟨10.1177/03331024211038884⟩
Cephalalgia, 2021, 41 (14), pp.1413-1426. ⟨10.1177/03331024211038884⟩
Background Knowledge of exact signalling events during migraine attacks is lacking. Various substances are known to trigger migraine attacks in patients and calcitonin gene-related peptide antagonising drugs are effective against migraine pain. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bcafdfaecaafc1d052c34b91067143d
https://hal.ehesp.fr/hal-03325044
https://hal.ehesp.fr/hal-03325044
Publikováno v:
Cephalalgia : an international journal of headache. 41(3)
Introduction Despite recent advances in migraine treatment there is a need for therapies with higher clinical efficacy and/or fewer side effects. Triptans (5-HT1B/1D/1F agonists) are essential in the present treatment regime and gepants (CGRP-recepto
Autor:
Sarah L, Christensen, Gordon, Munro, Steffen, Petersen, Anmool, Shabir, Inger, Jansen-Olesen, David M, Kristensen, Jes, Olesen
Publikováno v:
Cephalalgia : an international journal of headache. 40(7)
Recently, the adenosine triphosphate (ATP) sensitive potassium channel opener levcromakalim was shown to induce migraine attacks with a far higher incidence than any previous provoking agent such as calcitonin gene-related peptide. Here, we show effi
Publikováno v:
Cephalalgia : an international journal of headache. 40(9)
IntroductionClinically, calcitonin gene-related peptide antagonising drugs are recognized as effective in migraine treatment, but their site of action is debated. Only a small fraction of these compounds pass the blood-brain barrier and accesses the
Autor:
Sarah L Christensen, Inger Jansen-Olesen, Steffen E. Petersen, Dorte Bratbo Sørensen, Jes Olesen
Publikováno v:
Cephalalgia. 38:452-465
Introduction Research in development of new migraine therapeutics is hindered by the lack of suitable, predictive animal models. Cilostazol provokes headache in healthy humans and migraineurs by increasing intracellular cAMP levels. We aimed to inves