Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Sarah L, Maslen"'
Autor:
Yuteng Wu, M. Teresa Bertran, Dhira Joshi, Sarah L. Maslen, Catherine Hurd, Louise J. Walport
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-9 (2023)
Abstract Photoaffinity labelling is a promising method for studying protein-ligand interactions. However, obtaining a specific, efficient crosslinker can require significant optimisation. We report a modified mRNA display strategy, photocrosslinking-
Externí odkaz:
https://doaj.org/article/ac80405cd43a480cbf4202f8da9ed517
Autor:
Leo Kiss, Tyler Rhinesmith, Jakub Luptak, Claire F. Dickson, Jonas Weidenhausen, Shannon Smyly, Ji-Chun Yang, Sarah L. Maslen, Irmgard Sinning, David Neuhaus, Dean Clift, Leo C. James
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract TRIM proteins are the largest family of E3 ligases in mammals. They include the intracellular antibody receptor TRIM21, which is responsible for mediating targeted protein degradation during Trim-Away. Despite their importance, the ubiquitin
Externí odkaz:
https://doaj.org/article/9847497c03534f53b81f80ff92484d91
Autor:
Elyse S. Fischer, Conny W. H. Yu, Johannes F. Hevler, Stephen H. McLaughlin, Sarah L. Maslen, Albert J. R. Heck, Stefan M. V. Freund, David Barford
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Formation of the mitotic checkpoint complex (MCC) is catalysed by a phosphorylation-dependent scaffold. This work provides structural details of how a tripartite Mad1:Bub1:Cdc20 complex presents Cdc20 to Mad2, triggering open-to-closed conversion of
Externí odkaz:
https://doaj.org/article/25af90ef4aa84deab038bcc19c9bacc5
Autor:
Jérôme Cattin-Ortolá, Lawrence G. Welch, Sarah L. Maslen, Guido Papa, Leo C. James, Sean Munro
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The Spike protein of SARS-CoV-2 has a C-terminal cytoplasmic tail. Here the authors show that this tail binds trafficking machinery via sequences that appear optimised to ensure that Spike accumulates at the site of viral budding in the Golgi but tha
Externí odkaz:
https://doaj.org/article/fbd2667f0c0d43b0837fb514639c3ee9
Autor:
Shirley Tremel, Yohei Ohashi, Dustin R. Morado, Jessie Bertram, Olga Perisic, Laura T. L. Brandt, Marie-Kristin von Wrisberg, Zhuo A. Chen, Sarah L. Maslen, Oleksiy Kovtun, Mark Skehel, Juri Rappsilber, Kathrin Lang, Sean Munro, John A. G. Briggs, Roger L. Williams
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The phosphatidylinositol-3-phosphate (PI3P) is generated by the lipid kinase VPS34, in the context of VPS34 complex I on autophagosomes or complex II on endosomes. Biochemical and structural analyses provide insights into the mechanism of both VPS34
Externí odkaz:
https://doaj.org/article/d0b77c3d6f3f4cfcbbaf6326c8d008f3
Autor:
Tim Nierhaus, Stephen H. McLaughlin, Frank Bürmann, Danguole Kureisaite-Ciziene, Sarah L. Maslen, J. Mark Skehel, Conny W. H. Yu, Stefan M. V. Freund, Louise F. H. Funke, Jason W. Chin, Jan Löwe
Publikováno v:
Nature Microbiology. 7:1686-1701
During bacterial cell division, filaments of tubulin-like FtsZ form the Z-ring, which is the cytoplasmic scaffold for divisome assembly. In Escherichia coli, the actin homologue FtsA anchors the Z-ring to the membrane and recruits divisome components
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c86d9870695cc5a6de38f025a15dd11
https://doi.org/10.1038/s41564-022-01206-9
https://doi.org/10.1038/s41564-022-01206-9
Autor:
Soledad Baños-Mateos, Anne-Marie M. van Roon, Ulla F. Lang, Sarah L. Maslen, J. Mark Skehel, Meindert H. Lamers
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
The polymerase and histidinol phosphatase (PHP) domain in the DNA polymerase DnaE1 is essential for mycobacterial high-fidelity DNA replication. Here, the authors determine the DnaE1 crystal structure, which reveals the PHP-exonuclease mechanism that
Externí odkaz:
https://doaj.org/article/5fc944f0ddb6405aa8447da27bcce74f
Autor:
Sarah L. Maslen, Salvador Buse, Martin Spinck, Louise F. H. Funke, Daniel de la Torre, George P. C. Salmond, Wesley E. Robertson, Thomas S. Elliott, Franz L. Böge, Daniele Cervettini, Julius Fredens, Jason W. Chin, Yonka Christova, Kim C. Liu
Publikováno v:
Science. 372:1057-1062
Designing bacterial superpowers Biological systems read all 64 triplet codons in DNA to encode the synthesis of proteins composed of 20 canonical amino acids. Robertson et al. created cells that do not read several codons and showed that this confers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5f1add2abd9e8d7046f897f7ff53b62
https://doi.org/10.1126/science.abg3029
https://doi.org/10.1126/science.abg3029
Autor:
Leo Kiss, Tyler Rhinesmith, Claire F Dickson, Jonas Weidenhausen, Shannon Smyly, Jakub Luptak, Ji-Chun Yang, Sarah L Maslen, Irmgard Sinning, David Neuhaus, Dean Clift, Leo C James
TRIM proteins are the largest family of E3 ligases in mammals. They include the intracellular antibody receptor TRIM21, which is responsible for mediating targeted protein degradation during Trim-Away. Despite their importance, the ubiquitination mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ff087e88dc61ef593889cbe848b8038
https://doi.org/10.1101/2022.06.29.498105
https://doi.org/10.1101/2022.06.29.498105
Autor:
Sarah L. Maslen, Shun-ichiro Oda, Frank Adolf, Yorgo Modis, Iva A. Tchasovnikarova, Christopher H. Douse, Paul J. Lehner, Daniil M. Prigozhin, Stefan M.V. Freund, Anna Albecka, Laura E. Farleigh, Richard T. Timms
Publikováno v:
Nucleic Acids Research
Nucleic acids research, vol 48, iss 18
Nucleic acids research, vol 48, iss 18
Transcription of integrated DNA from viruses or transposable elements is tightly regulated to prevent pathogenesis. The Human Silencing Hub (HUSH), composed of Periphilin, TASOR and MPP8, silences transcriptionally active viral and endogenous transge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d7a7e021878369da884bca65918e500
http://europepmc.org/articles/PMC7544229
http://europepmc.org/articles/PMC7544229