Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens

Autor: Sarah L. Jongbloed, Xinsheng Ju, P. Rod Dunbar, Kylie J. McDonald, Robert Wadley, Kristen J. Radford, Varinder Jeet, Annelie J.E. Vulink, Andrew J. Kassianos, Georgina J. Clark, Derek N.J. Hart, Chun-Jen J. Chen, Catherine E. Angel

Publikováno v: The Journal of Experimental Medicine

The characterization of human dendritic cell (DC) subsets is essential for the design of new vaccines. We report the first detailed functional analysis of the human CD141+ DC subset. CD141+ DCs are found in human lymph nodes, bone marrow, tonsil, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::292af8442f256c2d93283d91298f467a
https://doi.org/10.1084/jem.20092140

Isolation of human blood DC subtypes

Autor: Andrew J, Kassianos, Sarah L, Jongbloed, Derek N J, Hart, Kristen J, Radford

Publikováno v: Methods in molecular biology (Clifton, N.J.). 595

Human blood dendritic cells (DCs) are a rare, heterogeneous cell population that comprise approximately 1% of circulating peripheral blood mononuclear cells (PBMCs). Their isolation has been confounded by their scarcity and lack of distinguishing mar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d619a7af8c58e371795fc75f2029396a
https://pubmed.ncbi.nlm.nih.gov/19941104

Plasmacytoid dendritic cells regulate breach of self-tolerance in autoimmune arthritis

Autor: James M. Brewer, Sarah L. Jongbloed, Iain B. McInnes, Mohammed B. Nickdel, Paul Garside, Robert A. Benson

Publikováno v: ResearcherID

Achieving remission in rheumatoid arthritis (RA) remains elusive despite current biological therapeutics. Consequently, interest has increased in strategies to re-establish immune tolerance to provide long-term disease suppression. Although dendritic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359c32710364fbec2ab5fad49bf96025
https://pubmed.ncbi.nlm.nih.gov/19124739

Targeting interleukin-15 in patients with rheumatoid arthritis: a proof-of-concept study

Autor: Per Larsson, Paul W. H. I. Parren, Bo Baslund, Gabriel S. Panayi, Bente Danneskiold-Samsøe, Jan G. J. van de Winkel, J. Alastair Gracie, Foo Y. Liew, Niels Tvede, Joergen Petersen, Frank J. Beurskens, Iain B. McInnes, Sarah L. Jongbloed, Lars Jelstrup Petersen, Janine Schuurman

Publikováno v: Baslund, B, Tvede, N, Danneskiold-Samsoe, B, Larsson, P, Panayi, G, Petersen, J, Petersen, L J, Beurskens, F J M, Schuurman, J, van de Winkel, J G J, Parren, P W H I, Gracie, J A, Jongbloed, S, Liew, F Y & McInnes, I B 2005, ' Targeting interleukin-15 in patients with rheumatoid arthritis: a proof-of-concept study ' Arthritis & Rheumatism, vol. 52, no. 9, pp. 2686-92 . https://doi.org/10.1002/art.21249

Objective Interleukin-15 (IL-15) is a proinflammatory, innate response cytokine that mediates pleiotropic effector function in rheumatoid arthritis (RA) inflammatory synovitis. Our objective was to study the ability of HuMax-IL15, a human IgG1 anti�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a579a8dbf34f08d6e15bcbf2df76cb
https://pure.au.dk/portal/da/publications/targeting-interleukin15-in-patients-with-rheumatoid-arthritis-a-proofofconcept-study(8ad24009-999f-4a09-8ceb-8ad39f6f70ff).html

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Autor: J. Alastair Gracie, Iain B. McInnes, Alasdair R. Fraser, Paul P. Tak, M Cristina Lebre, Sarah L. Jongbloed, Roger D. Sturrock

Publikováno v: Arthritis Research & Therapy. 8:R15

Dendritic cells (DCs) comprise heterogeneous subsets of professional antigen-presenting cells, linking innate and adaptive immunity. Analysis of DC subsets has been hampered by a lack of specific DC markers and reliable quantitation assays. We charac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::886341f7761d415105222dc208e0c04a
https://doi.org/10.1186/ar1864