Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Sarah L, Gaffen"'
Autor:
Felix E Y Aggor, Martinna Bertolini, Bianca M Coleman, Tiffany C Taylor, Nicole O Ponde, Sarah L Gaffen
Publikováno v:
PLoS Pathogens, Vol 20, Iss 7, p e1012302 (2024)
Oropharyngeal candidiasis (OPC) is the most common human fungal infection, arising typically from T cell immune impairments. IL-17 and IL-22 contribute individually to OPC responses, but here we demonstrate that the combined actions of both cytokines
Externí odkaz:
https://doaj.org/article/00057ee8a517475cb226bbae4236d470
Autor:
Felix E.Y. Aggor, Martinna Bertolini, Chunsheng Zhou, Tiffany C. Taylor, Darryl A. Abbott, Javonn Musgrove, Vincent M. Bruno, Timothy W. Hand, Sarah L. Gaffen
Publikováno v:
JCI Insight, Vol 7, Iss 18 (2022)
A side effect of antibiotics is outgrowth of the opportunistic fungus Candida albicans in the oropharynx (oropharyngeal candidiasis, OPC). IL-17 signaling is vital for immunity to OPC, but how the microbiome impacts antifungal immunity is not well un
Externí odkaz:
https://doaj.org/article/3e7129f8a12d4d8baf5f4651693398d2
Autor:
Rami Bechara, Nilesh Amatya, Saikat Majumder, Chunsheng Zhou, Yang Li, Qixing Liu, Mandy J. McGeachy, Sarah L. Gaffen
Publikováno v:
JCI Insight, Vol 7, Iss 3 (2022)
Stromal cells are emerging as key drivers of autoimmunity, partially because they produce inflammatory chemokines that orchestrate inflammation. Chemokine expression is regulated transcriptionally but also through posttranscriptional mechanisms, the
Externí odkaz:
https://doaj.org/article/071c9084a6c34ebbb2a47971faa2c091
Autor:
Giraldina Trevejo-Nuñez, Becky Lin, Li Fan, Felix E. Y. Aggor, Partha S. Biswas, Kong Chen, Sarah L. Gaffen
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Excessive inflammation can cause tissue damage and autoimmunity, sometimes accompanied by severe morbidity or mortality. Numerous negative feedback mechanisms exist to prevent unchecked inflammation, but this restraint may come at the cost o
Externí odkaz:
https://doaj.org/article/fed2f4fe08da4049bb712d406820443e
Autor:
Quynh T. Phan, Jianfeng Lin, Norma V. Solis, Michael Eng, Marc Swidergall, Feng Wang, Shan Li, Sarah L. Gaffen, Tsui-Fen Chou, Scott G. Filler
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT During oropharyngeal candidiasis, Candida albicans activates the epidermal growth factor receptor (EGFR), which induces oral epithelial cells to endocytose the fungus and synthesize proinflammatory mediators. To elucidate EGFR signaling path
Externí odkaz:
https://doaj.org/article/c544eeaa51c54fd4abc82c144d5e9d84
Autor:
De-Dong Li, Rami Bechara, Kritika Ramani, Chetan V. Jawale, Yang Li, Jay K. Kolls, Sarah L. Gaffen, Partha S. Biswas
Publikováno v:
JCI Insight, Vol 6, Iss 13 (2021)
Antibody-mediated glomerulonephritis (AGN) is a clinical manifestation of many autoimmune kidney diseases for which few effective treatments exist. Chronic inflammatory circuits in renal glomerular and tubular cells lead to tissue damage in AGN. Thes
Externí odkaz:
https://doaj.org/article/2627b0a0ff314189a690b02dfd4c019a
Autor:
Jemima Ho, Xuexin Yang, Spyridoula-Angeliki Nikou, Nessim Kichik, Andrew Donkin, Nicole O. Ponde, Jonathan P. Richardson, Remi L. Gratacap, Linda S. Archambault, Christian P. Zwirner, Celia Murciano, Rhonda Henley-Smith, Selvam Thavaraj, Christopher J. Tynan, Sarah L. Gaffen, Bernhard Hube, Robert T. Wheeler, David L. Moyes, Julian R. Naglik
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Candida albicans is an opportunistic fungus primarily affecting immunocompromised patients. Here, the authors identify a novel mechanism of host immune stimulation and highlight candidalysin and EGFR signalling components as potential targets for pro
Externí odkaz:
https://doaj.org/article/5a35ef4f63da4f5da3fd3d4b2fc4fa96
Publikováno v:
Cell. 186:466-468
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c24632494c9dae51229892bc36316195
https://doi.org/10.1016/j.cell.2022.12.048
https://doi.org/10.1016/j.cell.2022.12.048
Autor:
Rami Bechara, Sarah L. Gaffen
Publikováno v:
Trends Immunol
Covalent modifications of RNA that regulate gene expression post-transcriptionally, in particular N6-methyladenosine (m(6)A), are emerging as important regulators of autoimmune responses. This article highlights new findings describing the functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bdb19e8e312edf0e9b278eb78ec0e9b
https://doi.org/10.1016/j.it.2021.10.002
https://doi.org/10.1016/j.it.2021.10.002
Autor:
Ian D. Ferguson, Patricia Griffin, Joshua J. Michel, Hiroshi Yano, Sarah L. Gaffen, Robert G. Mueller, Jeffrey A. Dvergsten, Jon D. Piganelli, Margalit E. Rosenkranz, Daniel A. Kietz, Abbe N. Vallejo
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
T cells are considered autoimmune effectors in juvenile idiopathic arthritis (JIA), but the antigenic cause of arthritis remains elusive. Since T cells comprise a significant proportion of joint-infiltrating cells, we examined whether the environment
Externí odkaz:
https://doaj.org/article/757c2d5e02994195bbce2ee52debeb3b