Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Sarah L'Heureux"'
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/cfa46c1888d04b25a6a8605e67ab5f55
Autor:
Miguel Aste-Amézaga, Ningyan Zhang, Janet E Lineberger, Beth A Arnold, Timothy J Toner, Mingcheng Gu, Lingyi Huang, Salvatore Vitelli, Kim T Vo, Peter Haytko, Jing Zhang Zhao, Frederic Baleydier, Sarah L'Heureux, Hongfang Wang, Wendy R Gordon, Elizabeth Thoryk, Marie Blanke Andrawes, Kittichoat Tiyanont, Kimberly Stegmaier, Giovanni Roti, Kenneth N Ross, Laura L Franlin, Hui Wang, Fubao Wang, Michael Chastain, Andrew J Bett, Laurent P Audoly, Jon C Aster, Stephen C Blacklow, Hans E Huber
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9094 (2010)
Notch receptors normally play a key role in guiding a variety of cell fate decisions during development and differentiation of metazoan organisms. On the other hand, dysregulation of Notch1 signaling is associated with many different types of cancer
Externí odkaz:
https://doaj.org/article/b4ac98e727c04ff3ad08212b68b47d08
Autor:
Wendy R Gordon, Didem Vardar-Ulu, Sarah L'Heureux, Todd Ashworth, Michael J Malecki, Cheryll Sanchez-Irizarry, Debbie G McArthur, Gavin Histen, Jennifer L Mitchell, Jon C Aster, Stephen C Blacklow
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6613 (2009)
Notch receptors are normally cleaved during maturation by a furin-like protease at an extracellular site termed S1, creating a heterodimer of non-covalently associated subunits. The S1 site lies within a key negative regulatory region (NRR) of the re
Externí odkaz:
https://doaj.org/article/bd8fa4227a984c5fb57219385262de3b
Autor:
Amrik Singh, Sarah L'Heureux, Ryan Sinapius, Michael Kvorjak, Emma Wade, Jason Lohmueller, Jeremy Fisher, Reginaldo Prioli
Publikováno v:
Cancer Research. 83:898-898
Introduction: Chimeric Antigen Receptor (CAR)-T cell therapy is a highly innovative form of immunotherapy that has proven to be successful in the treatment of B cell malignancies and multiple myeloma. As this treatment modality continues to evolve to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7fbfe2b84266c15f5cc069117482e5e
https://doi.org/10.1158/1538-7445.am2023-898
https://doi.org/10.1158/1538-7445.am2023-898
Autor:
Sarah L'Heureux, Ningyan Zhang, Janet Lineberger, Kittichoat Tiyanont, Hui Wang, Fubao Wang, Wendy R. Gordon, Jon C. Aster, Hans E. Huber, Lingyi Huang, Salvatore Vitelli, Laurent P. Audoly, Kenneth N. Ross, Kim Vo, Elizabeth Thoryk, Miguel Aste-Amezaga, Stephen C. Blacklow, Timothy J. Toner, Peter Haytko, Beth A. Arnold, Marie Blanke Andrawes, Kimberly Stegmaier, Jing Zhang Zhao, Mingcheng Gu, Michael Chastain, Hongfang Wang, Giovanni Roti, Frederic Baleydier, Laura L. Franlin, Andrew J. Bett
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9094 (2010)
PLoS ONE
PLoS ONE
Background Notch receptors normally play a key role in guiding a variety of cell fate decisions during development and differentiation of metazoan organisms. On the other hand, dysregulation of Notch1 signaling is associated with many different types
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d172778b2828cb3442ce709acb47a69
http://hdl.handle.net/11391/1215082
http://hdl.handle.net/11391/1215082
Autor:
Michael J. Malecki, Sarah L'Heureux, Didem Vardar-Ulu, Jennifer L. Mitchell, Todd Ashworth, Wendy R. Gordon, Cheryll Sanchez-Irizarry, Stephen C. Blacklow, Debbie G. McArthur, Gavin Histen, Jon C. Aster
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6613 (2009)
PLoS ONE
PLoS ONE
Background Notch receptors are normally cleaved during maturation by a furin-like protease at an extracellular site termed S1, creating a heterodimer of non-covalently associated subunits. The S1 site lies within a key negative regulatory region (NRR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38bb60944f313482ebab1c044c1809e
http://europepmc.org/articles/PMC2726630?pdf=render
http://europepmc.org/articles/PMC2726630?pdf=render
Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia
Autor:
Sarah L'Heureux, Candice Romany, Olga Shestova, M. Eden Childs, Phyllis A. Gimotty, Lanwei Xu, Warren S. Pear, Mark Y. Chiang, Gavin Histen, Jon C. Aster
Publikováno v:
The Journal of clinical investigation. 118(9)
Gain-of-function NOTCH1 mutations are found in 50%-70% of human T cell acute lymphoblastic leukemia/lymphoma (T-ALL) cases. Gain-of-function NOTCH1 alleles that initiate strong downstream signals induce leukemia in mice, but it is unknown whether the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed0de3af19d392d6925b24f1e6baf07
https://pubmed.ncbi.nlm.nih.gov/18677410
https://pubmed.ncbi.nlm.nih.gov/18677410