Výsledky vyhledávání - "Sarah Krantz"

Akademický článek

Caveolin-1 controls mitochondrial damage and ROS production by regulating fission - fusion dynamics and mitophagy

Autor: Ying Jiang, Sarah Krantz, Xiang Qin, Shun Li, Hirushi Gunasekara, Young-Mee Kim, Adriana Zimnicka, Misuk Bae, Ke Ma, Peter T. Toth, Ying Hu, Ayesha N. Shajahan-Haq, Hemal H. Patel, Saverio Gentile, Marcelo G. Bonini, Jalees Rehman, Yiyao Liu, Richard D. Minshall

Publikováno v: Redox Biology, Vol 52, Iss , Pp 102304- (2022)

As essential regulators of mitochondrial quality control, mitochondrial dynamics and mitophagy play key roles in maintenance of metabolic health and cellular homeostasis. Here we show that knockdown of the membrane-inserted scaffolding and structural

Externí odkaz: https://doaj.org/article/5ff54eba886243c59a38ab64bfa4363d

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Akademický článek

Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling

Autor: Young-Mee Kim, Sarah Krantz, Ankit Jambusaria, Peter T. Toth, Hyung-Geun Moon, Isuru Gunarathna, Gye Young Park, Jalees Rehman

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Endothelial tissues must have intact barrier function, but this may be disrupted during inflammation. Here, the authors show that the mitochondrial protein Mitofusin-2 stabilizes cell–cell adherens junctions in endothelial cells during homeostasis

Externí odkaz: https://doaj.org/article/e5953cf98299418595f144ad5dbc7489

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Parallel Activation of Src and Hif1α Increases Localized Glycolytic ATP Generation for Re-assembly of Endothelial Adherens Junctions

Autor: Li Wang, Priyanka Gajwani, Pallavi Chaturvedi, Zhigang Hong, Zijing Ye, Gregory J. Schwarz, Nicole M. Pohl-Avila, Anne-Marie Ray, Sarah Krantz, Peter T Toth, Deborah E. Leckband, Andrei Karginov, Jalees Rehman

Endothelial adherens junctions (AJs) are critical for the regulation of vascular barrier integrity and undergo dis-assembly during inflammatory injury, thus causing vascular leakiness. AJ re-assembly is thus necessary for restoration of the endotheli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2bf4c77760cee74e7d7a620522675a4f
https://doi.org/10.1101/2022.11.11.516184

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Pink1-mediated mitophagy in the endothelium releases proteins encoded by mitochondrial DNA and activates neutrophil responses

Autor: Priyanka Gajwani, Li Wang, Shubhi Srivastava, Zijing Ye, Young-Mee Kim, Sarah Krantz, Dong-Mei Wang, Chinnaswamy Tiruppathi, Peter T. Toth, Jalees Rehman

Given their ancient evolutionary origins, eukaryotic mitochondria possess multiple vestiges of their prokaryotic ancestors. One such factor is the N-terminal formylation of proteins encoded by mitochondrial DNA. N-formylated proteins are also release

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf6c280b548416cd9ebcc583fa1b97ac
https://doi.org/10.1101/2022.08.07.503084

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