Advanced bioinformatics rapidly identifies existing therapeutics for patients with coronavirus disease-2019 (COVID-19)

Autor: Jason Kim, Jenny Zhang, Yoonjeong Cha, Sarah Kolitz, Jason Funt, Renan Escalante Chong, Scott Barrett, Rebecca Kusko, Ben Zeskind, Howard Kaufman

Publikováno v: Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-9 (2020)

Abstract Background The recent global pandemic has placed a high priority on identifying drugs to prevent or lessen clinical infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), caused by Coronavirus disease-2019 (COVID-19). Met

Externí odkaz: https://doaj.org/article/5e03850ec52842f0a739b14d52636f37

449 Cyclic disruption of the mitogen-activated protein kinase (MAPK) pathway by the dual MEK inhibitor, IMM-6-415, enhances PD1 and CTLA4 checkpoint blockade in RAS mutant tumors

Autor: Brett Hall, Anna Travesa, Amy Yamamura, Amy Axel, Sarah Kolitz, Jason Funt, Kevin Fowler, Matthew Nord, Praveen Nair, Scott Barrett, Benjamin Zeskind, Peter King

Publikováno v: Regular and Young Investigator Award Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ef201f7af53d1105191504ed2251bdb
https://doi.org/10.1136/jitc-2022-sitc2022.0449

Advanced bioinformatics rapidly identifies existing therapeutics for patients with coronavirus disease-2019 (COVID-19)

Autor: Sarah Kolitz, Renan Escalante Chong, Yoonjeong Cha, Howard L. Kaufman, Ben Zeskind, Jason M. Funt, Jenny Zhang, Scott Barrett, Rebecca Kusko, Jason K. Kim

Publikováno v: Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-9 (2020)
Journal of translational medicine, 18(1):257
Journal of Translational Medicine

Background The recent global pandemic has placed a high priority on identifying drugs to prevent or lessen clinical infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), caused by Coronavirus disease-2019 (COVID-19). Methods We a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e53e69f21261cd1bc5628b30221eca4b
http://link.springer.com/article/10.1186/s12967-020-02430-9

Translational modeling for patients with RAS mutant tumors: Profiling the dual-MEK inhibitor IMM-1-104 in a humanized 3D assay

Autor: Brett Hall, Praveen Nair, Kevin Fowler, Amy Axel, Sarah Kolitz, Jason Funt, Scott Barrett, Benjamin Zeskind, Peter J. King

Publikováno v: Journal of Clinical Oncology. 40:e15084-e15084

e15084 Background: Elevated RAS-RAF-MEK-ERK (MAPK pathway) signaling is observed in over half of all solid human tumors, and mutations in RAS or RAF account for a large fraction. Given MEK’s unique position in the MAPK cascade, it remains an attrac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1034fdf9b30aee4b6696580ab87ed0f2
https://doi.org/10.1200/jco.2022.40.16_suppl.e15084

664 Applying advanced data analysis to immunotherapy drug discovery for Uveal Melanoma

Autor: Sailaja Battula, Howard L. Kaufman, Benjamin Zeskind, Yoonjeong Cha, Sarah Kolitz, Rebecca Kusko

Publikováno v: Regular and young investigator award abstracts.

Background Uveal melanoma is a rare variant of melanoma associated with monosomy 3, present high risk for metastatic disease, and has been resistant to all therapeutic approaches. We sought to use a novel advanced big data approach to identify potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ad14b37062f3b093fe5d6bfbd3012d0
https://doi.org/10.1136/jitc-2020-sitc2020.0664