Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Sarah Killcoyne"'
Autor:
Kenza Bouzid, Harshita Sharma, Sarah Killcoyne, Daniel C. Castro, Anton Schwaighofer, Max Ilse, Valentina Salvatelli, Ozan Oktay, Sumanth Murthy, Lucas Bordeaux, Luiza Moore, Maria O’Donovan, Anja Thieme, Aditya Nori, Marcel Gehrung, Javier Alvarez-Valle
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Timely detection of Barrett’s esophagus, the pre-malignant condition of esophageal adenocarcinoma, can improve patient survival rates. The Cytosponge-TFF3 test, a non-endoscopic minimally invasive procedure, has been used for diagnosing in
Externí odkaz:
https://doaj.org/article/a7d26ad27adf4210ba573b93bfdee22b
Autor:
Sujath Abbas, Oriol Pich, Ginny Devonshire, Shahriar A. Zamani, Annalise Katz-Summercorn, Sarah Killcoyne, Calvin Cheah, Barbara Nutzinger, Nicola Grehan, Nuria Lopez-Bigas, OCCAMS Consortium, Rebecca C. Fitzgerald, Maria Secrier
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract A variety of mutational processes drive cancer development, but their dynamics across the entire disease spectrum from pre-cancerous to advanced neoplasia are poorly understood. We explore the mutagenic processes shaping oesophageal adenocar
Externí odkaz:
https://doaj.org/article/80b7ae7055464931a7d92bf9f8491937
Autor:
Alvin Wei Tian Ng, Gianmarco Contino, Sarah Killcoyne, Ginny Devonshire, Ray Hsu, Sujath Abbas, Jing Su, Aisling M. Redmond, Jamie M. J. Weaver, Matthew D. Eldridge, Simon Tavaré, Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium, Paul A. W. Edwards, Rebecca C. Fitzgerald
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Genomic structural variants (SVs) in cancer are notoriously difficult to identify, despite the impact they have on cancer progression and treatment efficacy. This study applies state-of-the-art computational methods to catalogue SVs in 383 cases of o
Externí odkaz:
https://doaj.org/article/0336bd3704d7461197a30b2d9ac48316
Autor:
Andreas V. Hadjinicolaou, Sanne N. van Munster, Achilleas Achilleos, Jose Santiago Garcia, Sarah Killcoyne, Krish Ragunath, Jacques J.G.H.M. Bergman, Rebecca C. Fitzgerald, Massimiliano di Pietro
Publikováno v:
EBioMedicine, Vol 56, Iss , Pp 102765- (2020)
Background: The cancer risk in Barrett's oesophagus (BO) is difficult to estimate. Histologic dysplasia has strong predictive power, but can be missed by random biopsies. Other clinical parameters have limited utility for risk stratification. We aime
Externí odkaz:
https://doaj.org/article/a37c76af296b48379e099fd2e9eb945a
Autor:
Rebecca Landy, Sarah Killcoyne, Charlene Tang, Stephanie Juniat, Maria O’Donovan, Neha Goel, Marcel Gehrung, Rebecca C Fitzgerald
Publikováno v:
QJM: An International Journal of Medicine.
Background COVID-19 curtailed endoscopy services adding to diagnostic backlogs. Building on trial evidence for a non-endoscopic oesophageal cell collection device coupled with biomarkers (Cytosponge), a pilot implementation was launched for patients
Autor:
Dmitry A. Gordenin, Jesse R. Dixon, Sarah Killcoyne, Erica Lynn, Peter J. Campbell, Manjunath Nimmakayalu, Rebecca C. Fitzgerald, Yanyan Tian, Sahil Seth, Yonathan Lissanu Deribe, John P. O'Brien, Akira Inoue, Victoria T. Le, Roel G.W. Verhaak, Kadir C. Akdemir, Leszek J. Klimczak, Moritz Gerstung, Rafael E. Herrera, Ya-Ping Lin, Lei Li, Justin M. Kim, Samirkumar B. Amin, P. Andrew Futreal, Frederick S. Robinson, Kin Chan, Ashby J. Morrison, Devin A. King
Publikováno v:
Nat Genet
Somatic mutations in driver genes may ultimately lead to the development of cancer. Understanding how somatic mutations accumulate in cancer genomes and the underlying factors that generate somatic mutations is therefore crucial for developing novel
Autor:
Alvin Wei Tian, Ng, Gianmarco, Contino, Sarah, Killcoyne, Ginny, Devonshire, Ray, Hsu, Sujath, Abbas, Jing, Su, Aisling M, Redmond, Jamie M J, Weaver, Matthew D, Eldridge, Simon, Tavaré, Paul A W, Edwards, Freddie, Bartlett
Publikováno v:
Communications biology. 5(1)
Oesophageal adenocarcinoma (OAC) provides an ideal case study to characterize large-scale rearrangements. Using whole genome short-read sequencing of 383 cases, for which 214 had matched whole transcriptomes, we observed structural variations (SV) wi
Publikováno v:
Nature reviews. Cancer. 21(11)
Cancer cells are shaped through an evolutionary process of DNA mutation, cell selection and population expansion. Early steps in this process are driven by a set of mutated driver genes and structural alterations to the genome through copy number gai
Autor:
Prasad G. Iyer, Shawn A. Zamani, Rebecca C. Fitzgerald, Kenneth K. Wang, David A. Katzka, Andrew Dullea, Tarek Sawas, Sarah Killcoyne
Publikováno v:
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 20(8)
Background & Aims Despite extensive Barrett’s esophagus (BE) screening efforts, most patients with esophageal adenocarcinoma (EAC) present de novo. It is unclear how much of this problem is the result of insensitivity or poor applications of curren
Autor:
Sarah Killcoyne, Rebecca C. Fitzgerald
Publikováno v:
British Journal of Cancer
SummaryBarrett’s oesophagus has been known for many years to display early changes to the genome consistent with the risk for oesophageal adenocarcinoma. Recently we have shown that this information can be used without knowledge of individual gene