Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sarah Kate Lane-Reticker"'
Autor:
Sarah Kate Lane-Reticker, Emily A. Kessler, Audrey J. Muscato, Sarah Y. Kim, John G. Doench, Kathleen B. Yates, Robert T. Manguso, Juan Dubrot
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102082- (2023)
Summary: Recognition of Cas9 and other proteins encoded in delivery vectors has limited CRISPR technology in vivo. Here, we present a protocol for genome engineering using selective CRISPR antigen removal (SCAR) lentiviral vectors in Renca mouse mode
Externí odkaz:
https://doaj.org/article/0c320af4e9ac4ab5a03b47a82bf988de
Autor:
Elisabeth A. Marnik, Xulong Wang, Thomas J. Sproule, Giljun Park, Gregory J. Christianson, Sarah Kate Lane-Reticker, Shweta Jain, Theodore Duffy, Hongsheng Wang, Gregory W. Carter, Herbert C. Morse, III, Derry C. Roopenian
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 208-221 (2017)
Interleukin 21 (IL-21) plays key roles in humoral immunity and autoimmune diseases. It is known to function in mature CD4+ T follicular B cell helper (TFH) cells, but its potential involvement in early T cell ontogeny is unclear. Here, we find that a
Externí odkaz:
https://doaj.org/article/8c5c925b9a49414d868f8ea10c5e174b
Autor:
Juan Dubrot, Peter P. Du, Sarah Kate Lane-Reticker, Emily A. Kessler, Audrey J. Muscato, Arnav Mehta, Samuel S. Freeman, Peter M. Allen, Kira E. Olander, Kyle M. Ockerman, Clara H. Wolfe, Fabius Wiesmann, Nelson H. Knudsen, Hsiao-Wei Tsao, Arvin Iracheta-Vellve, Emily M. Schneider, Andrea N. Rivera-Rosario, Ian C. Kohnle, Hans W. Pope, Austin Ayer, Gargi Mishra, Margaret D. Zimmer, Sarah Y. Kim, Animesh Mahapatra, Hakimeh Ebrahimi-Nik, Dennie T. Frederick, Genevieve M. Boland, W. Nicholas Haining, David E. Root, John G. Doench, Nir Hacohen, Kathleen B. Yates, Robert T. Manguso
Publikováno v:
Nature immunology. 23(10)
The immune system can eliminate tumors, but checkpoints enable immune escape. Here, we identify immune evasion mechanisms using genome-scale in vivo CRISPR screens across cancer models treated with immune checkpoint blockade (ICB). We identify immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2baea80423306b35717a112e6865b459
https://pubmed.ncbi.nlm.nih.gov/36151395
https://pubmed.ncbi.nlm.nih.gov/36151395
Autor:
John G. Doench, Flavian D. Brown, Dawn E. Comstock, Kathleen B. Yates, Juan Dubrot, Robert T. Manguso, Hans W. Pope, W. Nicholas Haining, Austin Ayer, Adrienne H. Long, Arpit Panda, Ian C. Kohnle, Peter P. Du, Margaret D. Zimmer, Erez Y. Levanon, Jeffrey J. Ishizuka, Gabriel K. Griffin, Sarah Kate Lane-Reticker, Kevin Bi, David Kozono, Ilana Buchumenski, Natalie B. Collins, Collins K. Cheruiyot, Brian C. Miller, Emily J. Robitschek, Debattama R. Sen, Arvin Iracheta-Vellve
Publikováno v:
Signal Transduction and Targeted Therapy
Most patients with cancer either do not respond to immune checkpoint blockade or develop resistance to it, often because of acquired mutations that impair antigen presentation. Here we show that loss of function of the RNA-editing enzyme ADAR1 in tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049eb68cbb778be01462895380b48dd6
https://doi.org/10.1038/s41586-018-0768-9
https://doi.org/10.1038/s41586-018-0768-9
Autor:
Gregory J. Christianson, Gregory W. Carter, Thomas J. Sproule, Theodore Duffy, Giljun Park, Shweta Jain, Derry C. Roopenian, Herbert C. Morse, Xu-Long Wang, Hongsheng Wang, Sarah Kate Lane-Reticker, Elisabeth A. Marnik
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 208-221 (2017)
Summary Interleukin 21 (IL-21) plays key roles in humoral immunity and autoimmune diseases. It is known to function in mature CD4 + T follicular B cell helper (T FH ) cells, but its potential involvement in early T cell ontogeny is unclear. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3180cb33356a1e5d7476f60bbcd1b2b9
http://www.sciencedirect.com/science/article/pii/S2211124717313116
http://www.sciencedirect.com/science/article/pii/S2211124717313116
Autor:
Kathleen B. Yates, Hans W. Pope, Animesh Mahapatra, Kyle M. Ockerman, Emily Kessler, Margaret D. Zimmer, W. Nicholas Haining, Juan Dubrot, Gargi Mishra, Sarah Kate Lane-Reticker, Arvin Iracheta-Vellve, John G. Doench, Austin Ayer, Ian C. Kohnle, Peter P. Du, Clara Wolfe, Thomas Davis, Robert T. Manguso, Peter M. Allen, Kira E Olander
Publikováno v:
Immunity. 54:571-585.e6
Summary CRISPR-Cas9 genome engineering has increased the pace of discovery for immunology and cancer biology, revealing potential therapeutic targets and providing insight into mechanisms underlying resistance to immunotherapy. However, endogenous im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b93fe40b90f5160b8895a8452b9ec6
https://doi.org/10.1016/j.immuni.2021.01.001
https://doi.org/10.1016/j.immuni.2021.01.001
Autor:
Animesh Mahapatra, Sarah Kate Lane-Reticker, Emily Kessler, Peter P. Du, Robert T. Manguso, Clara Wolfe, Juan Dubrot
Publikováno v:
Cancer Research. 80:5866-5866
The ability to make rapid genetic alterations to tumor cells with CRISPR for screens and single-gene studies has been transformative for studying cancer biology. Recently, we and others have used CRISPR in murine tumor models in vivo to identify targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e41c9f60c7d7319b7c9ab3e6da55de7d
https://doi.org/10.1158/1538-7445.am2020-5866
https://doi.org/10.1158/1538-7445.am2020-5866
Autor:
Sarah Kate Lane-Reticker, Austin Ayer, Robert T. Manguso, Juan Dubrot, Animesh Mahapatra, Clara Wolfe, Emily Kessler
Publikováno v:
Cancer Immunology Research. 8:B10-B10
During the last decade, there has been notable progress in cancer immunotherapy, including promising clinical success of immune checkpoint inhibitors. Moreover, there is an increasing number of new potential targets for cancer immunotherapy that are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0003ad3ee58a3bc00b02b4d24645fa5
https://doi.org/10.1158/2326-6074.tumimm19-b10
https://doi.org/10.1158/2326-6074.tumimm19-b10
Publikováno v:
Immunotherapy. 10(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e46ffabab9981c45d372bf8eabd5ac
https://pubmed.ncbi.nlm.nih.gov/29370725
https://pubmed.ncbi.nlm.nih.gov/29370725
Autor:
Elisabeth Adkins, Xulong Wang, Thomas Sproule, Gregory Christianson, Giljun Park, Sarah Kate Lane-Reticker, Gregory Carter, Herbert Morse, Derry Roopenian
Publikováno v:
The Journal of Immunology. 194:201.6-201.6
T follicular helper cells (TFH) are a specific subset of activated CD4+ T cells that localize to germinal centers (GC) and secrete Interleukin 21 (IL21). IL21 is vital for driving the proliferation of antigen-stimulated B cells within GC and their di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ef63be23c76dd3255ea1bd1bfff3f18
https://doi.org/10.4049/jimmunol.194.supp.201.6
https://doi.org/10.4049/jimmunol.194.supp.201.6