Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sarah K. Whiteside"'
Autor:
Colin Y. C. Lee, Bethany C. Kennedy, Nathan Richoz, Isaac Dean, Zewen K. Tuong, Fabrina Gaspal, Zhi Li, Claire Willis, Tetsuo Hasegawa, Sarah K. Whiteside, David A. Posner, Gianluca Carlesso, Scott A. Hammond, Simon J. Dovedi, Rahul Roychoudhuri, David R. Withers, Menna R. Clatworthy
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Tumour dendritic cells (DCs) internalise antigen and upregulate CCR7, which directs their migration to tumour-draining lymph nodes (dLN). CCR7 expression is coupled to an activation programme enriched in regulatory molecule expression, inclu
Externí odkaz:
https://doaj.org/article/a9dead2996844a5bb3e43c7e6aa7f935
Autor:
Charlotte J. Imianowski, Sarah K. Whiteside, Teresa Lozano, Alexander C. Evans, Jayme D. Benson, Christina J.F. Courreges, Firas Sadiyah, Colleen M. Lau, Nordin D. Zandhuis, Francis M. Grant, Martijn J. Schuijs, Panagiota Vardaka, Paula Kuo, Elizabeth J. Soilleux, Jie Yang, Joseph C. Sun, Tomohiro Kurosaki, Klaus Okkenhaug, Timotheus Y.F. Halim, Rahul Roychoudhuri
Publikováno v:
Journal of Experimental Medicine. 219
Natural killer (NK) cells are critical to immune surveillance against infections and cancer. Their role in immune surveillance requires that NK cells are present within tissues in a quiescent state. Mechanisms by which NK cells remain quiescent in ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fecacc7251e7923f5e10f96d7c256dc8
https://doi.org/10.1084/jem.20211476
https://doi.org/10.1084/jem.20211476
Autor:
Sarah K. Whiteside, Jie Yang, Frank Tacke, Alberto G. Conti, Charlotte J. Imianowski, Robert L. Eil, James Dooley, Adrian Liston, Rabab Nasrallah, Rahul Roychoudhuri, Francis M. Grant, Firas Sadiyah, Paula Kuo, Oliver T. Burton, Klaus Okkenhaug, David Gyori, Sergio A. Lira
Publikováno v:
Immunology
CD4+ regulatory T (Treg) cells, dependent upon the transcription factor Foxp3, contribute to tumour immunosuppression but are also required for immune homeostasis. There is interest in developing therapies that selectively target the immunosuppressiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::538d1eef7cebe9fab821852fbfaf9fc1
http://europepmc.org/articles/PMC8274197
http://europepmc.org/articles/PMC8274197
Autor:
Rabab Nasrallah, Dafni A. Glinos, Adrian Liston, Lindsey Placek, Howard Y. Chang, Enrico Lugli, Sarah K. Whiteside, Teresa Lozano, Toshitsugu Fujita, Lina Kozhaya, Francis M. Grant, Rahul Roychoudhuri, Mikail Dogan, Maxwell R. Mumbach, Jie Yang, Charlotte J. Imianowski, Suman Mitra, Gosia Trynka, Derya Unutmaz, Hodaka Fujii, Panagiota Vardaka, Paula Kuo, Lara Bossini-Castillo, Firas Sadiyah, Carly E. Whyte, Adeline Cozzani, Simon Andrews
Publikováno v:
Nature. 583:447-452
Genetic variations underlying susceptibility to complex autoimmune and allergic diseases are concentrated within noncoding regulatory elements termed enhancers1. The functions of a large majority of disease-associated enhancers are unknown, in part o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::985aaa5ed38002ce4d7c1c653f380fea
https://doi.org/10.1038/s41586-020-2296-7
https://doi.org/10.1038/s41586-020-2296-7
Publikováno v:
Trends in Immunology. 39:1021-1035
T cell responses are essential for appropriate protection against pathogens. T cell immunity is achieved through the ability to discriminate between foreign and self-molecules, and this relies heavily on stringent T cell receptor (TCR) specificity. R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1a892beaa8cf963259cdf37543d2bdb
https://doi.org/10.1016/j.it.2018.10.003
https://doi.org/10.1016/j.it.2018.10.003
Autor:
Charlotte J. Imianowski, Rahul Roychoudhuri, Jie Yang, Christopher Bot, Paula Kuo, Teresa Lozano, Simon Walker, Klaus Okkenhaug, Hanneke Okkenhaug, Panagiota Vardaka, Jonathan Ellery, Stuart Farrow, Sarah K. Whiteside
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Whereas effector CD4+ and CD8+ T cells promote immune activation and can drive clearance of infections and cancer, CD4+ regulatory T (Treg) cells suppress their function, contributing to both immune homeostasis and cancer immunosuppression. The trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8fa0432d6df1cb2b7d23dee721a1b46
https://www.repository.cam.ac.uk/handle/1810/312383
https://www.repository.cam.ac.uk/handle/1810/312383
IL-10 Deficiency Reveals a Role for TLR2-Dependent Bystander Activation of T Cells in Lyme Arthritis
Autor:
Janis J. Weis, June L. Round, Matthew A. Williams, James F. Zachary, Colleen Fisher, F. Lynn Sonderegger, Charisse Petersen, Jeremy P. Snook, Ying Ma, Sarah K. Whiteside
Publikováno v:
The Journal of Immunology. 200:1457-1470
T cells predominate the immune responses in the synovial fluid of patients with persistent Lyme arthritis; however, their role in Lyme disease remains poorly defined. Using a murine model of persistent Lyme arthritis, we observed that bystander activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b52a78a0de46b379d8e0364b3d4ba18
https://doi.org/10.4049/jimmunol.1701248
https://doi.org/10.4049/jimmunol.1701248
Autor:
Tomohiro Kurosaki, Kohei Kometani, Ilinca Patrascan, Panagiota Vardaka, Firas Sadiyah, Klaus Okkenhaug, James Clarke, Sarah K. Whiteside, Francis M. Grant, Charlotte J. Imianowski, Nordin Zandhuis, David F. Tough, Robert L. Eil, Rabab Nasrallah, Paula Kuo, Jie Yang, Tihomir Todorov, Rahul Roychoudhuri
Publikováno v:
The Journal of Experimental Medicine
BACH2 is repurposed following Treg lineage commitment to promote the functional quiescence and long-term maintenance of rTreg cells by restraining TCR-driven aTreg differentiation programs. This function is required for immune homeostasis and durable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bab2851659872fd106cdd8fb1b137295
https://pubmed.ncbi.nlm.nih.gov/32515782
https://pubmed.ncbi.nlm.nih.gov/32515782
Autor:
Rabab, Nasrallah, Charlotte J, Imianowski, Lara, Bossini-Castillo, Francis M, Grant, Mikail, Dogan, Lindsey, Placek, Lina, Kozhaya, Paula, Kuo, Firas, Sadiyah, Sarah K, Whiteside, Maxwell R, Mumbach, Dafni, Glinos, Panagiota, Vardaka, Carly E, Whyte, Teresa, Lozano, Toshitsugu, Fujita, Hodaka, Fujii, Adrian, Liston, Simon, Andrews, Adeline, Cozzani, Jie, Yang, Suman, Mitra, Enrico, Lugli, Howard Y, Chang, Derya, Unutmaz, Gosia, Trynka, Rahul, Roychoudhuri
Publikováno v:
Nature. 583(7816)
Genetic variations underlying susceptibility to complex autoimmune and allergic diseases are concentrated within noncoding regulatory elements termed enhancers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4d2650aa8f217a8b6c729c837cf3670
https://pubmed.ncbi.nlm.nih.gov/32769174
https://pubmed.ncbi.nlm.nih.gov/32769174