Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Sarah K. Bergren"'
Autor:
Maher Hanoun, Anna Arnal-Estapé, Maria Maryanovich, Ali H. Zahalka, Sarah K. Bergren, Chee W. Chua, Avigdor Leftin, Patrik N. Brodin, Michael M. Shen, Chandan Guha, Paul S. Frenette
Publikováno v:
Stem Cell Reports, Vol 12, Iss 6, Pp 1201-1211 (2019)
Summary: In the prostate, stem and progenitor cell regenerative capacities have been ascribed to both basal and luminal epithelial cells. Here, we show that a rare subset of mesenchymal cells in the prostate are epithelial-primed Nestin-expressing ce
Externí odkaz:
https://doaj.org/article/15df5a89ccbf40da95f5ba68658f136d
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
The identification of master regulator genes that may be manipulatedin vitro to regulate reprogramming has been difficult. Here, the authors use a computational systems approach to identify three genes (FoxA1, Nkx3.1and the androgen receptor) that ca
Externí odkaz:
https://doaj.org/article/0e59c496500743b6be34bd70195b16c2
Publikováno v:
Cell Reports, Vol 8, Iss 5, Pp 1339-1346 (2014)
The identification of cell types of origin for cancer has important implications for tumor stratification and personalized treatment. For prostate cancer, the cell of origin has been intensively studied, but it has remained unclear whether basal or l
Externí odkaz:
https://doaj.org/article/a54ab0f34ea84a8e8a619681676eab38
NKX3.1 is the most commonly deleted gene in prostate cancer and is a gatekeeper suppressor. NKX3.1 is haploinsufficient, and pathogenic reduction in protein levels may result from genetic loss, decreased transcription, and increased protein degradati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a4526b8cec63bab2b35357fc6ad39db
https://doi.org/10.1158/0008-5472.c.6512338
https://doi.org/10.1158/0008-5472.c.6512338
Supplementary Tables 1-4: Table 1. Primers for PCR amplification for CRISPR/Cas9 mouse models. Table 2. ssODN oligos. Table 3. Primers for genotyping of mouse mutation. Table 4. Antibodies used for immunofluorescence staining. Supplemental Figures 1-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096388bff4e63e7bbf4c91be2f8b5cad
https://doi.org/10.1158/0008-5472.22426435.v1
https://doi.org/10.1158/0008-5472.22426435.v1
Publikováno v:
Cancer Research. 80:4805-4814
NKX3.1 is the most commonly deleted gene in prostate cancer and is a gatekeeper suppressor. NKX3.1 is haploinsufficient, and pathogenic reduction in protein levels may result from genetic loss, decreased transcription, and increased protein degradati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dff51fde2aa9d944b3192ff5f6a92f8
https://doi.org/10.1158/0008-5472.can-20-1742
https://doi.org/10.1158/0008-5472.can-20-1742
Autor:
Anna Arnal-Estapé, Chee W. Chua, Avigdor Leftin, Patrik Brodin, Ali H. Zahalka, Maher Hanoun, Chandan Guha, Sarah K. Bergren, Maria Maryanovich, Michael M. Shen, Paul S. Frenette
Publikováno v:
Stem Cell Reports, Vol 12, Iss 6, Pp 1201-1211 (2019)
Summary: In the prostate, stem and progenitor cell regenerative capacities have been ascribed to both basal and luminal epithelial cells. Here, we show that a rare subset of mesenchymal cells in the prostate are epithelial-primed Nestin-expressing ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ccbd8eaa4038664ce650edff063e38b
https://doi.org/10.1016/j.stemcr.2019.04.019
https://doi.org/10.1016/j.stemcr.2019.04.019
Autor:
Cai, Bowen, Maho, Shibata, Hailan, Zhang, Sarah K, Bergren, Michael M, Shen, Edward P, Gelmann
Publikováno v:
Cancer Res
NKX3.1 is the most commonly deleted gene in prostate cancer and is a gatekeeper suppressor. NKX3.1 is haploinsufficient, and pathogenic reduction in protein levels may result from genetic loss, decreased transcription, and increased protein degradati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eb44db3da362a5453541bd6054d9a780
https://pubmed.ncbi.nlm.nih.gov/32943441
https://pubmed.ncbi.nlm.nih.gov/32943441
Autor:
Maher, Hanoun, Anna, Arnal-Estapé, Maria, Maryanovich, Ali H, Zahalka, Sarah K, Bergren, Chee W, Chua, Avigdor, Leftin, Patrik N, Brodin, Michael M, Shen, Chandan, Guha, Paul S, Frenette
Publikováno v:
Stem cell reports. 12(6)
In the prostate, stem and progenitor cell regenerative capacities have been ascribed to both basal and luminal epithelial cells. Here, we show that a rare subset of mesenchymal cells in the prostate are epithelial-primed Nestin-expressing cells (EPNE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d72bdbcd4f2e797e1789c98211dd72fe
https://pubmed.ncbi.nlm.nih.gov/31130357
https://pubmed.ncbi.nlm.nih.gov/31130357
Autor:
Michael M. Shen, Hanina Hibshoosh, Antonina Mitrofanova, Bo I. Li, Chee Wai Chua, Eva Leung, Nusrat J. Epsi, Ming Lei, Sarah K. Bergren, Shouhong Xuan
Publikováno v:
eLife, Vol 7 (2018)
eLife
eLife
Master regulatory genes of tissue specification play key roles in stem/progenitor cells and are often important in cancer. In the prostate, androgen receptor (AR) is a master regulator essential for development and tumorigenesis, but its specific fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b4d174d7c670a8cfae496ba94ddfe92
https://elifesciences.org/articles/28768
https://elifesciences.org/articles/28768