A Toxoplasma gondii patatin-like phospholipase contributes to host cell invasion.

Autor: Sarah K Wilson, Justine Heckendorn, Bruno Martorelli Di Genova, Lindsey L Koch, Peggy J Rooney, Naomi Morrissette, Maryse Lebrun, Laura J Knoll

Publikováno v: PLoS Pathogens, Vol 16, Iss 7, p e1008650 (2020)

Toxoplasma gondii is an obligate intracellular parasite that can invade any nucleated cell of any warm-blooded animal. In a previous screen to identify virulence determinants, disruption of gene TgME49_305140 generated a T. gondii mutant that could n

Externí odkaz: https://doaj.org/article/5169075d6e3d4e24bb076850e4da42df

A Toxoplasma gondii lipoxygenase-like enzyme is necessary for virulence and changes localization associated with the host immune response

Autor: Carlos J. Ramírez-Flores, Billy Joel Erazo Flores, Andrés M. Tibabuzo Perdomo, Katie L. Barnes, Sarah K. Wilson, Carolina Mendoza Cavazos, Laura J. Knoll

Publikováno v: mBio, Vol 14, Iss 5 (2023)

ABSTRACT While the asexual cycle of Toxoplasma gondii can occur in any warm-blooded animal, the sexual cycle is restricted to the feline intestine. We previously determined that because cats lack delta-6-desaturase activity in their intestines, they

Externí odkaz: https://doaj.org/article/1b175483bf4e450d9da5c0750fd26467

A conserved coccidian gene is involved in Toxoplasma sensitivity to the anti-apicomplexan compound, tartrolon E

Autor: Rachel M. Bone Relat, Gregory D. Bowden, Timothy R. Ramadhar, Roberta M. O'Connor, Patricia M. Reis, Jon Clardy, Maxwell B. Rogers, Sarah K. Wilson, Bruno Martorelli Di Genova, Kelly A. Brayton, Laura J. Knoll, Albert K. Tai, Felix J.V. Nepveux

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 14, Iss, Pp 1-7 (2020)
International Journal for Parasitology: Drugs and Drug Resistance

New treatments for the diseases caused by apicomplexans are needed. Recently, we determined that tartrolon E (trtE), a secondary metabolite derived from a shipworm symbiotic bacterium, has broad-spectrum anti-apicomplexan parasite activity. TrtE inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e75d3539d1d779ee3bce6c69ad909e
https://doi.org/10.1016/j.ijpddr.2020.07.003

Patatin-like phospholipases in microbial infections with emerging roles in fatty acid metabolism and immune regulation by Apicomplexa

Autor: Laura J. Knoll, Sarah K. Wilson

Publikováno v: Molecular Microbiology. 107:34-46

Summary Emerging lipidomic technologies have enabled researchers to dissect the complex roles of phospholipases in lipid metabolism, cellular signaling, and immune regulation. Host phospholipase products are involved in stimulating and resolving the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1334c4c04faff8ed6e49253e9e4f3a8
https://doi.org/10.1111/mmi.13871

PROPOFOL AS AN IMMERSION ANESTHETIC AND IN A MINIMUM ANESTHETIC CONCENTRATION (MAC) REDUCTION MODEL IN GOLDFISH (CARASSIUS AURATUS)

Autor: Julie A. Balko, Brian Gaines, Gregory A. Lewbart, Sarah K. Wilson, Lysa P. Posner

Publikováno v: Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 48(1)

Propofol is a novel immersion anesthetic in goldfish ( Carassius auratus ). Objectives were to characterize propofol as an anesthetic and assess its suitability in a minimum anesthetic concentration (MAC) reduction model. Using a crossover design, ei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512888ac7df2392a1ab0955c9f28e705
https://pubmed.ncbi.nlm.nih.gov/28363074