Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Sarah K Williams"'
Autor:
Mayur Dembla, Ajay Kesharwani, Sivaraman Natarajan, Claudia Fecher‐Trost, Richard Fairless, Sarah K Williams, Veit Flockerzi, Ricarda Diem, Karin Schwarz, Frank Schmitz
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 11, Pp n/a-n/a (2018)
Abstract Optic neuritis is one of the first manifestations of multiple sclerosis. Its pathogenesis is incompletely understood, but considered to be initiated by an auto‐immune response directed against myelin sheaths of the optic nerve. Here, we de
Externí odkaz:
https://doaj.org/article/7372cd2bdb174bcbac029be8963c4d0f
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-9 (2024)
Abstract Motor neuron loss is well recognized in amyotrophic lateral sclerosis (ALS), but research on retinal ganglion cells (RGCs) is limited. Ocular symptoms are generally not considered classic ALS symptoms, although RGCs and spinal motor neurons
Externí odkaz:
https://doaj.org/article/f1c112580f914795a52c0e0dda1d6389
Autor:
Sarah K Williams, Olaf Maier, Roman Fischer, Richard Fairless, Sonja Hochmeister, Aleksandar Stojic, Lara Pick, Doreen Haar, Sylvia Musiol, Maria K Storch, Klaus Pfizenmaier, Ricarda Diem
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90117 (2014)
Tumour necrosis factor (TNF) is a proinflammatory cytokine that is known to regulate inflammation in a number of autoimmune diseases, including multiple sclerosis (MS). Although targeting of TNF in models of MS has been successful, the pathological r
Externí odkaz:
https://doaj.org/article/d22907a816ca48d2a37e88deabdc6de2
Autor:
Richard Fairless, Andreas Beck, Mykola Kravchenko, Sarah K Williams, Ulrich Wissenbach, Ricarda Diem, Adolfo Cavalié
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58260 (2013)
The ability to monitor changes in membrane potential is a useful tool for studying neuronal function, but there are only limited options available at present. Here, we have investigated the potential of a commercially available FLIPR membrane potenti
Externí odkaz:
https://doaj.org/article/97e545e244264e1abaa4f02b706f66a1
Autor:
Chi Wang Ip, Antje Kroner, Janos Groh, Marianne Huber, Dennis Klein, Irene Spahn, Ricarda Diem, Sarah K Williams, Klaus-Armin Nave, Julia M Edgar, Rudolf Martini
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42554 (2012)
Mice overexpressing proteolipid protein (PLP) develop a leukodystrophy-like disease involving cytotoxic, CD8+ T-lymphocytes. Here we show that these cytotoxic T-lymphocytes perturb retrograde axonal transport. Using fluorogold stereotactically inject
Externí odkaz:
https://doaj.org/article/490a226888b44e41905a2f36864d361a
Publikováno v:
Frontiers in Psychiatry, Vol 2 (2011)
Phasic activity of the mesolimbic dopamine pathway – burst firing of dopamine neurons and the resulting dopamine release events at striatal targets – have been associated with a variety of motivational events, such as novelty, salient stimuli, so
Externí odkaz:
https://doaj.org/article/f4c579acb44b4535a2a25852f042f553
Autor:
Timon Fiedler, Richard Fairless, Kira Pichi, Roman Fischer, Fabian Richter, Roland E. Kontermann, Klaus Pfizenmaier, Ricarda Diem, Sarah K. Williams
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-13 (2023)
Abstract Background Tumour necrosis factor (TNF) is a pleiotropic cytokine and master regulator of the immune system. It acts through two receptors resulting in often opposing biological effects, which may explain the lack of therapeutic potential ob
Externí odkaz:
https://doaj.org/article/419220a7d4354d2c8e22cb1683c5790a
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2094 (2023)
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) characterised by acute inflammation and subsequent neuro-axonal degeneration resulting in progressive neurological impairment. Aberrant immune system activati
Externí odkaz:
https://doaj.org/article/554fabe72b7c41289628c2353f05d922
Autor:
Dana Bakalar, Oksana Gavrilova, Sunny Z. Jiang, Hai‐ying Zhang, Snehashis Roy, Sarah K. Williams, Naili Liu, Stephen Wisser, Ted B. Usdin, Lee E. Eiden
Publikováno v:
Journal of Neuroendocrinology.
Autor:
Kwadwo A. Opoku-Nsiah, Andres H. de la Pena, Sarah K. Williams, Nikita Chopra, Andrej Sali, Gabriel C. Lander, Jason E. Gestwicki
Publikováno v:
Nature communications, vol 13, iss 1
The 20S proteasome (20S) facilitates turnover of most eukaryotic proteins. Substrate entry into the 20S first requires opening of gating loops through binding of HbYX motifs that are present at the C-termini of certain proteasome activators (PAs). Th