Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Sarah K Bronson"'
Autor:
Timothy D Riley, Jessica A Parascando, Erika VanDyke, Heather L Stuckey, Huamei Dong, Omrana Pasha-Razzak, Lawrence E Kass, Jennifer McCall-Hosenfeld, Sarah K Bronson
Publikováno v:
Journal of Medical Education and Curricular Development, Vol 11 (2024)
OBJECTIVES Burnout is common among junior faculty. Professional development has been proposed as a method to improve engagement and reduce burnout among academic physicians. The Penn State College of Medicine Junior Faculty Development Program (JFDP)
Externí odkaz:
https://doaj.org/article/755fe6c07398401faf4b7e5c4087a6e7
Autor:
Heather D VanGuilder, Georgina V Bixler, Lydia Kutzler, Robert M Brucklacher, Sarah K Bronson, Scot R Kimball, Willard M Freeman
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16271 (2011)
BACKGROUND: As a leading cause of adult blindness, diabetic retinopathy is a prevalent and profound complication of diabetes. We have previously reported duration-dependent changes in retinal vascular permeability, apoptosis, and mRNA expression with
Externí odkaz:
https://doaj.org/article/21068942c8e34a8f8a9a343ee2866307
Autor:
Ting Gao, Hanning You, Timothy K. Cooper, W. Brian Reeves, Wesley M. Raup-Konsavage, Sarah K. Bronson, Alaa S. Awad
Publikováno v:
Kidney International. 91:671-682
Inflammation is a central pathophysiologic mechanism that contributes to diabetes mellitus and diabetic nephropathy. Recently, we showed that macrophages directly contribute to diabetic renal injury and that pharmacological blockade or genetic defici
Autor:
John M. Flanagan, Michelle M. Pedersen, Sarah K. Bronson, Robert E. Anderson, Dae Young Jung, Kellee A. Unrath, Todd E. Fox, Mark Kester, Leonard S. Jefferson, Maria C. Bewley, Jason K. Kim
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 3, Pp 509-517 (2011)
Alterations in lipid metabolism may contribute to diabetic complications. Sphingolipids are essential components of cell membranes and have essential roles in homeostasis and in the initiation and progression of disease. However, the role of sphingol
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 298:E1283-E1294
Sepsis and lipopolysaccharide (LPS) may decrease skeletal muscle protein synthesis by impairing mTOR (mammalian target of rapamycin) activity. The role of mTOR in regulating muscle protein synthesis was assessed in wild-type (WT) and mTOR heterozygou
Publikováno v:
Journal of Cellular Biochemistry. 109:643-652
Induced pluripotent stem cells (iPSCs) have generated hope and excitement because of the potential they possess for generating patient-specific embryonic-like stem cells (ESCs). Although many hurdles remain to be solved before the cells can be applie
Autor:
Alistair J. Barber, Heather D. VanGuilder, Thomas W. Gardner, Kruti M. Patel, Robert M. Brucklacher, Sarah K. Bronson, Kathryn F. LaNoue, Scot R. Kimball, Willard M. Freeman, Cheng-mao Lin, David A. Antonetti, Georgina V. Bixler
Publikováno v:
The Pharmacogenomics Journal. 10:385-395
Biomarkers that can be measured in preclinical models in a high-throughput, reproducible manner offer the potential to increase the speed and efficacy of drug development. Development of therapeutic agents for many conditions is hampered by the limit
Autor:
Erin Walsh, Scot R. Kimball, Sarah K. Bronson, Georgina V. Bixler, Robert M. Brucklacher, Willard M. Freeman, Leonard S. Jefferson
Publikováno v:
Journal of Ocular Biology, Diseases, and Informatics
Mouse models of type I diabetes offer the potential to combine genetic approaches with other pharmacological or physiological manipulations to investigate the pathophysiology and treatment of diabetic retinopathy. Type I diabetes is induced in mice t
Publikováno v:
Stem Cells and Development. 15:865-879
The process of bone formation can be approximated in vitro in the form of a mineralized nodule. Osteoprogenitors and mesenchymal stem cells (MSCs), the immediate precursors of the osteoprogenitor, proliferate and differentiate into osteoblasts when p
Autor:
Scot R. Kimball, Alistair J. Barber, Ian A. Simpson, Willard M. Freeman, David A. Antonetti, Leonard S. Jefferson, Lakshman Sandirasegarane, Sarah K. Bronson, Mark Kester, J. Kyle Krady, Thomas W. Gardner, Christopher C. Norbury, Patrick G. Quinn, Kathryn F. LaNoue
Publikováno v:
Diabetes. 55:2401-2411
Diabetic retinopathy remains a frightening prospect to patients and frustrates physicians. Destruction of damaged retina by photocoagulation remains the primary treatment nearly 50 years after its introduction. The diabetes pandemic requires new appr