Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sarah Johannes"'
Autor:
Hannah JÖRIßEN, Beatrix Stelte-Ludwig, Lisa Dietz, Simone Greven, Anette Sommer, Sarah Johannes, Anne-Sophie Rebstock, Hans-Georg Lerchen, Christoph Mahlert, Sandra Berndt
Publikováno v:
Bioconjugate Chemistry. 31:1893-1898
Several antibody-drug conjugates (ADCs) have failed to achieve a sufficiently large therapeutic window in patients due to toxicity induced by unspecific payload release in the circulation or ADC uptake into healthy organs. Herein, we describe the suc
Autor:
Christoph Mahlert, Beatrix Stelte-Ludwig, Sarah Johannes, Lisa Dietz, Hannah JÖRIßEN, Hans-Georg Lerchen, Anette Sommer, Anne-Sophie Rebstock, Simone Greven, Leo Marx, Sandra Berndt
Publikováno v:
Chemistry – A European Journal. 25:8208-8213
Many antibody-drug conjugates (ADCs) have failed to achieve a sufficient therapeutic window in clinical studies either due to target-mediated or off-target toxicities. To achieve an additional safety level, a new class of antibody-prodrug conjugates
Autor:
Sven Wittrock, Carsten Terjung, Anne-Sophie Rebstock, Nils Griebenow, Anette Sommer, Beatrix Stelte-Ludwig, Hans-Georg Lerchen, Yolanda Cancho-Grande, Christoph Mahlert, Sarah Johannes, Sandra Berndt, Simone Greven
Publikováno v:
Angewandte Chemie International Edition. 57:15243-15247
The number of cytotoxic payload classes successfully employed in antibody-drug conjugates (ADCs) is still rather limited. The identification of ADC payloads with a novel mode of action will increase therapeutic options and potentially increase the th
Autor:
Martin Lange, Erik Schulz, Mario Huerta, Mona Blatter, Ali Nowrouzi, Bernhard Kuster, Ulrike Uhrig, Karin Laaber, Axel Benner, Hanno Glimm, Claudia R. Ball, Sina Kreth, Dominik Mumberg, Kerstin Putzker, Friederike Herbst, Joerg Weiske, Hannes Hahne, Sarah Johannes, Gerhard Siemeister, Frank Westermann, Andrea Haegebarth, Martina K. Zowada, Gabriele Stoehr, Simon Holton, Paula L Codo, Joe Lewis, Sebastian M. Dieter, Ulrike Scheib, Lena-Marit Toepper, Sylvia Martin, Christine Siegl, Anna L. Ostermann-Parucha
Summary Novel treatment options for metastatic colorectal cancer (CRC) are urgently needed to improve patient outcome. Here, we screen a library of non-characterized small molecules against a heterogeneous collection of patient-derived CRC spheroids.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a410f992a87b35fec1505c6f97a79632
https://mediatum.ub.tum.de/doc/1652086/document.pdf
https://mediatum.ub.tum.de/doc/1652086/document.pdf
Autor:
Dennis Kirchhoff, Sandra Johanssen, Pascale Lejeune, Hannah JÖRIßEN, Stephan Märsch, Christoph Mahlert, Sarah Johannes, Sandra Berndt, Hans-Georg Lerchen, Beatrix Stelte-Ludwig, Leo Marx, Anette Sommer, Lisa Dietz, Ruprecht Zierz, Anne-Sophie Rebstock, Sven Wittrock, Simone Greven
Publikováno v:
ADC Review / Journal of Antibody-drug Conjugates.
With the approval of meanwhile five ADCs and more than 80 ADCs in clinical trials, the ADC landscape has developed rapidly during the last decade. However, as indicated also by the large number of ADCs which failed in the clinic, it remains challengi
Autor:
Hans-Georg Lerchen, Hilmar Weinmann, Anne-Sophie Rebstock, Hannah Joerissen, Sandra Berndt, Lisa Dietz, Leo Marx, Anette Sommer, Beatrix Stelte-Ludwig, Sarah Johannes, Christoph Mahlert, Simone Greven
Publikováno v:
Cancer Research. 79:228-228
Inhibitors of kinesin spindle protein (KSP/Eg5) have raised great interest because of their high antitumor potency which, however, could not be transferred into highly efficient clinical regimens due to dose limiting side effects such as neutropenia.
Autor:
Sarah Johannes, Stefanie Hammer, Stephan Maersch, Hans-Georg Lerchen, Beatrix Stelte-Ludwig, Hannah Joerissen, Oliver von Ahsen, Christoph Schatz, Simone Greven, Christoph Mahlert, Dominik Mumberg, Pascale Lejeune
Publikováno v:
Cancer Research. 79:4825-4825
Despite recent progress in the treatment of B-cell malignancies, patients are still in need of innovative therapeutic approaches. CXCR5 is a chemokine receptor expressed in a majority of B-cell malignancies including diffuse large B-cell lymphoma (DL
Autor:
Lisa Dietz, Anne-Sophie Rebstock, Anette Sommer, Leo Marx, Simone Greven, Sandra Berndt, Christoph Mahlert, Beatrix Stelte-Ludwig, Hans-Georg Lerchen, Sarah Johannes, Hannah JÖRIßEN
Publikováno v:
Chemistry – A European Journal. 25:8171-8171
Autor:
Anette Sommer, Carsten Terjung, Yolanda Cancho-Grande, Beatrix Stelte-Ludwig, Anne-Sophie Rebstock, Sven Wittrock, Christoph Mahlert, Hans-Georg Lerchen, Sarah Johannes, Simone Greven, Nils Griebenow, Sandra Berndt
Publikováno v:
Angewandte Chemie International Edition. 57:14950-14950
Autor:
Carol Brokos, Deborah L. Schofield, Gloria Moses, Sarah Johannes, Renee Gruel, Patricia Gonce Morton, Nancy McBride
Publikováno v:
Bariatric Nursing and Surgical Patient Care. 6:201-206
Obesity has risen to epidemic proportions in the United States and is increasing among all populations. The complications associated with obesity have a tremendous impact on healthcare and hospital costs. The diagnosis of obesity alone is believed to