The human CIB1–EVER1–EVER2 complex governs keratinocyte-intrinsic immunity to β-papillomaviruses

Autor: Matthieu Bouaziz, Sirous Zeinali, Vignesh Gunasekharan, Fabienne Jabot-Hanin, Sarah Jill De Jong, Peter Itin, Nessa Aghazadeh, Xavier Rueda Cadena, E. Imahorn, Aurelia D’Amico, Amandine Crequer, Irina Matos, Elaine Fuchs, Bettina Burger, Janet Markle, David Hum, Etienne Patin, Florian Full, Bayaki Saka, Amir Hossein Saeidian, Laurent Abel, James G. Krueger, Nataly Portilla Maya, Claire Q.F. Wang, Jouni Uitto, Emmanuelle Jouanguy, Leila Youssefian, Hassan Vahidnezhad, Armin Ensser, Andrés Augusto Arias, Leslie V. Parise, Tina M. Leisner, Jean-Laurent Casanova, Lou Laimins, Lazaro Lorenzo, Gérard Orth, José Luis Franco

Publikováno v: Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2018, 215 (9), pp.2289-2310. ⟨10.1084/jem.20170308⟩
Journal of Experimental Medicine, 2018, 215 (9), pp.2289-2310. ⟨10.1084/jem.20170308⟩

International audience; Patients with epidermodysplasia verruciformis (EV) and biallelic null mutations of TMC6 (encoding EVER1) or TMC8 (EVER2) are selectively prone to disseminated skin lesions due to keratinocyte-tropic human β-papillomaviruses (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f84fccd94dce744d9f8af1b6a12c3a2
https://doi.org/10.1084/jem.20170308

Homozygous NLRP1 gain-of-function mutation in siblings with a syndromic form of recurrent respiratory papillomatosis

Autor: Sarah Jill De Jong, Sofie De Schepper, Jean-Laurent Casanova, Jutte van der Werff ten Bosch, David Hum, Emmanuelle Jouanguy, Franklin L. Zhong, Vincent R. Bonagura, Scott Drutman, Nicholas Hernandez, David Creytens, Gérard Orth, Katrien Bonte, Andy Wullaert, Franck Rapaport, Filomeen Haerynck, Laurent Abel, Serkan Belkaya, Xavier Bossuyt, Vivien Béziat, Lazaro Lorenzo-Diaz, Bruno Reversade, Simon Tavernier

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 116(38), 19055-19063. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America

Juvenile-onset recurrent respiratory papillomatosis (JRRP) is a rare and debilitating childhood disease that presents with recurrent growth of papillomas in the upper airway. Two common human papillomaviruses (HPVs), HPV-6 and -11, are implicated in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ccc719080bb3cc3a6a38e5db3e92583
https://pure.amc.nl/en/publications/homozygous-nlrp1-gainoffunction-mutation-in-siblings-with-a-syndromic-form-of-recurrent-respiratory-papillomatosis(16988276-9a9b-4487-b87c-baf543687e04).html

Transduction of Herpesvirus saimiri-Transformed T Cells with Exogenous Genes of Interest

Autor: Bernhard Fleckenstein, Janet Markle, Rubén Martínez-Barricarte, Roel de Paus, Stéphanie Boisson-Dupuis, Esther van de Vosse, Jacinta Bustamante, Jean-Laurent Casanova, Sarah Jill De Jong

Publikováno v: Current Protocols in Immunology

Human T cells can be transformed and expanded with herpesvirus saimiri (HVS). HVS-transformed T cells from patients have facilitated the study of a broad range of primary immunodeficiencies (PID) in which T-cell development or function is altered. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02205044b5aa2015571fcc9e5d13ffc6
https://pubmed.ncbi.nlm.nih.gov/27801513

Noncanonical NF-κB Activation by the Oncoprotein Tio Occurs Through a Nonconserved TRAF3-Binding Motif

Autor: Heinrich Sticht, Brigitte Biesinger, Sarah Jill de Jong, Jens-Christian Albrecht, Fabian Giehler, Arnd Kieser

Publikováno v: Science Signaling. 6

Members of the nuclear factor κB (NF-κB) family of transcription factors regulate many cellular functions. Activation of NF-κB signaling is commonly classified as occurring through canonical or noncanonical pathways. Most NF-κB-inducing stimuli,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b0c870c78aafc990d38c0aee3b024d
https://doi.org/10.1126/scisignal.2003309

Species restriction of Herpesvirus saimiri and Herpesvirus ateles: human lymphocyte transformation correlates with distinct signaling properties of viral oncoproteins

Autor: Kristin Katsch, Brigitte Biesinger, Monika Schmidt, Sarah Jill de Jong, Bernhard Fleckenstein, Ingrid Müller-Fleckenstein, Jens-Christian Albrecht

Publikováno v: Virus research. 165(2)

The potential of Herpesvirus saimiri (HVS) subgroups A, B and C and Herpesvirus ateles (HVA) to transform primary T cells to permanent growth in vitro is restricted by the primate host species and by viral variability represented by distinct viral on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::897e24296b6d7c55ca1cda20b00c8822
https://pubmed.ncbi.nlm.nih.gov/22374337