Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production

Autor: Céline Zimmer, Magali Macchi, Kay Grobe, Anna Williams, Elitsa Peeva, Pascale Durbec, Bilal El Waly, Friedemann Kiefer, Myriam Cayre, Béatrice Brousse, Sarah Jaekel, Karine Magalon

Publikováno v: eLife
eLife, 2020, 9, ⟨10.7554/eLife.51735⟩
eLife, Vol 9 (2020)
eLife, eLife Sciences Publication, 2020, 9, ⟨10.7554/eLife.51735⟩
Macchi, M, Magalon, K, Zimmer, C, Peeva, E, El Waly, B, Brousse, B, Jaekel, S, Grobe, K, Kiefer, F, Williams, A C, Cayre, M & Durbec, P 2020, ' Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulphate production ', eLIFE . https://doi.org/10.7554/eLife.51735
Macchi, M, Magalon, K, Zimmer, C, Peeva, E, El Waly, B, Brousse, B, Jaekel, S, Grobe, K, Kiefer, F, Williams, A, Cayre, M & Durbec, P 2020, ' Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production ', eLIFE, vol. 9, e51735 . https://doi.org/10.7554/eLife.51735

International audience; Myelin destruction is followed by resident glia activation and mobilization of endogenous progenitors (OPC) which participate in myelin repair. Here we show that in response to demyelination, mature oligodendrocytes (OLG) bord

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https://hal.science/hal-02993047/document