Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sarah J. Texel"'
Autor:
Sarah J Texel, Jian Zhang, Simonetta Camandola, Erica L Unger, Dennis D Taub, Raymond C Koehler, Z Leah Harris, Mark P Mattson
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25077 (2011)
Ceruloplasmin (Cp) is an essential ferroxidase that plays important roles in cellular iron trafficking. Previous findings suggest that the proper regulation and subcellular localization of iron are very important in brain cell function and viability.
Externí odkaz:
https://doaj.org/article/437b16f2fd614508895b370e41589417
Autor:
Sarah M. Rothman, Simonetta Camandola, Bruce Ladenheim, Sarah J. Texel, Mohamed R. Mughal, Mark P. Mattson, Erica L. Unger, Jean Lud Cadet
Publikováno v:
Journal of Neurochemistry. 120:125-134
J. Neurochem. (2012) 120, 125–134. Abstract Ceruloplasmin (Cp) is a ferroxidase involved in iron metabolism by converting Fe2+ to Fe3+, and by regulating cellular iron efflux. In the ceruloplasmin knockout (CpKO) mouse, the deregulation of iron met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35abb1516c9017ac549fe285a9221eb8
https://doi.org/10.1111/j.1471-4159.2011.07554.x
https://doi.org/10.1111/j.1471-4159.2011.07554.x
Impaired Adaptive Cellular Responses to Oxidative Stress and the Pathogenesis of Alzheimer's Disease
Autor:
Mark P. Mattson, Sarah J. Texel
Publikováno v:
Antioxidants & Redox Signaling. 14:1519-1534
As is generally true with other age-related diseases, Alzheimer's disease (AD) involves oxidative damage to cellular components in the affected tissue, in this case the brain. The causes and consequences of oxidative stress in neurons in AD are not f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e861e1234d46e6a32efdeba255a9b013
https://doi.org/10.1089/ars.2010.3569
https://doi.org/10.1089/ars.2010.3569
Publikováno v:
European Journal of Neuroscience. 24:3381-3386
The arachidonic acid-specific cytosolic phospholipase A(2) alpha (cPLA(2)alpha) has been implicated in the generation of neurological injuries. cPLA(2)alpha-dependent neurological injury has been postulated to be mediated through inflammatory and eic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c25ee2a4307739a57af5fe688cd2f62
https://doi.org/10.1111/j.1460-9568.2006.05237.x
https://doi.org/10.1111/j.1460-9568.2006.05237.x
Autor:
Adam Sapirstein, Tarek A. Samad, Eileen O'Leary, Sarah J. Texel, Joseph V. Bonventre, Hideyuki Saito
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 288:R1774-R1782
The products of arachidonic acid metabolism are key mediators of inflammatory responses in the central nervous system, and yet we do not know the mechanisms of their regulation. The phospholipase A2 enzymes are sources of cellular arachidonic acid, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e33e15f44f1c1742a6bc8c6494bf13e
https://doi.org/10.1152/ajpregu.00815.2004
https://doi.org/10.1152/ajpregu.00815.2004
Publikováno v:
Iron Physiology and Pathophysiology in Humans ISBN: 9781603274845
The cells of the central nervous system, and in particular neurons, are metabolically active cells with a high iron requirement. The mechanism(s) by which iron is trafficked across the blood–brain barrier has yet to be fully elucidated. A great int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fccabd649d596ea19e571fe6e8f8008
https://doi.org/10.1007/978-1-60327-485-2_23
https://doi.org/10.1007/978-1-60327-485-2_23
Autor:
Erica L. Unger, Simonetta Camandola, Mark P. Mattson, Dennis D. Taub, Sarah J. Texel, Z. Leah Harris, Raymond C. Koehler, Jian Zhang
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 9, p e25077 (2011)
PLoS ONE, Vol 6, Iss 9, p e25077 (2011)
Ceruloplasmin (Cp) is an essential ferroxidase that plays important roles in cellular iron trafficking. Previous findings suggest that the proper regulation and subcellular localization of iron are very important in brain cell function and viability.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a89d21feaa227ba7ea61ad51b617c3f7
https://pubmed.ncbi.nlm.nih.gov/21949858
https://pubmed.ncbi.nlm.nih.gov/21949858
Publikováno v:
Biochemical Society transactions. 36(Pt 6)
Two decades ago, patients lacking circulating serum ceruloplasmin (Cp) presented with neurodegeneration associated with brain iron accumulation. These patients, with mutations in the MCO (multi-copper oxidase), Cp, revealed an essential role for Cp i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5abfd8090397353b045ba007efc3d8d4
https://pubmed.ncbi.nlm.nih.gov/19021540
https://pubmed.ncbi.nlm.nih.gov/19021540
Publikováno v:
The European journal of neuroscience. 24(12)
The arachidonic acid-specific cytosolic phospholipase A(2) alpha (cPLA(2)alpha) has been implicated in the generation of neurological injuries. cPLA(2)alpha-dependent neurological injury has been postulated to be mediated through inflammatory and eic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ab9d78af22ff6ab7fe7e5df548f9cd9e
https://pubmed.ncbi.nlm.nih.gov/17229087
https://pubmed.ncbi.nlm.nih.gov/17229087
Autor:
Mohamed R. Mughal, Wei Na Cong, Sarah J. Texel, Mark P. Mattson, Nathan Herdener, Simonetta Camandola, Sarah M. Rothman, Bronwen Martin
Publikováno v:
Neurobiology of Aging. 33:830.e1-830.e12
Chronic stress may be a risk factor for developing Alzheimer's disease (AD), but most studies of the effects of stress in models of AD utilize acute adverse stressors of questionable clinical relevance. The goal of this work was to determine how chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0241f1fd23c10e5960a21371b9d6ec8
https://doi.org/10.1016/j.neurobiolaging.2011.07.005
https://doi.org/10.1016/j.neurobiolaging.2011.07.005