Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Sarah J. Ross"'
Publikováno v:
The Biochemical journal
Approximately 15% of all cancer patients harbor mutated KRAS. Direct inhibitors of KRAS have now been generated and are beginning to make progress through clinical trials. These include a suite of inhibitors targeting the KRASG12C mutation commonly f
Autor:
Jesse Boumelha, Sophie de Carné Trécesson, Emily K. Law, Pablo Romero-Clavijo, Matthew A. Coelho, Kevin W. Ng, Edurne Mugarza, Christopher Moore, Sareena Rana, Deborah R. Caswell, Miguel Murillo, David C. Hancock, Prokopios P. Argyris, William L. Brown, Cameron Durfee, Lindsay K. Larson, Rachel I. Vogel, Alejandro Suárez-Bonnet, Simon L. Priestnall, Philip East, Sarah J. Ross, George Kassiotis, Miriam Molina-Arcas, Charles Swanton, Reuben Harris, Julian Downward
Publikováno v:
Cancer Res
Mutations in oncogenes such as KRAS and EGFR cause a high proportion of lung cancers. Drugs targeting these proteins cause tumor regression but ultimately fail to elicit cures. As a result, there is an intense interest in how to best combine targeted
Autor:
A. Nigel Brooks, Stephen R. Wedge, Susan E. Critchlow, Craig N. Robson, Simon T. Barry, Chris Womack, Luke Gaughan, Alfred Rabow, Robert H. Bradbury, Rhys D.O. Jones, Joanne Wilson, Marie Cumberbatch, Vivien N. Jacobs, Fadhel S. Shaheen, Elizabeth Mouchet, Dawn Trueman, Natalie C. Stratton, Nicola Broadbent, Sandra R. Brave, Tom P.J. Dunkley, Graeme E. Walker, David M. Robinson, Andrew G. Thomason, Sarah J. Ross, Sarah A. Loddick
PDF - 56KB, Supplementary methods detailing Relative peptide quantification by selected reaction monitoring (SRM)using mass spectrometry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d12f691841ae5003bde43d483fc498
https://doi.org/10.1158/1535-7163.22500958
https://doi.org/10.1158/1535-7163.22500958
Autor:
A. Nigel Brooks, Stephen R. Wedge, Susan E. Critchlow, Craig N. Robson, Simon T. Barry, Chris Womack, Luke Gaughan, Alfred Rabow, Robert H. Bradbury, Rhys D.O. Jones, Joanne Wilson, Marie Cumberbatch, Vivien N. Jacobs, Fadhel S. Shaheen, Elizabeth Mouchet, Dawn Trueman, Natalie C. Stratton, Nicola Broadbent, Sandra R. Brave, Tom P.J. Dunkley, Graeme E. Walker, David M. Robinson, Andrew G. Thomason, Sarah J. Ross, Sarah A. Loddick
PDF - 464KB, Supplementary Figure 1: Inhibition of AR transcripts with AZD3514 treated LNCaPs in steroid free media and the timecourse of AZD3514 effects in the presence and absence of DHT. Supplementary Figure 2: Effect of AZD3514 on growth of AR ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5d194c3a51c866f292b69afd928b73e
https://doi.org/10.1158/1535-7163.22500961
https://doi.org/10.1158/1535-7163.22500961
Autor:
A. Nigel Brooks, Stephen R. Wedge, Susan E. Critchlow, Craig N. Robson, Simon T. Barry, Chris Womack, Luke Gaughan, Alfred Rabow, Robert H. Bradbury, Rhys D.O. Jones, Joanne Wilson, Marie Cumberbatch, Vivien N. Jacobs, Fadhel S. Shaheen, Elizabeth Mouchet, Dawn Trueman, Natalie C. Stratton, Nicola Broadbent, Sandra R. Brave, Tom P.J. Dunkley, Graeme E. Walker, David M. Robinson, Andrew G. Thomason, Sarah J. Ross, Sarah A. Loddick
PDF - 71KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36cd40a1e742de8a4011274fdf37bb1e
https://doi.org/10.1158/1535-7163.22500964.v1
https://doi.org/10.1158/1535-7163.22500964.v1
Autor:
A. Nigel Brooks, Stephen R. Wedge, Susan E. Critchlow, Craig N. Robson, Simon T. Barry, Chris Womack, Luke Gaughan, Alfred Rabow, Robert H. Bradbury, Rhys D.O. Jones, Joanne Wilson, Marie Cumberbatch, Vivien N. Jacobs, Fadhel S. Shaheen, Elizabeth Mouchet, Dawn Trueman, Natalie C. Stratton, Nicola Broadbent, Sandra R. Brave, Tom P.J. Dunkley, Graeme E. Walker, David M. Robinson, Andrew G. Thomason, Sarah J. Ross, Sarah A. Loddick
PDF - 329KB, Supplementary Table 1: TSQ Vantage mass spectrometry instrument settings. Supplementary Table 2: 4000 QTRAP mass spectrometry instrument settings. Supplementary Table 3: The half-life of AR for the first 6 hours following treatment calcu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b48ad0925bc03fcf57e4609a27abf58
https://doi.org/10.1158/1535-7163.22500955
https://doi.org/10.1158/1535-7163.22500955
Autor:
Ian A. Prior, Patrick A. Eyers, Paul D. Smith, Joseph R. Slupsky, Sarah J. Ross, David J. MacEwan, Judy M. Coulson, Fiona E. Hood, Dean E. Hammond, Adam Linley, Leah J. Wilson
The human protein kinome comprises 535 proteins that, with the exception of approximately 50 pseudokinases, control intracellular signaling networks by catalyzing the phosphorylation of multiple protein substrates. While a major research focus of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cd2ef03c897f56937b46b2d011e2a10
https://doi.org/10.1158/0008-5472.c.6509586.v1
https://doi.org/10.1158/0008-5472.c.6509586.v1
Autor:
Ian A. Prior, Patrick A. Eyers, Paul D. Smith, Joseph R. Slupsky, Sarah J. Ross, David J. MacEwan, Judy M. Coulson, Fiona E. Hood, Dean E. Hammond, Adam Linley, Leah J. Wilson
The human protein kinome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a88493265c1f472a5fb2a9698934ca61
https://doi.org/10.1158/0008-5472.22416570.v1
https://doi.org/10.1158/0008-5472.22416570.v1
Autor:
Julian Downward, Reuben Harris, Charles Swanton, Miriam Molina-Arcas, George Kassiotis, Sarah J. Ross, Philip East, Simon L. Priestnall, Alejandro Suárez-Bonnet, Rachel I. Vogel, Lindsay K. Larson, Cameron Durfee, William L. Brown, Prokopios P. Argyris, David C. Hancock, Miguel Murillo, Deborah R. Caswell, Sareena Rana, Christopher Moore, Edurne Mugarza, Kevin W. Ng, Matthew A. Coelho, Pablo Romero-Clavijo, Emily K. Law, Sophie de Carné Trécesson, Jesse Boumelha
Supplementary Data from An Immunogenic Model of KRAS-Mutant Lung Cancer Enables Evaluation of Targeted Therapy and Immunotherapy Combinations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55fc3e20f035a7d1519858bb7c34e1ae
https://doi.org/10.1158/0008-5472.22432362
https://doi.org/10.1158/0008-5472.22432362
Autor:
Julian Downward, Reuben Harris, Charles Swanton, Miriam Molina-Arcas, George Kassiotis, Sarah J. Ross, Philip East, Simon L. Priestnall, Alejandro Suárez-Bonnet, Rachel I. Vogel, Lindsay K. Larson, Cameron Durfee, William L. Brown, Prokopios P. Argyris, David C. Hancock, Miguel Murillo, Deborah R. Caswell, Sareena Rana, Christopher Moore, Edurne Mugarza, Kevin W. Ng, Matthew A. Coelho, Pablo Romero-Clavijo, Emily K. Law, Sophie de Carné Trécesson, Jesse Boumelha
Supplementary Table from An Immunogenic Model of KRAS-Mutant Lung Cancer Enables Evaluation of Targeted Therapy and Immunotherapy Combinations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5646e5b6edd1bf21906dd5a24045f7ea
https://doi.org/10.1158/0008-5472.22432356.v1
https://doi.org/10.1158/0008-5472.22432356.v1