Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Sarah J. Radford"'
Publikováno v:
PLoS Genetics, Vol 11, Iss 10, p e1005605 (2015)
In oocytes, where centrosomes are absent, the chromosomes direct the assembly of a bipolar spindle. Interactions between chromosomes and microtubules are essential for both spindle formation and chromosome segregation, but the nature and function of
Externí odkaz:
https://doaj.org/article/bab478507614456e88f251f7322e57bb
Autor:
Xin Zhang, Chen Liu, Sarah J. Radford, Steven K. Libutti, Ziqiang Yuan, Xiaowen Wang, X. F.Steven Zheng
Publikováno v:
Cell reports
SUMMARY Rab1A is a small GTPase known for its role in vesicular trafficking. Recent evidence indicates that Rab1A is essential for amino acids (aas) sensing and signaling to regulate mTORC1 in normal and cancer cells. However, Rab1A’s in vivo funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97e18b9973b01aae0e94f3262bd8cc4
https://pubmed.ncbi.nlm.nih.gov/33730578
https://pubmed.ncbi.nlm.nih.gov/33730578
Autor:
Hunter L Blanton, Sarah J Radford, Susan McMahan, Hutton M Kearney, Joseph G Ibrahim, Jeff Sekelsky
Publikováno v:
PLoS Genetics, Vol 1, Iss 3, p e40 (2005)
Crossovers ensure the accurate segregation of homologous chromosomes from one another during meiosis. Here, we describe the identity and function of the Drosophila melanogaster gene recombination defective (rec), which is required for most meiotic cr
Externí odkaz:
https://doaj.org/article/be58af5c2665467fbb28e08d2c9185d3
Autor:
Sarah J, Radford, Kim S, McKim
Publikováno v:
Journal of visualized experiments : JoVE. (116)
Chromosome segregation in human oocytes is error prone, resulting in aneuploidy, which is the leading genetic cause of miscarriage and birth defects. The study of chromosome behavior in oocytes from model organisms holds much promise to uncover the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fafba56e90506c5151b4f6e96113b583
https://pubmed.ncbi.nlm.nih.gov/27842371
https://pubmed.ncbi.nlm.nih.gov/27842371
Publikováno v:
Chromosoma. 126(3)
Several aspects of meiosis are impacted by the absence of centrosomes in oocytes. Here we review four aspects of meiosis I that are significantly affected by the absence of centrosomes in oocyte spindles. One, microtubules tend to assemble around the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67cebd39cc2f9665bd5b598f278c522e
https://pubmed.ncbi.nlm.nih.gov/27837282
https://pubmed.ncbi.nlm.nih.gov/27837282
Publikováno v:
Genetics. 205(2)
The oocyte spindle in most animal species is assembled in the absence of the microtubule-organizing centers called centrosomes. Without the organization provided by centrosomes, acentrosomal meiotic spindle organization may rely heavily on the bundli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d77f5a53bb6896d1e25351a1b7a75aa
https://pubmed.ncbi.nlm.nih.gov/27932541
https://pubmed.ncbi.nlm.nih.gov/27932541
Publikováno v:
Genetics. 192:417-429
DURING meiosis in the females of many species, spindle assembly occurs in the absence of the microtubule-organizing centers called centrosomes. In the absence of centrosomes, the nature of the chromosome-based signal that recruits microtubules to pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057befcde49b4da8392e6b82c0245d01
https://doi.org/10.1534/genetics.112.143495
https://doi.org/10.1534/genetics.112.143495
Autor:
Gohta Goshima, A. Agata Głuszek, Kim S. McKim, Mariana F A Costa, Hiroyuki Ohkura, Rachel A. Battaglia, Wenjing Li, C. Fiona Cullen, Sarah J. Radford
Publikováno v:
Głuszek, A A, Cullen, C F, Li, W, Battaglia, R A, Radford, S J, Costa, M F, McKim, K S, Goshima, G & Ohkura, H 2015, ' The microtubule catastrophe promoter Sentin delays stable kinetochore-microtubule attachment in oocytes ', Journal of Cell Biology, vol. 211, no. 6, pp. 1113-20 . https://doi.org/10.1083/jcb.201507006
The Journal of Cell Biology
The Journal of Cell Biology
The microtubule catastrophe-promoting complex Sentin-EB1 delays stable kinetochore–microtubule attachment and facilitates bipolar attachment of homologous chromosomes in Drosophila oocytes.
The critical step in meiosis is to attach homologous
The critical step in meiosis is to attach homologous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::defe39af59cd131e40be14937d9ee710
https://www.pure.ed.ac.uk/ws/files/22100022/The_microtubule_catastrophe_promoter_Sentin_delays_stable.....pdf
https://www.pure.ed.ac.uk/ws/files/22100022/The_microtubule_catastrophe_promoter_Sentin_delays_stable.....pdf
Autor:
Leigh Zimmerman, Daniel P. Haeusser, Catherine J Sheely, Meredith L Boyle, Joel E. Graham, Jill B. Keeney, Sarah J. Radford
Publikováno v:
Genetics. 168:89-101
Transposition of the Ty1 element of the yeast Saccharomyces cerevisiae is temperature sensitive. We have identified a null allele of the silent information regulator gene SIR4 as a host mutant that allows for transposition at high temperature. We sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb304dab0616070b0e10a69a50aceb9
https://doi.org/10.1534/genetics.102.012708
https://doi.org/10.1534/genetics.102.012708
Publikováno v:
Genetics. 192(2)
During cell division, a bipolar array of microtubules forms the spindle through which the forces required for chromosome segregation are transmitted. Interestingly, the spindle as a whole is stable enough to support these forces even though it is com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b232bfea6d54963a7740cf5d09f56a6
https://pubmed.ncbi.nlm.nih.gov/22865737
https://pubmed.ncbi.nlm.nih.gov/22865737