Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sarah J. Neering"'
Autor:
Patricia Greninger, Jane L. Liesveld, Kevin P. Callahan, Shanshan Pei, Jeffrey Settleman, Cyril H. Benes, Cheryl Corbett, John M. Ashton, Michael W. Becker, Fred K. Hagen, Peter A. Crooks, Haobin Ye, Mohammad Minhajuddin, Zheng Li, Eleni D. Lagadinou, Joshua Munger, Kristen M. O'Dwyer, Lei Shi, Sarah J. Neering, Craig T. Jordan, Marlene Balys
Publikováno v:
Journal of Biological Chemistry. 288:33542-33558
The development of strategies to eradicate primary human acute myelogenous leukemia (AML) cells is a major challenge to the leukemia research field. In particular, primitive leukemia cells, often termed leukemia stem cells, are typically refractory t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d3e2ab293929403d191dda5f474f6f8
https://doi.org/10.1074/jbc.m113.511170
https://doi.org/10.1074/jbc.m113.511170
Autor:
Duane C. Hassane, Craig T. Jordan, Helene R. McMurray, John M. Ashton, Peter Miller, Hartmut Land, Sarah J. Neering, Marlene Balys, Glenn S. Cowley, David E. Root, Benjamin L. Ebert
Publikováno v:
Cell Stem Cell. 11:359-372
SummaryLeukemia stem cells (LSCs) represent a biologically distinct subpopulation of myeloid leukemias, with reduced cell cycle activity and increased resistance to therapeutic challenge. To better characterize key properties of LSCs, we employed a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2fc675c818eb4cceed59c55e667a08
https://doi.org/10.1016/j.stem.2012.05.024
https://doi.org/10.1016/j.stem.2012.05.024
Autor:
Barry Grimes, Selina M. Luger, Dianna S. Howard, Sarah J. Neering, Monica L. Guzman, Donna Upchurch, Craig T. Jordan, David A. Rizzieri
Publikováno v:
Blood. 98:2301-2307
Human acute myelogenous leukemia (AML) is thought to arise from a rare population of malignant stem cells. Cells of this nature, herein referred to as leukemic stem cells (LSCs), have been documented for nearly all AML subtypes and appear to fulfill
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e18a00a712e4e7f690e482bfbdbdf5b7
https://doi.org/10.1182/blood.v98.8.2301
https://doi.org/10.1182/blood.v98.8.2301
Publikováno v:
Blood. 88:1147-1155
We have examined the ability of recombinant adenoviral vectors to transduce human hematopoietic cells. Our findings indicate that adenovirus readily infects a large proportion of CD34+ cells. Using adenovirus vectors that transduce either a lacZ or a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c64b98450ad211d68d8e10c50a85f4b
https://doi.org/10.1182/blood.v88.4.1147.bloodjournal8841147
https://doi.org/10.1182/blood.v88.4.1147.bloodjournal8841147
Autor:
Deborah R. Bell, Craig T. Jordan, Timothy P. Bushnell, David Heinrich, Andrea Bottaro, Pin-Yi Wang, Randall M. Rossi, Sarah J. Neering, John M. Ashton, Selcuk Sozer
Myeloid leukemia arises from leukemia stem cells (LSCs), which are resistant to standard chemotherapy agents and likely to be a major cause of drug-resistant disease and relapse. To investigate the in vivo properties of LSCs, we developed a mouse mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a569653f65eddf31ea1bb88fec5bbcd6
https://europepmc.org/articles/PMC1988942/
https://europepmc.org/articles/PMC1988942/
Autor:
Ivan Topisirovic, Melanie J. McConnell, Katherine L. B. Borden, Jonathan D. Licht, Biljana Culjkovic, Craig T. Jordan, Sarah J. Neering, Monica L. Guzman
The eukaryotic translation initiation factor 4E (eIF4E) acts as both a key translation factor and as a promoter of nucleocytoplasmic transport of specific transcripts. Traditionally, its transformation capacity in vivo is attributed to its role in tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a430dc50d74d64a84b94b4f410853d8
https://europepmc.org/articles/PMC309660/
https://europepmc.org/articles/PMC309660/
Autor:
Shanshan Pei, Craig T. Jordan, Eleni D. Lagadinou, Randall M. Rossi, Paul S. Brookes, Alexander Sach, Kristen M. O'Dwyer, Michael W. Becker, Kevin P. Callahan, Jane L. Liesveld, Sarah J. Neering
Publikováno v:
Blood. 120:206-206
Abstract 206 Targeting leukemia stem cells (LSCs) is a priority for the development of improved therapeutic regimens. However, the intrinsic heterogeneity of malignant populations in acute myelogenous leukemia (AML) has made it challenging to identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7919c9851771a431a0fc3689423d6d70
https://doi.org/10.1182/blood.v120.21.206.206
https://doi.org/10.1182/blood.v120.21.206.206
Autor:
Jane L. Liesveld, Sarah J. Neering, Fred K. Hagen, Marlene Balys, Cheryl Corbett, Craig T. Jordan, Mohammad Minhajuddin, Kevin P. Callahan, Shanshan Pei, Alan E. Friedman, Michael W. Becker, Peter A. Crooks
Publikováno v:
Blood. 118:3506-3506
Abstract 3506 Many studies have indicated that induction of oxidative stress is one component of the mechanism by which anti-leukemia agents function. However, little is known about the differences between leukemic and normal redox homeostasis, and w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7931eaaf6026a5dacdf366f58e345fa
https://doi.org/10.1182/blood.v118.21.3506.3506
https://doi.org/10.1182/blood.v118.21.3506.3506
Autor:
Glenn S. Cowley, Marlene Balys, Craig T. Jordan, Duane C. Hassane, Benjamin L. Ebert, Helene R. McMurray, David E. Root, Peter Miller, Sarah J. Neering, Hartmut Land, John M. Ashton
Publikováno v:
Blood. 118:553-553
Abstract 553 In order to increase our understanding of key biological properties governing the development of leukemia stem cells (LSCs), we employed a novel gene identification strategy based on cooperation between initiating oncogenes. Previous stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e178dc51ee46a69345d7639608461aab
https://doi.org/10.1182/blood.v118.21.553.553
https://doi.org/10.1182/blood.v118.21.553.553
Autor:
Cheryl Corbett, Randall M. Rossi, Eleni D. Lagadinou, Kevin P. Callahan, Marlene Balys, Paul S. Brookes, Valerie Grose, Sarah J. Neering, Shanshan Pei, Mohammad Minhajuddin, Craig T. Jordan
Publikováno v:
Blood. 118:639-639
Abstract 639 Failure to eliminate leukemia stem cells (LSC) appears to be a major limitation of standard regimens and a significant challenge in the development of improved therapies. To effectively target LSC, it is essential to unravel the unique f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3be53491106747993e93a167e8876f0
https://doi.org/10.1182/blood.v118.21.639.639
https://doi.org/10.1182/blood.v118.21.639.639