Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Sarah J. Luchansky"'
Autor:
Carlos G. Sanchez, Christopher M. Acker, Audrey Gray, Malini Varadarajan, Cheng Song, Nadire R. Cochran, Steven Paula, Alicia Lindeman, Shaojian An, Gregory McAllister, John Alford, John Reece-Hoyes, Carsten Russ, Lucas Craig, Ketthsy Capre, Christian Doherty, Gregory R. Hoffman, Sarah J. Luchansky, Manuela Polydoro, Ricardo Dolmetsch, Fiona Elwood
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Using an unbiased genome-wide CRISPR screen approach, Sanchez et al. identified modulators of endogenous tau protein. This study suggests that chromatin modifiers, neddylation, ubiquitination, and the mTOR pathways regulate overall levels of tau prot
Externí odkaz:
https://doaj.org/article/a6974f96fa3e43eca73250a0892da4a2
Autor:
Fiona Elwood, John Alford, Carsten Russ, Christopher Acker, Audrey Gray, John S. Reece-Hoyes, Carlos G Sanchez, Sarah J. Luchansky, Christian Doherty, Lucas Craig, Gregory McAllister, Steven Paula, Ricardo E. Dolmetsch, Shaojian An, Cheng Song, Alicia Lindeman, Malini Varadarajan, Nadire Cochran, Manuela Polydoro, Ketthsy Capre, Gregory R. Hoffman
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology
Communications Biology
Aggregates of hyperphosphorylated tau protein are a pathological hallmark of more than 20 distinct neurodegenerative diseases, including Alzheimer’s disease, progressive supranuclear palsy, and frontotemporal dementia. While the exact mechanism of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a06bbe1da74cbde2af5f7fb1d3fc80e
https://doaj.org/article/a6974f96fa3e43eca73250a0892da4a2
https://doaj.org/article/a6974f96fa3e43eca73250a0892da4a2
Autor:
Markus Schirle, Bertran Gerrits, Joel W. Thompson, Andreas Bauer, Jane Nagel, Sarah J. Luchansky, Marc W. Kirschner, Jason R. Thomas, Sjouke Hoving
Publikováno v:
Journal of Biological Chemistry. 289:28942-28955
Targeted degradation of proteins through the ubiquitin-proteasome system (UPS) via the activities of E3 ubiquitin ligases regulates diverse cellular processes, and misregulation of these enzymes contributes to the pathogenesis of human diseases. One
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6cd12d755dded51d3827b031394d260
https://doi.org/10.1074/jbc.m114.573352
https://doi.org/10.1074/jbc.m114.573352
Autor:
Richard Hughes, Guiqing Liang, Jeffrey Shapiro, Zhao Yan, Rishi K. Jain, Sarah J. Luchansky, Luis Llamas, Vidya Kunjathoor, Jill Nunez, Stefan Peukert, Michael Pietropaolo, Avirup Bose, Xiaoping Wu, Adam Carlson, Anja Castellana, Guo He
Publikováno v:
ACS Medicinal Chemistry Letters. 5:1114-1118
The identification of highly potent and orally bioavailable GPR39 agonists is reported. Compound 1, found in a phenotypic screening campaign, was transformed into compound 2 with good activity on both the rat and human GPR39 receptor. This compound w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77b74a6ceb7a900ba594576e284a9f76
https://doi.org/10.1021/ml500240d
https://doi.org/10.1021/ml500240d
Autor:
Heinz Ruffner, Fred Harbinski, Arun Ramamurthy, Jeremy L. Jenkins, Tewis Bouwmeester, Lac Lee, Paola Grandi, Jennifer A. DaSilva, Barbara Wilmeringwetter, Rishi K. Jain, Showalter Todd, Luis Llamas, Frederic Bassilana, Aaron Bourret, Adam Carlson, Jeffrey A. Porter, Xu Wu, Solange Vidal, Peter M. Finan, Pascal Rigollier, Markus Schirle, Joseph Kelleher, Bianka L. Grosshans, Klaus Seuwen, Samantha Plonsky, John A. Tallarico, Valerie Beck, Andreas W. Sailer, Sarah J. Luchansky, Vic E. Myer
Publikováno v:
Nature Chemical Biology. 10:343-349
Hedgehog (Hh) signaling determines cell fate during development and can drive tumorigenesis. We performed a screen for new compounds that can impinge on Hh signaling downstream of Smoothened (Smo). A series of cyclohexyl-methyl aminopyrimidine chemot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776a437136d93c82505cb7a23b5e468a
https://doi.org/10.1038/nchembio.1481
https://doi.org/10.1038/nchembio.1481
Publikováno v:
ChemBioChem. 5:1706-1709
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4152613ff21070394d6430546f768900
https://doi.org/10.1002/cbic.200400148
https://doi.org/10.1002/cbic.200400148
Publikováno v:
Luchansky, Sarah J.; Yarema, Kevin J.; Takahashi, Saori; & Bertozzi, Carolyn R.(2003). GlcNAc 2-epimerase can serve a catabolic role in sialic acid metabolism. Journal of Biological Chemistry, 278(10). Lawrence Berkeley National Laboratory: Lawrence Berkeley National Laboratory. Retrieved from: http://www.escholarship.org/uc/item/4zw820nk
Sialic acid is a major determinant of carbohydrate-receptor interactions in many systems pertinent to human health and disease. N-Acetylmannosamine (ManNAc) is the first committed intermediate in the sialic acid biosynthetic pathway; thus, the mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aaebce22201151130341f944b170fb9
https://doi.org/10.1074/jbc.m212127200
https://doi.org/10.1074/jbc.m212127200
Autor:
Zainab Jagani, Jill P. Mesirov, Pablo Tamayo, William R. Sellers, Dongshu Chen, Boris G. Wilson, Marion Dorsch, Michael Y. Tolstorukov, Silvia Buonamici, Joshua Murtie, E. Lorena Mora-Blanco, Markus Warmuth, Charles W. M. Roberts, Yoon Jae Cho, Scott L. Pomeroy, Heinz Ruffner, Phuong L. Nguyen, Sarah J. Luchansky, Joseph Kelleher, Courtney G. Sansam, Tewis Bouwmeester, Justin Klekota, Kathy Hsiao, Peter J. Park, Elizabeth S. McKenna
Aberrant activation of the Hedgehog (Hh) pathway can drive tumorigenesis1. To investigate the mechanism by which glioma-associated oncogene family zinc finger-1 (GLI1), a crucial effector of Hh signaling2, regulates Hh pathway activation, we searched
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b54336cefbe92240381d8da321a9802
https://europepmc.org/articles/PMC3859448/
https://europepmc.org/articles/PMC3859448/
Autor:
Dagmar Ringe, Chittaranjan Das, Peter T. Lansbury, Gregory A. Petsko, Cheryl A. Kreinbring, Quyen Q. Hoang, Robin K. Meray, Sarah J. Luchansky, Soumya S. Ray
The ubiquitin C-terminal hydrolase UCH-L1 (PGP9.5) comprises >1% of total brain protein but is almost absent from other tissues [Wilkinson, K. D., et al. (1989) Science 246, 670–673]. Mutations in the UCH-L1 gene have been reported to be linked to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c4f68f18845c61e98bffcec9fe2239
https://europepmc.org/articles/PMC1450230/
https://europepmc.org/articles/PMC1450230/
Publikováno v:
Biochemistry. 43(38)
Glycoproteins are essential for cellular communication and are the most rapidly growing class of therapeutic agents. Chemical modification of glycoproteins has been employed to improve their in vivo efficacy or to label them for detection. Methods fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab2f37a770783a4616d02d551488ba30
https://pubmed.ncbi.nlm.nih.gov/15379575
https://pubmed.ncbi.nlm.nih.gov/15379575