Výsledky vyhledávání - "Sarah J. Knott"

Bacteriological Efficacies of Three Macrolides Compared with Those of Amoxicillin-Clavulanate against Streptococcus pneumoniae and Haemophilus influenzae

Autor: Christine E. Thorburn, Gary Woodnutt, Sarah J. Knott, Valerie Berry

Publikováno v: Antimicrobial Agents and Chemotherapy. 42:3193-3199

Comparative antibacterial efficacies of erythromycin, clarithromycin, and azithromycin were examined against Streptococcus pneumoniae and Haemophilus influenzae , with amoxicillin-clavulanate used as the active control. In vitro, the macrolides at tw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17466e5b539a70a7e96c6656c82361ef
https://doi.org/10.1128/aac.42.12.3193

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In Vitro Activities of Oral β-Lactams at Concentrations Achieved in Humans against Penicillin-Susceptible and -Resistant Pneumococci and Potential to Select Resistance

Autor: Sarah J. Knott, David I. Edwards, Christine E. Thorburn

Publikováno v: Antimicrobial Agents and Chemotherapy. 42:1973-1979

The β-lactam susceptibilities of 65 strains of Streptococcus pneumoniae for which penicillin MICs covered a broad range were assessed. The order of potency was amoxicillin (AMX) = amoxicillin-clavulanate (AMC) > penicillin G > cefpodoxime (CPO) > ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7411ada2975ab48d109c56d8a8bc841f
https://doi.org/10.1128/aac.42.8.1973

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Novel C-2 Substituted Carbapenem Derivatives. Part IV. Synthesis and Biological Activity of Five Membered Heteroaromatic Derivatives

Autor: Eric Hunt, Andrew K. Takle, A. J. Eglington, J. D. Hinks, Steven Coulton, George Burton, S. F. Moss, Antoinette Naylor, R K Holland, Michael J. Pearson, Clive Leslie Branch, Sarah J. Knott, G. J. Clarke, J. D. Douglas, A. W. Guest, N. W. Hird

Publikováno v: The Journal of Antibiotics. 51:210-220

The synthesis, antibacterial activity, and stability to human dehydropeptidase-1 (DHP-1) of a novel series of (5R,6S)-6-[(1R)-1-hydroxyethyl]-2-heterocyclylcarbapen-2-em-3-carb oxylates are described. Of the compounds investigated 1,5-disubstituted p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc65dfc9bf1565bcb86dccd413428f00
https://doi.org/10.7164/antibiotics.51.210

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Synthesis and biological properties of some 3-((N-subtstituted-amino)pyridinium-4-thiomethyl)-7-((2-amino-thiazol-4-yl)-2-(Z)-(methoxyimino)acetamido)ceph-3-em-4-carboxylates

Autor: Iskander I. Zomaya, Edward G. Brain, Frank P. Harrington, Angela W. Guest, Michael J. Pearson, Clive Leslie Branch, Richard G. Adams, Sarah J. Knott

Publikováno v: The Journal of Antibiotics. 46:1289-1299

The synthesis and antibacterial activity of a series of β-lactamase stable, broad spectrum 7-[2-(2-amino-thiazol-4-yl)-2-(Z)-(methoxyimino)acetamido]-cephalosporins, characterised by a C-3-[N-(substituted-amino)pyridinium-4-thiomethyl] group, is des

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce3a659a132ca71cf2c28b9e9dba9687
https://doi.org/10.7164/antibiotics.46.1289

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Structure-activity relationships of some arylglycine analogues and catechol isosteres of BRL 36650, a 6.ALPHA.-formamido penicillin

Autor: David T. Davies, Desmond John Best, Andrew V. Stachulski, George Burton, Terence C. Smale, Robert Southgate, John S. Elder, Sarah J. Knott, Michael J. Basker

Publikováno v: The Journal of Antibiotics. 43:574-577

The catecholic acylureido derivative BRL 36650 was the most potent, especially against Pseudomonas aeruginosa strains. We now report on analogues of 1 which either retain a catechol or dihydroxyphenyl unit or contain various catechol isosteres.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59cae026828d392eab8d9dd5bf9193fc
https://doi.org/10.7164/antibiotics.43.574

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Studies on semi-synthetic 7.ALPHA.-formamidocephalosporins. III. Synthesis and antibacterial activity of some 7.BETA.-(D-2-(aryl)-2-((4-ethyl-2,3-dioxopiperazin-1-yl)-carbonylamino)acetamido)-7.ALPHA.-formamido-ceph-3-em-4-carboxylate derivatives

Autor: Stephen Christopher Finch, Arun C. Kaura, Peter H. Milner, Michael J. Pearson, Michael J. Basker, Frank P. Harrington, A. W. Guest, Clive Leslie Branch, Sarah J. Knott

Publikováno v: The Journal of Antibiotics. 40:646-651

The synthesis and antibacterial activity of 7 beta-[D-2-(aryl)-2-[(4-ethyl-2,3-dioxopiperazin-1-yl) carbonylamino] acetamido]-7 alpha-formamidocephalosporins with various substituents at the C-3 position of the cephalosporin nucleus is described. Inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d7a5ba219e811f20b8e596934ef150e
https://doi.org/10.7164/antibiotics.40.646

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Synthesis and biological activity of a series of piperazine-2,3-dione containing penicillins and 6 alpha-formamidopenicillins. I. Derivatives substituted at C(5) or C(6) of the piperazine ring

Autor: David T. Davies, Sarah J. Knott, Frank P. Harrington, Robert Southgate

Publikováno v: The Journal of antibiotics. 42(3)

The synthesis and antibacterial activity of a series of penicillins and 6 alpha-formamidopenicillins containing a C(5) or C(6)-substituted piperazine-2,3-dione moiety in the C(6)-beta-sidechain is described.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19ffd189adb5710b1a3d3b969dcc361
https://pubmed.ncbi.nlm.nih.gov/2708129

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Structure-activity relationships in a series of piperazine-2,3-dione containing penicillins and cephalosporins. II. Derivatives substituted at N(4) of the piperazine ring

Autor: Robert Southgate, Frank P. Harrington, Peter J. O'hanlon, Sarah J. Knott

Publikováno v: The Journal of antibiotics. 42(8)

Preparation d'analogues des penicillines et des cephalosporines ayant une activite biologique amelioree et un spectre antibacterien elargi en modifiant les substituants sur l'azote du cycle piperazine-2,3-dione

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db37ebe28fee1ea5b83193c6f7a62a7
https://pubmed.ncbi.nlm.nih.gov/2759906

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