Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Sarah J. Horton"'
Autor:
Sarah J. Horton, Brian J.P. Huntly
Publikováno v:
Haematologica, Vol 97, Iss 7 (2012)
The existence of cancer stem cells has long been postulated, but was proven less than 20 years ago following the demonstration that only a small sub-fraction of leukemic cells from acute myeloid leukemia patients were able to propagate the disease in
Externí odkaz:
https://doaj.org/article/de3a5e95b1e446dcbeabde4ba2e731c7
Autor:
Owen Williams, Hugh J.M. Brady, Terence R.J. Lappin, Dimitris Kioussis, Dale A. Moulding, Inusha De Silva, Michelle Morrow, Alexander Thompson, Glenda J. McGonigle, David G. Grier, Sarah J. Horton
Supplementary Methods and Legends from Continuous MLL-ENL Expression Is Necessary to Establish a “Hox Code” and Maintain Immortalization of Hematopoietic Progenitor Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291039d748a8ee9cf20cb7040c222116
https://doi.org/10.1158/0008-5472.22364975.v1
https://doi.org/10.1158/0008-5472.22364975.v1
Autor:
Owen Williams, Hugh J.M. Brady, Terence R.J. Lappin, Dimitris Kioussis, Dale A. Moulding, Inusha De Silva, Michelle Morrow, Alexander Thompson, Glenda J. McGonigle, David G. Grier, Sarah J. Horton
Supplementary Figures S1-S4, Table 1 from Continuous MLL-ENL Expression Is Necessary to Establish a “Hox Code” and Maintain Immortalization of Hematopoietic Progenitor Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::171ca47e665996a6c9333cd0066c052d
https://doi.org/10.1158/0008-5472.22364978
https://doi.org/10.1158/0008-5472.22364978
Autor:
Owen Williams, Hugh J.M. Brady, Terence R.J. Lappin, Dimitris Kioussis, Dale A. Moulding, Inusha De Silva, Michelle Morrow, Alexander Thompson, Glenda J. McGonigle, David G. Grier, Sarah J. Horton
The t[(11;19)(p22;q23)] translocation, which gives rise to the MLL-ENL fusion protein, is commonly found in infant acute leukemias of both the myeloid and lymphoid lineage. To investigate the molecular mechanism of immortalization by MLL-ENL we estab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c300a15dee575d3b3cc1b1aee9da2c1
https://doi.org/10.1158/0008-5472.c.6494468
https://doi.org/10.1158/0008-5472.c.6494468
Autor:
Shuchi Agrawal-Singh, Jaana Bagri, George Giotopoulos, Dhoyazan M. A. Azazi, Sarah J. Horton, Cecile K. Lopez, Shubha Anand, Anne-Sophie Bach, Frances Stedham, Robin Antrobus, Jack W. Houghton, George S. Vassiliou, Daniel Sasca, Haiyang Yun, Anthony D. Whetton, Brian J. P. Huntly
HOXA9 is commonly upregulated in acute myeloid leukemia (AML), in which it confers a poor prognosis. Characterizing the protein interactome of endogenous HOXA9 in human AML, we identified a chromatin complex of HOXA9 with the nuclear matrix attachmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3adbe43d1d79de2094f6b253d19fc9
Autor:
Oliver M. Dovey, Pedro Madrigal, Paolo Gallipoli, George S. Vassiliou, Haiyang Yun, Cameron S. Osborne, Shuchi Agrawal-Singh, Annalisa Mupo, Shabana Vohra, David Lara-Astiaso, Aracely Castillo-Venzor, Faisal Basheer, Sarah J. Horton, Brian J. P. Huntly, Ludovica Marando, Malgorzata Gozdecka, Eshwar Meduri, Carsten Müller-Tidow, Daniel Sasca, George Giotopoulos, Xiaonan Wang, Nisha Narayan
Publikováno v:
Nature Genetics. 53:1443-1455
Altered transcription is a cardinal feature of acute myeloid leukemia (AML); however, exactly how mutations synergize to remodel the epigenetic landscape and rewire three-dimensional DNA topology is unknown. Here, we apply an integrated genomic appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::167b3ec8428ace067c05deac35f64a8b
https://doi.org/10.1038/s41588-021-00925-9
https://doi.org/10.1038/s41588-021-00925-9
Autor:
Shuchi Agrawal Singh, Jaana Bagri, George Giotopoulos, Dhoyazan Azazi, Shubha Anand, Anne-Sophie Bach, Frances Stedham, Sarah J. Horton, Robin Antrobus, Jack W. Houghton, George S. Vassiliou, Daniel Sasca, Haiyang Yun, Anthony D. Whetton, Brian J.P. Huntly
HOXA9is commonly upregulated in acute myeloid leukemia (AML), where it confers poor prognosis. Characterising the protein interactome of endogenous HOXA9 in human AML, we identified a chromatin complex of HOXA9 with the nuclear matrix attachment prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62a3d3b93e16667dece75d4af728e86c
https://doi.org/10.1101/2022.10.12.511919
https://doi.org/10.1101/2022.10.12.511919
Autor:
Viral Shah, George Giotopoulos, Hikari Osaki, Markus Meyerhöfer, Eshwar Meduri, Benedict Schubert, Haiyang Yun, Sarah J Horton, Shuchi Agrawal-Singh, Patricia S Haehnel, Faisal Basheer, Dave Lugo, Michael WM Kühn, Borhane Guezguez, Matthias Theobald, Thomas Kindler, Paolo Gallipoli, Rab K Prinjha, Brian JP Huntly, Daniel Sasca
Initial clinical trials with drugs targeting epigenetic modulators - such as bromodomain and extraterminal (BET) inhibitors - demonstrate modest results in acute myeloid leukemia (AML). The main reason for this involves an increased transcriptional p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99d2692ba4e1ae6a1d89938b2c1a17d9
https://doi.org/10.1101/2022.09.14.507850
https://doi.org/10.1101/2022.09.14.507850
Autor:
Marco Carretta, Annet Z Brouwers-Vos, Matthieu Bosman, Sarah J Horton, Joost H A Martens, Edo Vellenga, Jan Jacob Schuringa
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189102 (2017)
In the present work we aimed to identify targetable signaling networks in human MLL-AF9 leukemias. We show that MLL-AF9 cells critically depend on FLT3-ligand induced pathways as well as on BRD3/4 for their survival. We evaluated the in vitro and in
Externí odkaz:
https://doaj.org/article/b1805072dfc34bbfa2edac39950bafeb
Autor:
Shuchi Agrawal Singh, Jaana Bagri, George Giotopoulos, Eshwar Meduri, Shubha Anad, Sarah J. Horton, Daniel Sasca, Haiyang Yun, Anthony Whetton, Brian James Patrick Huntly
Publikováno v:
Blood. 140:720-721
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae817661f61d77e0dcf8e9818b618696
https://doi.org/10.1182/blood-2022-156341
https://doi.org/10.1182/blood-2022-156341