Naturally-acquired influenza-specific CD4+ T-cell proliferative responses are impaired in HIV-infected African adults.

Autor: Kondwani C Jambo, Enoch Sepako, Sarah J Glennie, David Mzinza, Neil A Williams, Stephen B Gordon, Robert S Heyderman

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e38628 (2012)

Seasonal influenza has been associated with greater morbidity and mortality in AIDS patients. Highly-active antiretroviral therapy (HAART) has led to some reduction in influenza-related complications but the nature of naturally-acquired T-cell immuni

Externí odkaz: https://doaj.org/article/2927e215f38e4cdb8961e0a2146e5efa

Impaired CD4 T cell memory response to Streptococcus pneumoniae precedes CD4 T cell depletion in HIV-infected Malawian adults.

Autor: Sarah J Glennie, Enoch Sepako, David Mzinza, Visopo Harawa, David J C Miles, Kondwani C Jambo, Stephen B Gordon, Neil A Williams, Robert S Heyderman

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e25610 (2011)

Invasive pneumococcal disease (IPD) is a leading cause of morbidity and mortality in HIV-infected African adults. CD4 T cell depletion may partially explain this high disease burden but those with relatively preserved T cell numbers are still at incr

Externí odkaz: https://doaj.org/article/fbe83137189c4250bec91b8e04ad2d3b

A Modular Vaccine Platform Combining Self-Assembled Peptide Cages and Immunogenic Peptides

Autor: Andrew D. Davidson, Dhinushi Kandage, David J. Morgan, Caroline Morris, Derek N. Woolfson, Hon S. Lam, Neil A. Williams, Sarah J. Glennie, Holly Baum

Publikováno v: Advanced Functional Materials
Morris, C, Glennie, S, Lam, H, Baum, H, Kandage, D, Williams, N, Morgan, D, Woolfson, D & Davidson, A 2019, ' A Modular Vaccine Platform Combining Self-Assembled Peptide Cages and Immunogenic Peptides ', Advanced Functional Materials, vol. 29, no. 8, 1807357 . https://doi.org/10.1002/adfm.201807357

Subunit vaccines use delivery platforms to present minimal antigenic components for immunization. The benefits of such systems include multivalency, self‐adjuvanting properties, and more specific immune responses. Previously, the design, synthesis,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f88c89bb8ca28e9b115c2bdcb479cc20
https://pubmed.ncbi.nlm.nih.gov/32313545

Sequential Acquisition of T Cells and Antibodies to Nontyphoidal Salmonella in Malawian Children

Autor: Calman A. MacLennan, Melita A. Gordon, James J. Gilchrist, Tonney S. Nyirenda, Naor Bar-Zeev, Nicholas A. Feasey, Robert S. Heyderman, Sarah J. Glennie, Wilson L. Mandala

Publikováno v: The Journal of Infectious Diseases

Background. Salmonella Typhimurium (STm) remain a prominent cause of bacteremia in sub-Saharan Africa. Complement-fixing antibodies to STm develop by 2 years of age. We hypothesized that STm-specifi cC D4 + T cells develop alongside this process. Met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c0c41e2ac52e2d88127d32314e09c9b
http://europepmc.org/articles/PMC4054899

Bronchoalveolar CD4+ T cell responses to respiratory antigens are impaired in HIV-infected adults

Autor: Adam K. A. Wright, Robert S. Heyderman, Kondwani C. Jambo, Stephen B. Gordon, Duncan G. Fullerton, Enoch Sepako, David Mzinza, Sarah J. Glennie

Publikováno v: Thorax

Rationale \ud \ud HIV-infected adults are at an increased risk of lower respiratory tract infections. HIV infection impairs systemic acquired immunity, but there is limited information in humans on HIV-related cell-mediated immune defects in the lung

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb16a5474bac1fc78d0c814099b6ce7
http://europepmc.org/articles/PMC3088469