Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Sarah J. Cully"'
Autor:
Benoit Carbain, Keisha Hearn, Ildiko Maria Buck, Burcu Anil, Sarah J. Cully, Gianni Chessari, Jane A. Endicott, John Lunec, Neil T. Thompson, Juan Castro, Roger J. Griffin, Rhian S. Holvey, Karen Haggerty, Charlotte H. Revill, Ruth H. Bawn, Stephen R. Wedge, Christiane Riedinger, Christopher N. Johnson, Bernard T. Golding, Lynsey Fazal, Ian R. Hardcastle, Mladen Vinkovic, Claire E. Jennings, Jong Sook Ahn, Bian Zhang, Pamela A. Williams, Celine Cano, Suzannah J. Harnor, Ben Cons, Stephen J. Hobson, E. Anscombe, Jeffrey D. St. Denis, Steven Howard, David R. Newell, Emiliano Tamanini, Nicola E. Wilsher, Miller Duncan Charles, Huw D. Thomas, Timothy J. Blackburn, Martin E.M. Noble, Judith Reeks, Yan Zhao, Luke Bevan
Publikováno v:
Journal of Medicinal Chemistry. 64:4071-4088
Inhibition of murine double minute 2 (MDM2)-p53 protein-protein interaction with small molecules has been shown to reactivate p53 and inhibit tumor growth. Here, we describe rational, structure-guided, design of novel isoindolinone-based MDM2 inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd2c962765a3d64c4d7d02d50fd31b0d
https://doi.org/10.1021/acs.jmedchem.0c02188
https://doi.org/10.1021/acs.jmedchem.0c02188
Autor:
Graham J. Jones, William Lewis, Ian Strutt, Robert A. Stockman, Daniel Hamza, W. A. Bawazir, Thomas E. Storr, M. S. I. T. Makki, Michael J. Rawling, Sarah J. Cully
Publikováno v:
Chemical Communications. 51:12867-12870
A heterocyclic, sp(3)-rich chemical scaffold was synthesised in just 6 steps via a highly regio- and diastereo-selective tandem nitrone formation/intramolecular nitrone-alkene [3+2] cycloaddition reaction. A library of 543 lead-like compounds based o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd53262856c4ae7db22dcc03fefc5486
https://doi.org/10.1039/c5cc05070g
https://doi.org/10.1039/c5cc05070g
Autor:
Abdul Quddus, Daniel Hamza, William Lewis, Michael J. Rawling, Geraint Jones, Robert A. Stockman, Christopher A. Pearce, Induka R. Abeysena, Sarah J. Cully, Thomas E. Storr
In order to address the current downturn in the drug discovery pipeline, initiatives are being undertaken to synthesise screening libraries of sp3-rich, low molecular weight compounds. As part of the European Lead Factory initiative, the synthesis an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c37591d978a99cf2761e6d4a3bf53b2e
http://eprints.nottingham.ac.uk/36176/
http://eprints.nottingham.ac.uk/36176/
Autor:
S Wedge, Roger J. Griffin, Maria Ahn, Karen Haggerty, Juan Castro, Ian R. Hardcastle, Celine Cano, Christopher N. Johnson, Bernard T. Golding, Herbie Newell, Steven Howard, Luke Bevan, Timothy J. Blackburn, Pamela A. Williams, Martin E.M. Noble, Yan Zhao, Judith Reeks, Ruth H. Bawn, Neil Thompson, Emiliano Tamanini, Ben Cons, Huw Thomas, Lynsey Fazal, Hugh Walton, Elaine Willmore, Sarah J. Cully, Gianni Chessari, Keisha Hearn, Ildiko Maria Buck
Publikováno v:
Cancer Research. 78:1652-1652
In response to cellular stress, the p53 tumor suppressor is activated to modulate cell cycle progression, DNA repair, and cell death. The activity of p53 is tightly regulated by MDM2, an E3 ubiquitin ligase that targets p53 for proteasomal degradatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f11828bba8837e5bc77a00d94f5218f
https://doi.org/10.1158/1538-7445.am2018-1652
https://doi.org/10.1158/1538-7445.am2018-1652
Autor:
Daniel Hamza, Geraint Jones, Robert A. Stockman, Michael J. Rawling, William Lewis, Sarah J. Cully, Thomas E. Storr
The application of a tandem condensation/cyclisation/[3+2]-cycloaddition/elimination reaction gives an sp(3)-rich tricyclic pyrazoline scaffold with two ethyl esters in a single step from a simple linear starting material. The successive hydrolysis a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::731b26e1332bd07a4bee2cb91c3815da
https://nottingham-repository.worktribe.com/file/750700/1/j.bmc.2014.12.050.pdf
https://nottingham-repository.worktribe.com/file/750700/1/j.bmc.2014.12.050.pdf
Autor:
Ian R. Hardcastle, Roger J. Griffin, Bernard T. Golding, Anna Watson, John Lunec, Sarah J. Cully, David R. Newell, Huw Thomas, Yan Zhao, Junfeng Liu, Timothy J. Blackburn
Publikováno v:
Cancer Research. 72:919-919
The potent and selective MDM2-p53 antagonist 4-chloro-3-(4-chlorophenyl)-3-((1-(hydroxymethyl)cyclopropyl)methoxy)-2-(4-nitrobenzyl)isoindolin-1-one 1 displays promising activity in cellular tumour models; however, poor solubility precludes in vivo i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b7e4fa2b280590a10711664110fb751
https://doi.org/10.1158/1538-7445.am2012-919
https://doi.org/10.1158/1538-7445.am2012-919