Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Sarah J. Crowe"'
Autor:
Raymond Jupp, Mark D. Stow, Keith Smith, Sarah J. Crowe, Annik K. Panicker, Jean-Pierre Guilloteau, Ashfaq Parkar
Publikováno v:
Protein Expression and Purification. 20:152-161
We have cloned, overexpressed, and purified the catalytic domain (residues Gly106 to Asn268) of human macrophage metalloelastase (MMP-12) in Escherichia coli. This construct represents a truncated form of the enzyme, lacking the N-terminal propeptide
Autor:
Christopher Adams, Jane E. Redford, Mark Vine, Keith Smith, Sue King, Lai Justine Yeun Quai, Colin P. Bright, Martyn Foster, Clive Mccarthy, Bamborough Paul Lindsay, John E. Souness, David J. Aldous, Sarah J. Crowe, Sukanthini Thurairatnam, Neil Moorcroft, Kenneth Page, Garry Fenton, Jean-Philippe Letallec, Paul R. Eastwood, Amendola Shelley, Christopher Lawrence, Sudha Rao, Barry M. Wyman, Shazia Sadiq, Trevor K.P. Harrison
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(18)
The utilization and impact of parallel synthesis on lead exploration around initial hit oxindole (1) are described. The emergent SAR, analogue design and functional impact will also be detailed.