Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Sarah J. Brustkern"'
Autor:
Robert J. Mourey, Matthew J. Saabye, Marvin J. Meyers, J. Scott Daniels, William F. Hood, Stephen J. Mnich, Jian Zhang, Jeffrey L. Hirsch, Sarah J. Brustkern, Betsy Pierce, Barry L. Burnette, David R. Anderson, John F. Schindler, Elizabeth G. Webb, Sarah A. South
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 333:797-807
Activation of the p38 kinase pathway in immune cells leads to the transcriptional and translational regulation of proinflammatory cytokines. Mitogen-activated protein kinase-activated protein kinase 2 (MK2), a direct downstream substrate of p38 kinas
Autor:
Matthew T. Reding, Horng-Chih Huang, Sumathy Mathialagan, Neetu Venkatraman, Jin Xie, Xiong Li, Sarah J. Brustkern, Gennadiy Poda, Shaun R. Selness, Serge G. Wolfson, Cynthia D. Sommers, Natalie X. Chen, Lori Christine, Yiding Hu, Nandini Kishore, Ravi G. Kurumbail, Sheri L. Bonar, Richard F. Heier, Patrick J. Lennon
Publikováno v:
Bioorganicmedicinal chemistry. 19(3)
Installation of sites for metabolism in the lead compound PHA-767408 was the key focus of the IKK-2 inhaled program. This paper reports our efforts to identify a novel series of aminopyridinecarboxamide-based IKK-2 inhibitors, which display low nanom