Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Sarah J. Backe"'
Autor:
Sarah J. Backe, Rebecca A. Sager, Jennifer A. Heritz, Laura A. Wengert, Katherine A. Meluni, Xavier Aran-Guiu, Barry Panaretou, Mark R. Woodford, Chrisostomos Prodromou, Dimitra Bourboulia, Mehdi Mollapour
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113672- (2024)
Externí odkaz:
https://doaj.org/article/9fda5e1eb2a7419281fc9e680ef89a78
Autor:
Sarah J. Backe, Rebecca A. Sager, Jennifer A. Heritz, Laura A. Wengert, Katherine A. Meluni, Xavier Aran-Guiu, Barry Panaretou, Mark R. Woodford, Chrisostomos Prodromou, Dimitra Bourboulia, Mehdi Mollapour
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112807- (2023)
Summary: Cellular homeostasis relies on both the chaperoning of proteins and the intracellular degradation system that delivers cytoplasmic constituents to the lysosome, a process known as autophagy. The crosstalk between these processes and their un
Externí odkaz:
https://doaj.org/article/4372f2b85d70407f912e42e25ea43467
Autor:
Sarah J. Backe, SarahBeth D. Votra, Matthew P. Stokes, Endre Sebestyén, Matteo Castelli, Luca Torielli, Giorgio Colombo, Mark R. Woodford, Mehdi Mollapour, Dimitra Bourboulia
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112539- (2023)
Summary: c-Src tyrosine kinase is a renowned key intracellular signaling molecule and a potential target for cancer therapy. Secreted c-Src is a recent observation, but how it contributes to extracellular phosphorylation remains elusive. Using a seri
Externí odkaz:
https://doaj.org/article/cd824932e9ec4ba28ad2022efbf0249e
Autor:
Rebecca A. Sager, Farzana Khan, Lorenzo Toneatto, SarahBeth D. Votra, Sarah J. Backe, Mark R. Woodford, Mehdi Mollapour, Dimitra Bourboulia
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The molecular chaperone Heat Shock Protein-90 (Hsp90) is known to interact with over 300 client proteins as well as regulatory factors (eg. nucleotide and proteins) that facilitate execution of its role as a chaperone and, ultimately, client protein
Externí odkaz:
https://doaj.org/article/6e665a91972e47c9bdf7bdf90d269459
Autor:
Sarah J. Backe, Rebecca A. Sager, Katherine A. Meluni, Mark R. Woodford, Dimitra Bourboulia, Mehdi Mollapour
Publikováno v:
Biomolecules, Vol 12, Iss 7, p 928 (2022)
Heat shock protein-90 (Hsp90) is an ATP-dependent molecular chaperone that is tightly regulated by a group of proteins termed co-chaperones. This chaperone system is essential for the stabilization and activation of many key signaling proteins. Recen
Externí odkaz:
https://doaj.org/article/318844d88a05455f8a84a8a3e70f9abe
Publikováno v:
Biomolecules, Vol 12, Iss 6, p 786 (2022)
Mitochondrial function is dependent on molecular chaperones, primarily due to their necessity in the formation of respiratory complexes and clearance of misfolded proteins. Heat shock proteins (Hsps) are a subset of molecular chaperones that function
Externí odkaz:
https://doaj.org/article/5d47277248ea418dae3ad6a40be19fdb
Autor:
Rebecca A. Sager, Mark R. Woodford, Sarah J. Backe, Alan M. Makedon, Alexander J. Baker-Williams, Bryanna T. DiGregorio, David R. Loiselle, Timothy A. Haystead, Natasha E. Zachara, Chrisostomos Prodromou, Dimitra Bourboulia, Laura S. Schmidt, W. Marston Linehan, Gennady Bratslavsky, Mehdi Mollapour
Publikováno v:
Cell Reports, Vol 26, Iss 5, Pp 1344-1356.e5 (2019)
Summary: The molecular chaperone Hsp90 stabilizes and activates client proteins. Co-chaperones and post-translational modifications tightly regulate Hsp90 function and consequently lead to activation of clients. However, it is unclear whether this pr
Externí odkaz:
https://doaj.org/article/de66c6bb8ecb4bfabba4d27f34f19f26
Autor:
Elham Ahanin, Rebecca A. Sager, Sarah J. Backe, Natela Dushukyan, Michael Daneshvar, Gennady Bratslavsky, John Chisholm, Mark R. Woodford, Dimitra Bourboulia, Mehdi Mollapour
Publikováno v:
Journal of Urology. 209
Publikováno v:
Essays in Biochemistry.
Yeast is a valuable model organism for their ease of genetic manipulation, rapid growth rate, and relative similarity to higher eukaryotes. Historically, Saccharomyces cerevisiae has played a major role in discovering the function of complex proteins
Autor:
Rebecca A. Sager, Sarah J. Backe, Diana M. Dunn, Jennifer A. Heritz, Elham Ahanin, Natela Dushukyan, Barry Panaretou, Gennady Bratslavsky, Mark R. Woodford, Dimitra Bourboulia, Mehdi Mollapour
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39be4d747f4c3b9ac7a6aff76a7121c3
https://doi.org/10.2139/ssrn.4352019
https://doi.org/10.2139/ssrn.4352019