Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Sarah J. Aitken"'
Autor:
Siân P. Cartland, Christopher P. Stanley, Christina Bursill, Freda Passam, Gemma A. Figtree, Sanjay Patel, Jacky Loa, Jonathan Golledge, David A. Robinson, Sarah J. Aitken, Mary M. Kavurma
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17439 (2023)
Peripheral artery disease (PAD) is caused by blocked arteries due to atherosclerosis and/or thrombosis which reduce blood flow to the lower limbs. It results in major morbidity, including ischemic limb, claudication, and amputation, with patients als
Externí odkaz:
https://doaj.org/article/d338286688ac4a8dbd885de78c5c9f25
Autor:
Jun Wang, Prasanti Kotagiri, Paul A. Lyons, Rafia S. Al-Lamki, Federica Mescia, Laura Bergamaschi, Lorinda Turner, Michael D. Morgan, Fernando J. Calero-Nieto, Karsten Bach, Nicole Mende, Nicola K. Wilson, Emily R. Watts, Patrick H. Maxwell, Patrick F. Chinnery, Nathalie Kingston, Sofia Papadia, Kathleen E. Stirrups, Neil Walker, Ravindra K. Gupta, David K. Menon, Kieren Allinson, Sarah J. Aitken, Mark Toshner, Michael P. Weekes, James A. Nathan, Sarah R. Walmsley, Willem H. Ouwehand, Mary Kasanicki, Berthold Göttgens, John C. Marioni, Kenneth G.C. Smith, Jordan S. Pober, John R. Bradley
Publikováno v:
iScience, Vol 25, Iss 3, Pp 103971- (2022)
Summary: Clotting Factor V (FV) is primarily synthesized in the liver and when cleaved by thrombin forms pro-coagulant Factor Va (FVa). Using whole blood RNAseq and scRNAseq of peripheral blood mononuclear cells, we find that FV mRNA is expressed in
Externí odkaz:
https://doaj.org/article/6a5d77411f514ca9917df8b819d1dc92
Autor:
Elissavet Kentepozidou, Sarah J. Aitken, Christine Feig, Klara Stefflova, Ximena Ibarra-Soria, Duncan T. Odom, Maša Roller, Paul Flicek
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-19 (2020)
Abstract Background CTCF binding contributes to the establishment of a higher-order genome structure by demarcating the boundaries of large-scale topologically associating domains (TADs). However, despite the importance and conservation of TADs, the
Externí odkaz:
https://doaj.org/article/291fa0f00ad04f14bfde9e67e60009ab
Autor:
Sarah J. Aitken, Ximena Ibarra-Soria, Elissavet Kentepozidou, Paul Flicek, Christine Feig, John C. Marioni, Duncan T. Odom
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-17 (2018)
Abstract Background CTCF binding to DNA helps partition the mammalian genome into discrete structural and regulatory domains. Complete removal of CTCF from mammalian cells causes catastrophic genome dysregulation, likely due to widespread collapse of
Externí odkaz:
https://doaj.org/article/9c93686d4d4a439a9cb8d544dac7a88d
Autor:
Janani Thillainadesan, Helen Box, Leanne Kearney, Vasi Naganathan, Michelle Cunich, Sarah J. Aitken, Sue R. Monaro
Publikováno v:
Australasian Journal on Ageing.
Autor:
Sarah M. Manewell, Sarah J. Aitken, Vanessa L. Nube, Anna M. Crawford, Maria I. Constantino, Stephen M. Twigg, Hylton B. Menz, Catherine Sherrington, Serene S. Paul
Publikováno v:
ANZ journal of surgeryReferences.
There is limited information regarding the number of patients with diabetes-related foot ulceration (DFU) who receive minor or major amputation, and how quickly these amputations occur. This study aimed to identify the incidence of index minor and ma
Autor:
Leanne Kearney, Susan Monaro, Janani Thillainadesan, Alison M. Mudge, Sue Schasser, Robert Tang, Richard Kerdic, Susan J. Li, Vasi Naganathan, Sarah N. Hilmer, Sarah J. Aitken
Publikováno v:
Journal of Surgical Research. 267:91-101
Background Despite the development of geriatrics surgery process quality indicators (QIs), few studies have reported on these QIs in routine surgical practice. Even less is known about the links between these QIs and clinical outcomes, and patient ch
Autor:
Matthew Hoare, Stanley W.K. Ng, Philip Robinson, Natalia Brzozowska, Mathijs A. Sanders, Nicholas Williams, Peter J. Campbell, Efterpi Nikitopoulou, Ming Yang, Natalie Birtchnell, Sarah J. Aitken, Lia Chappell, Foad J. Rouhani, Keiran Raine, Beverley Wilson, Christian Frezza, Inigo Martincorena, Simon F. Brunner, Daniel Leongamornlert, Tim H. H. Coorens, Adam Butler, Tim Butler, Jon W. Teague, Susan E. Davies, Aleksandra Ivovic, Michael R. Stratton, Raheleh Rahbari, Federico Abascal, Huw W. Naylor, Luiza Moore, Yvette Hooks
Publikováno v:
Nature, 598(7881), 473-478. Nature Publishing Group
The progression of chronic liver disease to hepatocellular carcinoma is caused by the acquisition of somatic mutations that affect 20–30 cancer genes1–8. Burdens of somatic mutations are higher and clonal expansions larger in chronic liver diseas
Autor:
Hung-Chang Chen, Nico Mueller, Katherine Stott, Eilidh Rivers, Chrysa Kapeni, Carolin M Sauer, Flavio Beke, Stephen Walsh, Nicola Ashman, Louise O’Brien, Amir Rafati Fard, Arman Godsinia, Fadwa Joud, Olivier Giger, Inti Zlobec, Ioana Olan, Sarah J. Aitken, Matthew Hoare, Richard Mair, Eva Serrao, James D Brenton, Alicia Garcia-Gimenez, Simon E. Richardson, Brian Huntly, David R. Spring, Mikkel-Ole Skjødt, Karsten Skjødt, Marc de la Roche, Maike de la Roche
Leucine-rich repeat-containing G-protein receptor 5 (LGR5) has been characterised as a stem cell and cancer stem cell marker. Previous analyses of LGR5 transcript levels indicate high level expression discriminates malignancies such as colorectal can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b063d90b569482f715ab1d8ee2f0ad58
https://doi.org/10.1101/2022.09.01.506182
https://doi.org/10.1101/2022.09.01.506182
Autor:
Sarah M Manewell, Sarah J Aitken, Vanessa L Nube, Anna M Crawford, Maria I Constantino, Stephen M Twigg, Hylton B Menz, Cathie Sherrington, Serene S Paul
Publikováno v:
Wound Practice and Research. 30