Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Sarah J. Aitken"'
Autor:
Elissavet Kentepozidou, Sarah J. Aitken, Christine Feig, Klara Stefflova, Ximena Ibarra-Soria, Duncan T. Odom, Maša Roller, Paul Flicek
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-19 (2020)
Abstract Background CTCF binding contributes to the establishment of a higher-order genome structure by demarcating the boundaries of large-scale topologically associating domains (TADs). However, despite the importance and conservation of TADs, the
Externí odkaz:
https://doaj.org/article/291fa0f00ad04f14bfde9e67e60009ab
Autor:
Jun Wang, Prasanti Kotagiri, Paul A. Lyons, Rafia S. Al-Lamki, Federica Mescia, Laura Bergamaschi, Lorinda Turner, Michael D. Morgan, Fernando J. Calero-Nieto, Karsten Bach, Nicole Mende, Nicola K. Wilson, Emily R. Watts, Patrick H. Maxwell, Patrick F. Chinnery, Nathalie Kingston, Sofia Papadia, Kathleen E. Stirrups, Neil Walker, Ravindra K. Gupta, David K. Menon, Kieren Allinson, Sarah J. Aitken, Mark Toshner, Michael P. Weekes, James A. Nathan, Sarah R. Walmsley, Willem H. Ouwehand, Mary Kasanicki, Berthold Göttgens, John C. Marioni, Kenneth G.C. Smith, Jordan S. Pober, John R. Bradley
Publikováno v:
iScience, Vol 25, Iss 3, Pp 103971- (2022)
Summary: Clotting Factor V (FV) is primarily synthesized in the liver and when cleaved by thrombin forms pro-coagulant Factor Va (FVa). Using whole blood RNAseq and scRNAseq of peripheral blood mononuclear cells, we find that FV mRNA is expressed in
Externí odkaz:
https://doaj.org/article/6a5d77411f514ca9917df8b819d1dc92
Autor:
Sarah J. Aitken, Ximena Ibarra-Soria, Elissavet Kentepozidou, Paul Flicek, Christine Feig, John C. Marioni, Duncan T. Odom
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-17 (2018)
Abstract Background CTCF binding to DNA helps partition the mammalian genome into discrete structural and regulatory domains. Complete removal of CTCF from mammalian cells causes catastrophic genome dysregulation, likely due to widespread collapse of
Externí odkaz:
https://doaj.org/article/9c93686d4d4a439a9cb8d544dac7a88d
Autor:
Hung-Chang Chen, Nico Mueller, Katherine Stott, Chrysa Kapeni, Eilidh Rivers, Carolin M Sauer, Flavio Beke, Stephen J Walsh, Nicola Ashman, Louise O’Brien, Amir Rafati Fard, Arman Ghodsinia, Changtai Li, Fadwa Joud, Olivier Giger, Inti Zlobec, Ioana Olan, Sarah J Aitken, Matthew Hoare, Richard Mair, Eva Serrao, James D Brenton, Alicia Garcia-Gimenez, Simon E Richardson, Brian Huntly, David R Spring, Mikkel-Ole Skjoedt, Karsten Skjødt, Marc de la Roche, Maike de la Roche
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 9, Pp 2233-2261 (2024)
Abstract We have developed and validated a highly specific, versatile antibody to the extracellular domain of human LGR5 (α-LGR5). α-LGR5 detects LGR5 overexpression in >90% of colorectal cancer (CRC), hepatocellular carcinoma (HCC) and pre-B-ALL t
Externí odkaz:
https://doaj.org/article/4df981d9b6cb481e9115536caaf2c410
Autor:
Hung-Chang Chen, Nico Mueller, Katherine Stott, Chrysa Kapeni, Eilidh Rivers, Carolin M Sauer, Flavio Beke, Stephen J Walsh, Nicola Ashman, Louise O’Brien, Amir Rafati Fard, Arman Ghodsinia, Changtai Li, Fadwa Joud, Olivier Giger, Inti Zlobec, Ioana Olan, Sarah J Aitken, Matthew Hoare, Richard Mair, Eva Serrao, James D Brenton, Alicia Garcia-Gimenez, Simon E Richardson, Brian Huntly, David R Spring, Mikkel-Ole Skjoedt, Karsten Skjødt, Marc de la Roche, Maike de la Roche
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 11, Pp 3026-3026 (2024)
Externí odkaz:
https://doaj.org/article/de85458260f0462188f26c6b70c4d232
Autor:
Jack Wei Chieh Tan, Derek P Chew, David Brieger, John Eikelboom, Gilles Montalescot, Junya Ako, Byeong-Keuk Kim, David KL Quek, Sarah J Aitken, Clara K Chow, Sok Chour, Hung Fat Tse, Upendra Kaul, Isman Firdaus, Takashi Kubo, Boon Wah Liew, Tze Tec Chong, Kenny YK Sin, Hung-I Yeh, Wacin Buddhari, Narathip Chunhamaneewat, Faisal Hasan, Keith AA Fox, Quang Ngoc Nguyen, Sidney TH Lo
Publikováno v:
European Cardiology Review, Vol 16, Iss , Pp - (2021)
The unique characteristics of patients with chronic coronary syndrome (CCS) in the Asia-Pacific region, heterogeneous approaches because of differences in accesses and resources and low number of patients from the Asia-Pacific region in pivotal studi
Externí odkaz:
https://doaj.org/article/6e65974c60be45ae9133bd9a4386d9a8
Autor:
Janani Thillainadesan, Helen Box, Leanne Kearney, Vasi Naganathan, Michelle Cunich, Sarah J. Aitken, Sue R. Monaro
Publikováno v:
Australasian Journal on Ageing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5aad2b463c1579d4b6786240db9b1593
https://doi.org/10.1111/ajag.13176
https://doi.org/10.1111/ajag.13176
Autor:
Leanne Kearney, Susan Monaro, Janani Thillainadesan, Alison M. Mudge, Sue Schasser, Robert Tang, Richard Kerdic, Susan J. Li, Vasi Naganathan, Sarah N. Hilmer, Sarah J. Aitken
Publikováno v:
Journal of Surgical Research. 267:91-101
Background Despite the development of geriatrics surgery process quality indicators (QIs), few studies have reported on these QIs in routine surgical practice. Even less is known about the links between these QIs and clinical outcomes, and patient ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464f845ef1f27feb8ef61d8cefe62e53
https://doi.org/10.1016/j.jss.2021.05.003
https://doi.org/10.1016/j.jss.2021.05.003
Autor:
Matthew Hoare, Stanley W.K. Ng, Philip Robinson, Natalia Brzozowska, Mathijs A. Sanders, Nicholas Williams, Peter J. Campbell, Efterpi Nikitopoulou, Ming Yang, Natalie Birtchnell, Sarah J. Aitken, Lia Chappell, Foad J. Rouhani, Keiran Raine, Beverley Wilson, Christian Frezza, Inigo Martincorena, Simon F. Brunner, Daniel Leongamornlert, Tim H. H. Coorens, Adam Butler, Tim Butler, Jon W. Teague, Susan E. Davies, Aleksandra Ivovic, Michael R. Stratton, Raheleh Rahbari, Federico Abascal, Huw W. Naylor, Luiza Moore, Yvette Hooks
Publikováno v:
Nature, 598(7881), 473-478. Nature Publishing Group
The progression of chronic liver disease to hepatocellular carcinoma is caused by the acquisition of somatic mutations that affect 20–30 cancer genes1–8. Burdens of somatic mutations are higher and clonal expansions larger in chronic liver diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e937c4b992c126b666335b63a112a622
https://doi.org/10.1038/s41586-021-03974-6
https://doi.org/10.1038/s41586-021-03974-6
Autor:
Sarah M. Manewell, Sarah J. Aitken, Vanessa L. Nube, Anna M. Crawford, Maria I. Constantino, Stephen M. Twigg, Hylton B. Menz, Catherine Sherrington, Serene S. Paul
Publikováno v:
ANZ journal of surgeryReferences.
There is limited information regarding the number of patients with diabetes-related foot ulceration (DFU) who receive minor or major amputation, and how quickly these amputations occur. This study aimed to identify the incidence of index minor and ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27e7636b735884f5c710b42e49feb35
https://pubmed.ncbi.nlm.nih.gov/36576076
https://pubmed.ncbi.nlm.nih.gov/36576076