Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Sarah J Taylor"'
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 1, Iss 1, Pp 26-52 (2020)
The Fanconi anaemia (FA) pathway is an important mechanism for cellular DNA damage repair, which functions to remove toxic DNA interstrand crosslinks. This is particularly relevant in the context of ovarian and other cancers which rely extensively on
Externí odkaz:
https://doaj.org/article/0ee6932f74224f3fb52ad84bc51ff6d4
Autor:
Sarah J. Taylor, Robert L. Hollis, Charlie Gourley, C. Simon Herrington, Simon P. Langdon, Mark J. Arends
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundDNA damage repair is frequently dysregulated in high grade serous ovarian cancer (HGSOC), which can lead to changes in chemosensitivity and other phenotypic differences in tumours. RFWD3, a key component of multiple DNA repair and maintenan
Externí odkaz:
https://doaj.org/article/0f37cae0814847a1b8d645d8c736be1e
Autor:
Jacob R. Boos, Hanna N. Jandrain, Emi Hagiuda, Alexander T. Taguchi, Kazuya Hasegawa, Bailey L. Fedun, Sarah J. Taylor, Sofhia M. Elad, Sarah E. Faber, Takashi Kumasaka, Toshio Iwasaki, Werner J. Geldenhuys
Publikováno v:
Advances in Redox Research, Vol 6, Iss , Pp 100048- (2022)
CISD-1/mitoNEET is an evolutionarily conserved outer mitochondrial membrane [2Fe-2S] protein that regulates mitochondrial function and morphology. The [2Fe-2S] clusters are redox reactive and shown to mediate oxidative stress in vitro and in vivo. Ho
Externí odkaz:
https://doaj.org/article/63ce18420c8049339dc30f096fa06230
Autor:
Amy Newton, Joanna Hu, Thorsten Rosner, George O. Tora, Yu-Wen Li, Joseph Raybon, Yi Hsiao, Xiaoping Hou, Joanne J. Bronson, Nicholas J. Lodge, John E. Macor, David A. Conlon, Carl D. Davis, Jung-Hui Sun, Michael K. Wong, Kevin W. Gillman, Sarah J. Taylor, Umesh Hanumegowda, Rudolph G. Krause, Huiping Zhang, Hong Huang, Matthew T. Taber, Andrew P. Degnan, Rick L. Pieschl
Publikováno v:
ACS Chemical Neuroscience. 7:1635-1640
Combination studies of neurokinin 1 (NK1) receptor antagonists and serotonin-selective reuptake inhibitors (SSRIs) have shown promise in preclinical models of depression. Such a combination may offer important advantages over the current standard of
Autor:
Sarah J. Taylor-Cavelier, Andrea G. Roberts, Elisa G. Geiss, Valerie J. Micol, Nestor L. Lopez-Duran
Publikováno v:
Neuropsychobiology. 80(4)
Background: Trauma can lead to long-term downregulation of the hypothalamic pituitary adrenal (HPA) axis. However, dehydroepiandrosterone (DHEA) has neuroprotective effects that may reduce the need for downregulation of the axis in response to stress
Autor:
Sarah J. Taylor
Publikováno v:
Integrated Impact Assessment ISBN: 9780429045196
Integrated Impact Assessment
Integrated Impact Assessment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b395f2e1f3241b5ed0b7991245953a63
https://doi.org/10.4324/9780429045196-8
https://doi.org/10.4324/9780429045196-8
Autor:
Sarah J. Taylor-Cavelier, Elisa G. Geiss, Valerie J. Micol, Andrea G. Roberts, Nestor L. Lopez-Duran
Publikováno v:
Psychoneuroendocrinology. 110:104424
Background One proposed mechanism for familial transmission of depression risk is impaired ability to regulate stress. While much of this work has focused on the stress hormone cortisol, there is evidence that the neuroprotective hormone dehydroepian
Publikováno v:
International Journal of Exercise Science
Acclimatization to altitude has been shown to improve elements of performance. Use of simulated altitude is popular among athletes across the sports spectrum. This work was on a handheld, re-breathing device touted to enhance performance. Seven recre
Publikováno v:
Psychoneuroendocrinology. 100:S61-S62
Autor:
Kelly Krause, Andrew P. Degnan, George O. Tora, Yu-Wen Li, Daniel G. Morgan, Ramkumar Rajamani, Joanna Hu, Ying Han, Rudolph G. Krause, Joanne J. Bronson, Robert L. Bertekap, Sarah J. Taylor, Kevin W. Gillman, Nicholas J. Lodge, Matthew T. Taber, John E. Macor, Gail K. Mattson, Melissa A. Cunningham, Carl D. Davis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:3039-3043
Depression is a serious illness that affects millions of patients. Current treatments are associated with a number of undesirable side effects. Neurokinin 1 receptor (NK1R) antagonists have recently been shown to potentiate the antidepressant effects