Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Sarah J Lessard"'
Autor:
Pattarawan Pattamaprapanont, Eileen M. Cooney, Tara L. MacDonald, Joao A. Paulo, Hui Pan, Jonathan M. Dreyfuss, Sarah J. Lessard
Publikováno v:
Matrix Biology Plus, Vol 23, Iss , Pp 100159- (2024)
Skeletal muscle has a unique ability to remodel in response to stimuli such as contraction and aerobic exercise training. Phenotypic changes in muscle that occur with training such as a switch to a more oxidative fiber type, and increased capillary d
Externí odkaz:
https://doaj.org/article/37f49428b788458294966f8f3bd9d9c4
Autor:
Jamie-Lee M Thompson, Daniel W D West, Thomas M Doering, Boris P Budiono, Sarah J Lessard, Lauren G Koch, Steven L Britton, Nuala M Byrne, Matthew A Brown, Kevin J Ashton, Vernon G Coffey
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0261723 (2022)
Skeletal muscle atrophy is a physiological response to disuse, aging, and disease. We compared changes in muscle mass and the transcriptome profile after short-term immobilization in a divergent model of high and low responders to endurance training
Externí odkaz:
https://doaj.org/article/5f7d11bb94e3436bace2a33a0215c8a7
Autor:
André L. Queiroz, Sarah J. Lessard, Amanda T. Ouchida, Hygor N. Araujo, Dawit A. Gonçalves, Dimitrius Santiago P. Simões Fróes Guimarães, Bruno G. Teodoro, Kawai So, Enilza M. Espreafico, Michael F. Hirshman, Luciane C. Alberici, Isis do Carmo Kettelhut, Laurie J. Goodyear, Leonardo R. Silveira
Publikováno v:
Molecular Metabolism, Vol 51, Iss , Pp 101226- (2021)
Objective: MicroRNAs (miRNA) are known to regulate the expression of genes involved in several physiological processes including metabolism, mitochondrial biogenesis, proliferation, differentiation, and cell death. Methods: Using “in silico” anal
Externí odkaz:
https://doaj.org/article/f16977abeca54a81845fd637f904eadd
Autor:
Sarah J. Lessard, Tara L. MacDonald, Prerana Pathak, Myoung Sook Han, Vernon G. Coffey, Johann Edge, Donato A. Rivas, Michael F. Hirshman, Roger J. Davis, Laurie J. Goodyear
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Endurance and resistance exercise have different effects on skeletal muscle phenotype. Using mouse models and human subjects, the authors show that JNK/Smad2 signaling acts as molecular switch that when activated by resistance exercise leads to hyper
Externí odkaz:
https://doaj.org/article/9957b067f3d0442eac6cc8a71ac69c2e
Autor:
Tara L. MacDonald, Pattarawan Pattamaprapanont, Eileen M. Cooney, Roberto C. Nava, Joanna Mitri, Samar Hafida, Sarah J. Lessard
Publikováno v:
Diabetes. 71:881-893
Chronic hyperglycemia is associated with low response to aerobic exercise training in rodent models and humans, including reduced aerobic exercise capacity and impaired oxidative remodeling in skeletal muscle. Here, we investigated whether glucose lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e7fe8d7d546c0135e1be46822daada
https://doi.org/10.2337/db21-0934
https://doi.org/10.2337/db21-0934
Publikováno v:
Diabetes. 71
Evidence suggests that hyperglycemia can blunt improvements in aerobic capacity (VO2peak) with exercise training. Accordingly, people with diabetes have lower VO2peak than normoglycemic controls, increasing their risk of complications and mortality.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce76d4e48899677e78ff5832f420c09e
https://doi.org/10.2337/db22-533-p
https://doi.org/10.2337/db22-533-p
Autor:
Prerana Pathak, Steven L. Britton, Pattarawan Pattamaprapanont, Natalie M. Fernandez, Ellen Cristini de Freitas, Joanna Mitri, Tara MacDonald, Sarah J. Lessard, Samar Hafida, Lauren G. Koch
Publikováno v:
Nature Metabolism. 2:902-917
Increased aerobic exercise capacity, as a result of exercise training, has important health benefits. However, some individuals are resistant to improvements in exercise capacity, probably due to undetermined genetic and environmental factors. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87ee24083baeedbe742a2fe0dd4e4e61
https://doi.org/10.1038/s42255-020-0240-7
https://doi.org/10.1038/s42255-020-0240-7
Autor:
Renee Wurth, Tara MacDonald, Jonathan Scheiman, Clary B. Clish, Jacob M. Luber, Julian Avila-Pacheco, Loc-Duyen D. Pham, Theodore A. Chavkin, Angela Tung, Sarah J. Lessard, George M. Church, Zhen Yang, Aleksandar Kostic, Marsha C. Wibowo, Mohammad W. Hattab, Sukanya Punthambaker, Braden T. Tierney
Publikováno v:
Nature medicine
The human gut microbiome is linked to many states of human health and disease1. The metabolic repertoire of the gut microbiome is vast, but the health implications of these bacterial pathways are poorly understood. In this study, we identify a link b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca7dbdf12f7ffd7e0aa653b770d8b381
https://doi.org/10.1038/s41591-019-0485-4
https://doi.org/10.1038/s41591-019-0485-4
Autor:
Kıvanç Birsoy, Sarah J. Lessard
Publikováno v:
Nature metabolism. 3(7)
In this instalment of Career pathways, Kivanc Birsoy and Sarah Lessard recount their roads to scientific research and reflect on how each step in their training prepared them for life as a group leader.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc58a2491177b03fb7188a01fea658ae
https://pubmed.ncbi.nlm.nih.gov/34099927
https://pubmed.ncbi.nlm.nih.gov/34099927
Publikováno v:
Diabetes. 70
In rodent models and humans, hyperglycemia is associated with an impaired adaptive response to aerobic exercise, which includes blunted improvements in aerobic capacity and impaired aerobic remodeling of skeletal muscle. To test whether glucose lower
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::977dc7bd579eab6d2d6248671dedf134
https://doi.org/10.2337/db21-494-p
https://doi.org/10.2337/db21-494-p