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pro vyhledávání: '"Sarah J Heighton"'
Autor:
Qian Zhang, Kedar S. Vaidya, Christine M Grinnell, Mark G. Anderson, Anatol Oleksijew, Sasmita Mishra, Lora A. Tucker, Jieyi Wang, Joann P. Palma, William N. Pappano, Erwin R. Boghaert, Sarah J Heighton, Michael J. Mitten, Edward B. Reilly
Publikováno v:
Pharmacology. 100:229-242
ABT-700 is a therapeutic antibody against the hepatocyte growth factor receptor (MET). At doses or regimens that lead to exposures exceeding optimum in vivo, the efficacy of ABT-700 is unexpectedly reduced. We hypothesized that this reduction in effi