Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Sarah J Freemantle"'
Autor:
Doha Shokry, Mehwish W. Khan, Christine Powell, Samantha Johnson, Brayden C. Rennels, Raya I. Boyd, Zhengyang Sun, Zeeshan Fazal, Sarah J. Freemantle, Maryanna H. Parker, Miranda D. Vieson, Jonathan P. Samuelson, Michael J. Spinella, Ratnakar Singh
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Testicular germ cell tumors (TGCTs) can be treated with cisplatin-based therapy. However, a clinically significant number of cisplatin-resistant patients die from progressive disease as no effective alternatives exist. Curative cisplatin the
Externí odkaz:
https://doaj.org/article/68755ecf9402453293b42c650e2ab10c
Autor:
Kelly C Heim, Joshua J Gamsby, Mary P Hever, Sarah J Freemantle, Jennifer J Loros, Jay C Dunlap, Michael J Spinella
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7639 (2009)
Mechanisms that underlie oscillatory transcriptional activity of nuclear receptors (NRs) are incompletely understood. Evidence exists for rapid, cyclic recruitment of coregulatory complexes upon activation of nuclear receptors. RIP140 is a NR coregul
Externí odkaz:
https://doaj.org/article/2d1f7ad0450446ba93ba15964ad48fed
Autor:
Andrea K. Corbet, Emmanuel Bikorimana, Raya I. Boyd, Doha Shokry, Kelly Kries, Ayush Gupta, Anneliese Paton, Zhengyang Sun, Zeeshan Fazal, Sarah J. Freemantle, Erik R. Nelson, Michael J. Spinella, Ratnakar Singh
Publikováno v:
Translational Oncology, Vol 33, Iss , Pp 101676- (2023)
G0/G1 switch gene 2 (G0S2) is known to inhibit lipolysis by inhibiting adipose triglyceride lipase (ATGL). In this report, we dissect the role of G0S2 in ER+ versus ER- breast cancer. Overexpression of G0S2 in ER- cells increased cell proliferation,
Externí odkaz:
https://doaj.org/article/cbcbc9b7c9dc4ba880141b3cdbbac673
Autor:
Raya I. Boyd, Doha Shokry, Zeeshan Fazal, Brayden C. Rennels, Sarah J. Freemantle, Michael R. La Frano, Gail S. Prins, Zeynep Madak Erdogan, Joseph Irudayaraj, Ratnakar Singh, Michael J. Spinella
Publikováno v:
Toxics, Vol 12, Iss 4, p 232 (2024)
The potential effects of poly- and perfluoroalkyl substances (PFAS) are a recently emergent human and environmental health concern. There is a consistent link between PFAS exposure and cancer, but the mechanisms are poorly understood. Although epidem
Externí odkaz:
https://doaj.org/article/63bec03f1c444472b4882a8ed84927b2
Autor:
Ratnakar Singh, Zeeshan Fazal, Emmanuel Bikorimana, Raya I. Boyd, Cliff Yerby, Megan Tomlin, Hannah Baldwin, Doha Shokry, Andrea K. Corbet, Khadeeja Shahid, Aleyah Hattab, Sarah J. Freemantle, Michael J. Spinella
Publikováno v:
Molecular Oncology, Vol 16, Iss 3, Pp 683-698 (2022)
Testicular germ cell tumors (TGCTs) are aggressive but sensitive to cisplatin‐based chemotherapy. Alternative therapies are needed for tumors refractory to cisplatin with hypomethylating agents providing one possibility. The mechanisms of cisplatin
Externí odkaz:
https://doaj.org/article/1996a69b2850475d84e180ad54ed68ef
Autor:
Zeeshan Fazal, Ratnakar Singh, Fang Fang, Emmanuel Bikorimana, Hannah Baldwin, Andrea Corbet, Megan Tomlin, Cliff Yerby, Nabil Adra, Costantine Albany, Sarah Lee, Sarah J. Freemantle, Kenneth P Nephew, Brock C Christensen, Michael J. Spinella
Publikováno v:
Epigenetics, Vol 16, Iss 10, Pp 1071-1084 (2021)
Testicular germ cell tumours (TGCTs) respond well to cisplatin-based therapy. However, cisplatin resistance and poor outcomes do occur. It has been suggested that a shift towards DNA hypermethylation mediates cisplatin resistance in TGCT cells, altho
Externí odkaz:
https://doaj.org/article/4b7b7223caa54e218dd20f2ec7342e9a
Autor:
Ethan Dmitrovsky, Sarah J. Freemantle, Duane A. Compton, Faye M. Johnson, Masanori Kawakami, Xi Liu, David Sekula, Lisa Maria Mustachio, Kristina Godek, Bernardo Orr, Shanhu Hu, Alexey V. Danilov
Despite advances in targeted therapy, lung cancer remains the most common cause of cancer-related mortality in the United States. Chromosomal instability is a prominent feature in lung cancer and, because it rarely occurs in normal cells, it represen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74fbb1680fe603f0fbb03a3c416c60d0
https://doi.org/10.1158/1535-7163.c.6538363
https://doi.org/10.1158/1535-7163.c.6538363
Autor:
Ethan Dmitrovsky, Sarah J. Freemantle, Xi Liu, Shanhu Hu, Fadzai Chinyengetere, John F. Hancock, Kwang-jin Cho, Masanori Kawakami, Jason Roszik, Samir M. Hanash, Hiroyuki Katayama, Ignacio Wistuba, Pamela Andrea Villalobos, Barbara Mino, Jaime Rodriguez-Canales, Vincent Memoli, Laura J. Tafe, Yun Lu, Lisa Maria Mustachio
KRAS is frequently mutated in lung cancers and is associated with aggressive biology and chemotherapy resistance. Therefore, innovative approaches are needed to treat these lung cancers. Prior work implicated the IFN-stimulated gene 15 (ISG15) deubiq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd5c9584958b0a004b044ec7e99060a1
https://doi.org/10.1158/1541-7786.c.6539967.v1
https://doi.org/10.1158/1541-7786.c.6539967.v1
Autor:
Ethan Dmitrovsky, Sarah J. Freemantle, Duane A. Compton, Faye M. Johnson, Masanori Kawakami, Xi Liu, David Sekula, Lisa Maria Mustachio, Kristina Godek, Bernardo Orr, Shanhu Hu, Alexey V. Danilov
Movie video files of a) H1299 and b) HOP62 cells were treated with 25 or 50 nM dinaciclib and continuously imaged as described in the Methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9069a8a0528305d25c2d498b03683e42
https://doi.org/10.1158/1535-7163.22506325.v1
https://doi.org/10.1158/1535-7163.22506325.v1
Autor:
Ethan Dmitrovsky, Vincent Memoli, Angeline S. Andrew, Sarah J. Freemantle, David Sekula, Qing Feng, Tian Ma, Fabrizio Galimberti, Yun Lu, Alexandra Lopez-Aguiar, Andrey V. Dolinko, Fadzai Chinyengetere, Yongli Guo
PDF file, 88K, Model of UBP43 action in tumors and how inhibition of UBP43 activity represents a new therapeutic target.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce136b47b62fdfc1cd08725e4a6964c
https://doi.org/10.1158/1535-7163.22498656.v1
https://doi.org/10.1158/1535-7163.22498656.v1