Výsledky vyhledávání - "Sarah J Crowell"

Application of blood microsampling in cynomolgus monkey and demonstration of equivalent monoclonal antibody PK parameters compared to conventional sampling

Autor: Dean Messing, Lisa Dyleski, Sarah J Crowell, Boris Gorovits, Zhiping You, Sarah Murphy, Alison Joyce, Meghan Gomes, Jennifer Cargill, Ying Wang

Publikováno v: Pharmaceutical research. 38(5)

The purpose of this study was to evaluate the suitability of whole blood microsampling procedures in non-human primate (NHP) to support toxicokinetic assessments of biotherapeutics in non-human primates. A one-month single dose intravenous pharmacoki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4d6b8d1309c7f698770e87361ec761
https://pubmed.ncbi.nlm.nih.gov/33982224

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Application of emerging biomarkers of acute kidney injury in development of kidney-sparing polypeptide-based antibiotics

Autor: Sarah J Crowell, Magee Thomas Victor, Jiri Aubrecht, Deborah A. Burt, David C. Ackley

Publikováno v: Drug and chemical toxicology. 37(2)

Polypeptide antibiotics, such as polymyxins and aminoglycosides, are essential for treatment of life-threatening Gram-negative infections. Acute kidney injury (AKI) attributed to treatment with these agents severely limits their clinical application.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a63189d6677f4017eacd1b4d87c31dfc
https://pubmed.ncbi.nlm.nih.gov/24128070

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