Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Sarah J Aitken"'
Autor:
Hung-Chang Chen, Nico Mueller, Katherine Stott, Chrysa Kapeni, Eilidh Rivers, Carolin M Sauer, Flavio Beke, Stephen J Walsh, Nicola Ashman, Louise O’Brien, Amir Rafati Fard, Arman Ghodsinia, Changtai Li, Fadwa Joud, Olivier Giger, Inti Zlobec, Ioana Olan, Sarah J Aitken, Matthew Hoare, Richard Mair, Eva Serrao, James D Brenton, Alicia Garcia-Gimenez, Simon E Richardson, Brian Huntly, David R Spring, Mikkel-Ole Skjoedt, Karsten Skjødt, Marc de la Roche, Maike de la Roche
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 9, Pp 2233-2261 (2024)
Abstract We have developed and validated a highly specific, versatile antibody to the extracellular domain of human LGR5 (α-LGR5). α-LGR5 detects LGR5 overexpression in >90% of colorectal cancer (CRC), hepatocellular carcinoma (HCC) and pre-B-ALL t
Externí odkaz:
https://doaj.org/article/4df981d9b6cb481e9115536caaf2c410
Autor:
Jack Wei Chieh Tan, Derek P Chew, David Brieger, John Eikelboom, Gilles Montalescot, Junya Ako, Byeong-Keuk Kim, David KL Quek, Sarah J Aitken, Clara K Chow, Sok Chour, Hung Fat Tse, Upendra Kaul, Isman Firdaus, Takashi Kubo, Boon Wah Liew, Tze Tec Chong, Kenny YK Sin, Hung-I Yeh, Wacin Buddhari, Narathip Chunhamaneewat, Faisal Hasan, Keith AA Fox, Quang Ngoc Nguyen, Sidney TH Lo
Publikováno v:
European Cardiology Review, Vol 16, Iss , Pp - (2021)
The unique characteristics of patients with chronic coronary syndrome (CCS) in the Asia-Pacific region, heterogeneous approaches because of differences in accesses and resources and low number of patients from the Asia-Pacific region in pivotal studi
Externí odkaz:
https://doaj.org/article/6e65974c60be45ae9133bd9a4386d9a8
Autor:
Christina Ernst, Jeremy Pike, Sarah J Aitken, Hannah K Long, Nils Eling, Lovorka Stojic, Michelle C Ward, Frances Connor, Timothy F Rayner, Margus Lukk, Robert J Klose, Claudia Kutter, Duncan T Odom
Publikováno v:
eLife, Vol 5 (2016)
Most human aneuploidies originate maternally, due in part to the presence of highly stringent checkpoints during male meiosis. Indeed, male sterility is common among aneuploid mice used to study chromosomal abnormalities, and male germline transmissi
Externí odkaz:
https://doaj.org/article/1f142675989441129d0e1c5ce8d2c48e
Autor:
Jun Wang, Prasanti Kotagiri, Paul A. Lyons, Rafia S. Al-Lamki, Federica Mescia, Laura Bergamaschi, Lorinda Turner, Michael D. Morgan, Fernando J. Calero-Nieto, Karsten Bach, Nicole Mende, Nicola K. Wilson, Emily R. Watts, Patrick H. Maxwell, Patrick F. Chinnery, Nathalie Kingston, Sofia Papadia, Kathleen E. Stirrups, Neil Walker, Ravindra K. Gupta, David K. Menon, Kieren Allinson, Sarah J. Aitken, Mark Toshner, Michael P. Weekes, James A. Nathan, Sarah R. Walmsley, Willem H. Ouwehand, Mary Kasanicki, Berthold Göttgens, John C. Marioni, Kenneth G.C. Smith, Jordan S. Pober, John R. Bradley
Publikováno v:
iScience, Vol 25, Iss 3, Pp 103971- (2022)
Summary: Clotting Factor V (FV) is primarily synthesized in the liver and when cleaved by thrombin forms pro-coagulant Factor Va (FVa). Using whole blood RNAseq and scRNAseq of peripheral blood mononuclear cells, we find that FV mRNA is expressed in
Externí odkaz:
https://doaj.org/article/6a5d77411f514ca9917df8b819d1dc92
Autor:
Elissavet Kentepozidou, Sarah J. Aitken, Christine Feig, Klara Stefflova, Ximena Ibarra-Soria, Duncan T. Odom, Maša Roller, Paul Flicek
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-19 (2020)
Abstract Background CTCF binding contributes to the establishment of a higher-order genome structure by demarcating the boundaries of large-scale topologically associating domains (TADs). However, despite the importance and conservation of TADs, the
Externí odkaz:
https://doaj.org/article/291fa0f00ad04f14bfde9e67e60009ab
Autor:
Janani Thillainadesan, Helen Box, Leanne Kearney, Vasi Naganathan, Michelle Cunich, Sarah J. Aitken, Sue R. Monaro
Publikováno v:
Australasian Journal on Ageing.
Autor:
Leanne Kearney, Susan Monaro, Janani Thillainadesan, Alison M. Mudge, Sue Schasser, Robert Tang, Richard Kerdic, Susan J. Li, Vasi Naganathan, Sarah N. Hilmer, Sarah J. Aitken
Publikováno v:
Journal of Surgical Research. 267:91-101
Background Despite the development of geriatrics surgery process quality indicators (QIs), few studies have reported on these QIs in routine surgical practice. Even less is known about the links between these QIs and clinical outcomes, and patient ch
Autor:
Sarah M. Manewell, Sarah J. Aitken, Vanessa L. Nube, Anna M. Crawford, Maria I. Constantino, Stephen M. Twigg, Hylton B. Menz, Catherine Sherrington, Serene S. Paul
Publikováno v:
ANZ journal of surgeryReferences.
There is limited information regarding the number of patients with diabetes-related foot ulceration (DFU) who receive minor or major amputation, and how quickly these amputations occur. This study aimed to identify the incidence of index minor and ma
Autor:
Matthew Hoare, Stanley W.K. Ng, Philip Robinson, Natalia Brzozowska, Mathijs A. Sanders, Nicholas Williams, Peter J. Campbell, Efterpi Nikitopoulou, Ming Yang, Natalie Birtchnell, Sarah J. Aitken, Lia Chappell, Foad J. Rouhani, Keiran Raine, Beverley Wilson, Christian Frezza, Inigo Martincorena, Simon F. Brunner, Daniel Leongamornlert, Tim H. H. Coorens, Adam Butler, Tim Butler, Jon W. Teague, Susan E. Davies, Aleksandra Ivovic, Michael R. Stratton, Raheleh Rahbari, Federico Abascal, Huw W. Naylor, Luiza Moore, Yvette Hooks
Publikováno v:
Nature, 598(7881), 473-478. Nature Publishing Group
The progression of chronic liver disease to hepatocellular carcinoma is caused by the acquisition of somatic mutations that affect 20–30 cancer genes1–8. Burdens of somatic mutations are higher and clonal expansions larger in chronic liver diseas
Autor:
Hung-Chang Chen, Nico Mueller, Katherine Stott, Eilidh Rivers, Chrysa Kapeni, Carolin M Sauer, Flavio Beke, Stephen Walsh, Nicola Ashman, Louise O’Brien, Amir Rafati Fard, Arman Godsinia, Fadwa Joud, Olivier Giger, Inti Zlobec, Ioana Olan, Sarah J. Aitken, Matthew Hoare, Richard Mair, Eva Serrao, James D Brenton, Alicia Garcia-Gimenez, Simon E. Richardson, Brian Huntly, David R. Spring, Mikkel-Ole Skjødt, Karsten Skjødt, Marc de la Roche, Maike de la Roche
Leucine-rich repeat-containing G-protein receptor 5 (LGR5) has been characterised as a stem cell and cancer stem cell marker. Previous analyses of LGR5 transcript levels indicate high level expression discriminates malignancies such as colorectal can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b063d90b569482f715ab1d8ee2f0ad58
https://doi.org/10.1101/2022.09.01.506182
https://doi.org/10.1101/2022.09.01.506182