Zobrazeno 1 - 10
of 498
pro vyhledávání: '"Sarah J, Tabrizi"'
Autor:
Mohsen Ghofrani-Jahromi, Govinda R. Poudel, Adeel Razi, Pubu M. Abeyasinghe, Jane S. Paulsen, Sarah J. Tabrizi, Susmita Saha, Nellie Georgiou-Karistianis
Publikováno v:
NeuroImage: Clinical, Vol 43, Iss , Pp 103650- (2024)
Background: In Huntington’s disease clinical trials, recruitment and stratification approaches primarily rely on genetic load, cognitive and motor assessment scores. They focus less on in vivo brain imaging markers, which reflect neuropathology wel
Externí odkaz:
https://doaj.org/article/c5bd680ba33d418db012ceb4407de126
Autor:
Andreas Neueder, Philipp Nitzschner, Ronja Wagner, Julia Hummel, Franziska Hoschek, Maximilian Wagner, Alshaimaa Abdelmoez, Björn vonEinem, G. Bernhard Landwehrmeyer, Sarah J. Tabrizi, Michael Orth
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 1, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/19f6feb2cffc4452b1934535095a3080
Autor:
Igor Koval, Thomas Dighiero-Brecht, Allan J. Tobin, Sarah J. Tabrizi, Rachael I. Scahill, Sophie Tezenas du Montcel, Stanley Durrleman, Alexandra Durr
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Variability in neurodegenerative disease progression poses great challenges for the evaluation of potential treatments. Identifying the persons who will experience significant progression in the short term is key for the implementation of tr
Externí odkaz:
https://doaj.org/article/2bff017528f8454fab145b9780be3066
Autor:
Yara Refaat Hassan, Filipe Brogueira Rodrigues, Paul Zeun, Lauren M. Byrne, Carlos Estevez-Fraga, Rosanna Tortelli, Rachael I. Scahill, Edward J. Wild, Sarah J. Tabrizi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Lumbar puncture (LP) has become increasingly common for people with Huntington’s disease (HD) both to administer intrathecal investigational medicinal products and to collect cerebrospinal fluid to develop biological markers to track disea
Externí odkaz:
https://doaj.org/article/ad4a5e730417443781456cf2e0327ad6
Autor:
Andreas Neueder, Kerstin Kojer, Tanja Hering, Daniel J. Lavery, Jian Chen, Nathalie Birth, Jaqueline Hallitsch, Sonja Trautmann, Jennifer Parker, Michael Flower, Huma Sethi, Salman Haider, Jong-Min Lee, Sarah J. Tabrizi, Michael Orth
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-21 (2022)
Abstract Background A major challenge in neurodegenerative diseases concerns identifying biological disease signatures that track with disease progression or respond to an intervention. Several clinical trials in Huntington disease (HD), an inherited
Externí odkaz:
https://doaj.org/article/91d57965d1a84fddb14c7d745fbb7ca5
Progressive alterations in white matter microstructure across the timecourse of Huntington's disease
Autor:
Carlos Estevez‐Fraga, Michael S. Elmalem, Marina Papoutsi, Alexandra Durr, Elin M. Rees, Nicola Z. Hobbs, Raymund A. C. Roos, Bernhard Landwehrmeyer, Blair R. Leavitt, Douglas R. Langbehn, Rachael I. Scahill, Geraint Rees, Sarah J. Tabrizi, Sarah Gregory
Publikováno v:
Brain and Behavior, Vol 13, Iss 4, Pp n/a-n/a (2023)
Abstract Background Whole‐brain longitudinal diffusion studies are crucial to examine changes in structural connectivity in neurodegeneration. Here, we investigated the longitudinal alterations in white matter (WM) microstructure across the timecou
Externí odkaz:
https://doaj.org/article/14760f7b295f464cbc8b231b3d170168
Autor:
Grace C. O’Regan, Sahar H. Farag, Caroline S. Casey, Alison Wood-Kaczmar, Jennifer M. Pocock, Sarah J. Tabrizi, Ralph Andre
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-17 (2021)
Abstract Background Neuroinflammation may contribute to the pathogenesis of Huntington’s disease, given evidence of activated microglia and elevated levels of inflammatory molecules in disease gene carriers, even those many years from symptom onset
Externí odkaz:
https://doaj.org/article/e73b03f2b0fe4371bf25bcd8a40ef24b
Autor:
Paul Zeun, Peter McColgan, Thijs Dhollander, Sarah Gregory, Eileanoir B. Johnson, Marina Papoutsi, Akshay Nair, Rachael I. Scahill, Geraint Rees, Sarah J. Tabrizi
Publikováno v:
NeuroImage: Clinical, Vol 33, Iss , Pp 102927- (2022)
Objectives: To investigate the timeframe prior to symptom onset when cortico-basal ganglia white matter (white matter) loss begins in premanifest Huntington’s disease (preHD), and which striatal and thalamic sub-region white matter tracts are most
Externí odkaz:
https://doaj.org/article/fd0c448432f7454cb40720aa895efbbd
Autor:
Jenny Lange, Alison Wood-Kaczmar, Aneesa Ali, Sahar Farag, Rhia Ghosh, Jennifer Parker, Caroline Casey, Yumiko Uno, Akiyoshi Kunugi, Patrizia Ferretti, Ralph Andre, Sarah J. Tabrizi
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin gene (HTT). Disease progression is characterized by the loss of vulnerable neuronal populations within the striatum. A consisten
Externí odkaz:
https://doaj.org/article/b010990ba23c484fa23d6876c8a16e4d
Autor:
Peter A. Wijeratne, Eileanoir B. Johnson, Sarah Gregory, Nellie Georgiou-Karistianis, Jane S. Paulsen, Rachael I. Scahill, Sarah J. Tabrizi, Daniel C. Alexander
Publikováno v:
Frontiers in Big Data, Vol 4 (2021)
Understanding the order and progression of change in biomarkers of neurodegeneration is essential to detect the effects of pharmacological interventions on these biomarkers. In Huntington’s disease (HD), motor, cognitive and MRI biomarkers are curr
Externí odkaz:
https://doaj.org/article/478832a5997e44388211a35b3a889871