Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Sarah J, Marzi"'
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract Sporadic Parkinson’s disease (PD) is a progressive neurodegenerative disease, with a complex risk structure thought to be influenced by interactions between genetic variants and environmental exposures, although the full aetiology is unkno
Externí odkaz:
https://doaj.org/article/84b459a245a440f0b110f936b50995ea
Autor:
Francisco Rodriguez-Algarra, Robert A. E. Seaborne, Amy F. Danson, Selin Yildizoglu, Harunori Yoshikawa, Pui Pik Law, Zakaryya Ahmad, Victoria A. Maudsley, Ama Brew, Nadine Holmes, Mateus Ochôa, Alan Hodgkinson, Sarah J. Marzi, Madapura M. Pradeepa, Matthew Loose, Michelle L. Holland, Vardhman K. Rakyan
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-17 (2022)
Abstract Background Ribosomal DNA (rDNA) displays substantial inter-individual genetic variation in human and mouse. A systematic analysis of how this variation impacts epigenetic states and expression of the rDNA has thus far not been performed. Res
Externí odkaz:
https://doaj.org/article/23885abfca144e819fd856b19d936cdb
Autor:
Andrea Cerase, Alexander N. Young, Nerea Blanes Ruiz, Andreas Buness, Gabrielle M. Sant, Mirjam Arnold, Monica Di Giacomo, Michela Ascolani, Manish Kumar, Andreas Hierholzer, Giuseppe Trigiante, Sarah J. Marzi, Philip Avner
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Andrea Cerase et al. report that the chromatin remodeler Chd8 is a key regulator of mammalian Xist expression and therefore X chromosome inactivation. They find that Chd8 activates Xist expression in embryonic stem cells, while in differentiating cel
Externí odkaz:
https://doaj.org/article/d26e720a693341bcb6cd62cfbe1b421b
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-6 (2019)
Abstract Most variants associated with complex phenotypes in genome-wide association studies (GWAS) do not directly index coding changes affecting protein structure. Instead they are hypothesized to influence gene regulation, with common variants ass
Externí odkaz:
https://doaj.org/article/9768d01ecf1940838a4dc0c315beb225
Autor:
Adam R Smith, Rebecca G Smith, Ruby Macdonald, Sarah J Marzi, Joe Burrage, Claire Troakes, Safa Al-Sarraj, Jonathan Mill, Katie Lunnon
Publikováno v:
Future Science OA, Vol 7, Iss 4 (2021)
Several epigenome-wide association studies of DNA methylation have highlighted altered DNA methylation in the ANK1 gene in Alzheimer's disease (AD) brain samples. However, no study has specifically examined ANK1 histone modifications in the disease.
Externí odkaz:
https://doaj.org/article/e8edfd606bbb46548e6a839ae3c45883
Autor:
Fredrika Åsenius, Tyler J Gorrie-Stone, Ama Brew, Yasmin Panchbhaya, Elizabeth Williamson, Leonard C Schalkwyk, Vardhman K Rakyan, Michelle L Holland, Sarah J Marzi, David J Williams
Publikováno v:
PLoS Genetics, Vol 16, Iss 10, p e1009035 (2020)
Epidemiological research suggests that paternal obesity may increase the risk of fathering small for gestational age offspring. Studies in non-human mammals indicate that such associations could be mediated by DNA methylation changes in spermatozoa t
Externí odkaz:
https://doaj.org/article/4e7639db547f4dac8a0fb9dbae7c93a9
Publikováno v:
BMC Biology, Vol 16, Iss 1, Pp 1-10 (2018)
Abstract Background Environmental influences fluctuate throughout the life course of an organism. It is therefore important to understand how the timing of exposure impacts molecular responses. Herein, we examine the responses of two key molecular ma
Externí odkaz:
https://doaj.org/article/8a3af5aa4e4d48f8bf4e940106f00c7e
Autor:
Nadine Holmes, Robert A. Seaborne, Madapura M Pradeepa, Sarah J. Marzi, Francisco Rodríguez-Algarra, Alan Hodgkinson, Amy F. Danson, Matthew Loose, Victoria A Maudsley, Vardhman K. Rakyan, Pui Pik Law, Ama Brew, Zakaryya Ahmad, Harunori Yoshikawa, Michelle L. Holland, Selin Yildizoglu
Publikováno v:
Genome biology. 23(1)
Background Ribosomal DNA (rDNA) displays substantial inter-individual genetic variation in human and mouse. A systematic analysis of how this variation impacts epigenetic states and expression of the rDNA has thus far not been performed. Results Usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0e2e801ce78a277ec30637f1ec41fed
https://pubmed.ncbi.nlm.nih.gov/35164830
https://pubmed.ncbi.nlm.nih.gov/35164830
Chromatin profiling studies have shown the importance of gene regulation in driving heritability and environmental risk of brain disorders. Acetylation of histone H3 lysine 27 (H3K27ac) has emerged as an informative disease-associated epigenetic mark
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2925551939201564e160c890f6dbb2d3
https://doi.org/10.1101/2021.09.06.459142
https://doi.org/10.1101/2021.09.06.459142
Autor:
Nerea Blanes Ruiz, Giuseppe Trigiante, Monica Di Giacomo, Alexander N. Young, Gabrielle M Sant, Sarah J. Marzi, Andrea Cerase, Andreas Buness, Andreas Hierholzer, Philip Avner, Manish Kumar, Michela Ascolani, Mirjam Arnold
Publikováno v:
Communications Biology
Communications Biology, 4 (1)
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Communications Biology, 4 (1)
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Female mammals achieve dosage compensation by inactivating one of their two X chromosomes during development, a process entirely dependent on Xist, an X-linked long non-coding RNA (lncRNA). At the onset of X chromosome inactivation (XCI), Xist is up-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90e3e18625767614e038f16d582be598
http://europepmc.org/articles/PMC8050208
http://europepmc.org/articles/PMC8050208